期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 433, 期 C, 页码 56-65出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2016.05.019
关键词
AMH; FSH; Follicular development; miR-181a; miR-181b
资金
- Foundation for Reproductive Medicine Grant
- CHR
- Eunice Kennedy Shriver NICHD/NIH (NCTRI) [P50-HD28934]
Anti-Mullerian hormone (AMH) is a member of the transforming growth factor-beta superfamily and plays a crucial role in testicular and ovarian functions. In clinical practice, AMH is used as a diagnostic and/or prognostic marker in women in association with ovulation induction and in various pathophysiological conditions. Despite widespread clinical use of AMH, our mechanistic understanding of AMH actions in regulating follicular development is limited. Using a mouse model, we in this study report that in vivo AMH treatment while stalls follicular development and inhibits ovulation, also prevents follicular atresia. We further show that these AMH actions are mediated through induction of two miRNAs, miR-181a and miR-181b, which regulate various aspects of FSH signaling and follicular growth, ultimately affecting downstream gene expression and folliculogenesis. We also report that in this mouse model AMH pretreatment prior to superovulation improves oocyte yield. These studies, therefore, offer new mechanistic insight into AMH actions in folliculogenesis and point toward potential utilization of AMH as a therapeutic agent. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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