期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
卷 443, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2023.114879
关键词
Green synthesis; Fluorescent stain; Bioimaging; Carbon quantum dots
This study presents an economical and ecologically sustainable method for producing biocompatible fluorescent carbon quantum dots (CQDs) from bathua leaf extract. The CQDs have excellent water solubility and robust photo-stability, making them a cost-effective alternative to organic or synthetic fluorescent probes for cellular imaging. The N, K, Ca-doped CQDs also exhibit acceptable cell survival and cytotoxicity, making them suitable for various living organisms.
This study demonstrated an economical, ecologically sustainable, and simple method for producing biocompatible fluorescent carbon quantum dots (CQDs) co-doped with N, K, and Ca from bathua (Chenopodium album), a popular medicinal herb leaf extract and nutritious vegetable. The nearly spherical shaped CQDs were discovered to be 3-5 nm in size in nature, with a quantum yield of around 48.12%, robust photo-stability, and excellent water solubility. Various morphological, compositional, physicochemical and optical characteristics were investigated. Additional factors affecting the photoluminescence of CQDs, such as hydrothermal process parameters, pH, and solvent sensitivity, were investigated further. Moreover, the newly synthesized N, K, Ca-doped CQDs were demonstrated to be a useful fluorescent nanoprobe for in vitro cellular imaging of SH-SY5Y human neuroblastoma cells, as well as other living organisms such as bacteria, fungal, and plant cells, as a cost-effective alternative to organic or synthetic fluorescent probes. Cell survival and cytotoxicity were found to be acceptable, with 95% of SH-SY5Y and HCT-116 cells surviving and other organisms able to withstand higher doses (10.9 mg/ mL) for up to 4 days.
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