Merging Electrochemical Synthesis and Post-Ugi Cyclization for the Synthesis of Diverse 4-Imidazolidinones

Despite the appreciation for electro-organic synthesis,postmulticomponentreaction transformation chemistry rarely exploits this powerful technology.Herein, we explore post-Ugi cyclization reactions using N-centeredradical-mediated intramolecular ipso cyclization to synthesize diversespirocyclic variants of 4-imidazolidinones through the use of electrochemicallygenerated amidyl radicals from the bis-amides of the Ugi adducts.This protocol features an undivided cell setup under constant-currentconditions with carbon-platinum electrodes. These metal- andreagent-free reactions are scalable and have broad substrate scope.

Automated summary

In this study, post-Ugi cyclization reactions were explored using N-centered radical-mediated intramolecular ipso cyclization to synthesize diverse spirocyclic variants of 4-imidazolidinones through the use of electrochemically generated amidyl radicals from the bis-amides of the Ugi adducts. This method features metal- and reagent-free reactions that are scalable and have broad substrate scope.