Oxidative Tandem Cyclization of Glycine Esters with Propargyl Alcohols

A facile and efficient aerobic oxidative (4 + 2)-cyclization/aromatization/lactonizationtandem reaction of N-aryl glycine esters with propargylalcohols to access quinoline-fused lactones is reported. The reactioncan be extended to homopropargylic alcohols too. The transformationis straightforward to perform under mild conditions and scalable,and both reaction components are readily available.

Automated summary

A facile and efficient aerobic oxidative (4 + 2)-cyclization/aromatization/lactonizationtandem reaction of N-aryl glycine esters with propargylalcohols to access quinoline-fused lactones is reported. The reactioncan be extended to homopropargylic alcohols too. The transformationis straightforward to perform under mild conditions and scalable,and both reaction components are readily available.