A novel pharmaceutical preparation of Tripterygium wilfordii Hook. f. regulates macrophage polarization to alleviate inflammation in rheumatoid arthritis

Summary: Excessive inflammatory reactions cause immune imbalance in sepsis, with macrophages playing a crucial role in regulating the inflammatory response. In this study, upregulation of VEGFA was observed in a mouse model of sepsis, and inhibiting its expression using siRNA technology was found to inhibit M1 polarization and reduce cytokine secretion in macrophages. Further investigation revealed that knocking down VEGFA also inhibited glycolysis in macrophages and alleviated organ damage and pathological conditions in septic mice. These findings suggest that targeting VEGFA could be an important strategy for relieving sepsis.

Summary: The study explored the preventive effect of Euphorbium total triterpenes (TTE) on FCA-induced arthritis in rats and its mechanism. The results showed that TTE possessed anti-arthritis effects, and its mechanism may be related to its anti-inflammatory and immunomodulatory properties, as well as regulation of the PI3K/AKT/Bax and NF-kappa B/NLRP3 signaling pathway.

Summary: The study found that Chinese patients with RA have specific illness perceptions that impact their HRQoL. Personal control and treatment control were positively associated with HRQoL, while identity and emotional response were negatively associated.