Duffy-Null Phenotype-Associated Neutropenia is the Most Common Etiology for Leukopenia/Neutropenia Referrals to a Tertiary Children's Hospital

Duffy-null phenotype-associated neutropenia was present in 77.7% of leukopenia/neutropenia referrals to our center in Detroit with a high prevalence in Yemeni (96.6%), African American (91%), and non-Yemeni Middle Eastern (52.9%) patients. Greater availability of Duffy typing in patients with neutropenia but without recurrent/frequent/ serious infections may lessen the need for additional consultations and investigations.

Automated summary

The Duffy-null phenotype is associated with neutropenia in leukopenia/neutropenia patients referred to our center in Detroit, with a high prevalence observed in Yemeni, African American, and non-Yemeni Middle Eastern patients. Conducting Duffy typing in neutropenic patients without recurrent/frequent/serious infections may reduce the need for additional consultations and investigations.