Salicylaldehyde as an SET-HAT Bifunctional Photocatalyst for the Intermolecular Transalkylation of Phthalimide

Salicylaldehyde works as an efficient photocatalyst for the intermolecular transalkylation of phthalimide. The well-designed dimethyl N-hydroxyphthalimide ester proves to be a good alkylation reagent. It inhibits the competing intramolecular alkylation of alkylating reagent, enabling the site-specific synthesis of N-substituted phthalimide.

Automated summary

Salicylaldehyde is found to be an efficient photocatalyst for the intermolecular transalkylation of phthalimide in this study. The well-designed dimethyl N-hydroxyphthalimide ester serves as a good alkylation reagent, inhibiting the competing intramolecular alkylation of the alkylating reagent and enabling the site-specific synthesis of N-substituted phthalimide.