期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 425, 期 C, 页码 69-83出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2016.01.014
关键词
Endoglin; Endometrium receptivity; Delayed implantation; Decidualization; Implantation sites; Blastocyst attachment
资金
- Indian Council of Medical Research (ICMR), New Delhi, India [5/10/10/2011-RHN]
- Department of Science and Technology (DST), New Delhi, India [SR/BO/BB-043/2011]
- ICMR, New Delhi India [3/1/3/JRF-2011/HRD-75, 61102]
Endoglin is a TGF-beta receptor that is expressed in uterine endothelial and stromal cells in addition to trophoblast expression. However, the functional importance of endoglin in the embryo implantation process is not clear. We observed endoglin expression in the endometrium throughout the stages of its receptivity; however, its expression was enhanced during the receptive stage. Endoglin expression was predominant in epithelial cells of the lumen and glands, but showed a milder expression in stromal cells. Endoglin expression was initially observed in the primary decidual zone and later extended to the secondary decidua zone. Knockdown of endoglin via siRNA reduced the implantation sites along with the blastocyst numbers. Mouse blastocyst with endoglin-silenced endometrial epithelial cells (human and mouse origin) showed poor trophoblast outgrowth, which suggests an essential role for endoglin during endometrial receptivity. In conclusion, our findings reveal the association of endoglin with endometrial receptivity, which is important for embryo attachment. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据