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Erik S. Musiek et al.
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Gabriella Panuccio et al.
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Heela Sarlus et al.
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Juho Joutsa et al.
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Luigi De Gennaro et al.
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Christian Madry et al.
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Lasse Dissing-Olesen et al.
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Yo-El S. Ju et al.
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Clifford R. Jack et al.
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Sang-Sun Yoon et al.
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Brian D. Hitt et al.
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Henrietta M. Nielsen et al.
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Dustin J. Hines et al.
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Rimante Minkeviciene et al.
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Jae-Eun Kang et al.
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Tristan Bolmont et al.
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Melanie Meyer-Luehmann et al.
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Jorge J. Palop et al.
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Xiangyou Hu et al.
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Robert D. Bell et al.
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Sharon E. Haynes et al.
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Holly Oakley et al.
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JC Amatniek et al.
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D Davalos et al.
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A Nimmerjahn et al.
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R Lalonde et al.
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RA Del Vecchio et al.
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D Petit et al.
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MF Mendez et al.
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J Rogers et al.
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