The T1-weighted/T2-weighted ratio as a biomarker of anti-NMDA receptor encephalitis

Letter Clinical Neurology

In Vivo N-Methyl-D-Aspartate Receptor (NMDAR) Density as Assessed Using Positron Emission Tomography During Recovery From NMDAR-Antibody Encephalitis

Marian Galovic et al.

Summary: This study investigates the changes in N-methyl-d-aspartate receptor (NMDAR) density during the recovery from NMDAR-antibody encephalitis using a radiotracer and positron emission tomography.

JAMA NEUROLOGY (2023)

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Review Neurosciences

A narrative review of the anatomy and function of the white matter tracts in language production and comprehension

Ehsan Shekari et al.

Summary: This study provides a comprehensive review of the role of white matter in connecting cortical areas involved in language processing. Hypotheses about the functions of major tracts connecting these areas are evaluated using data from studies in neurotypical individuals, neuropsychological data, and intraoperative stimulation studies. The study highlights the conclusions supported by the data and identifies areas requiring further investigation.

FRONTIERS IN HUMAN NEUROSCIENCE (2023)

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Article Clinical Neurology

Networks of microstructural damage predict disability in multiple sclerosis

Elisa Colato et al.

Summary: Network-based measures of white and grey matter damage can predict disability progression and cognitive worsening in multiple sclerosis (MS). This study has important implications for identifying patients at risk of disease worsening and for stratifying cohorts in treatment trials.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2023)

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Article Clinical Neurology

State-dependent signatures of anti-N-methyl-d-aspartate receptor encephalitis

Nina von Schwanenflug et al.

Summary: The study used a dynamic functional connectivity approach to investigate the spatiotemporal variability of brain network activity in patients with anti-N-methyl-D-aspartate receptor encephalitis. The results showed distinct alterations in functional connectivity, dwell time patterns, and state transitions in patients compared to controls. The predictive power of dynamic functional connectivity models outperformed static analyses.

BRAIN COMMUNICATIONS (2022)

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Article Clinical Neurology

Neuropathological Variability within a Spectrum of NMDAR-Encephalitis

Tobias Zrzavy et al.

Summary: This study describes the neuropathological features of NMDAR encephalitis in an autopsy cohort, revealing that inflammation predominantly affects the basal ganglia, amygdala, and hippocampus, and the loss of NMDAR immunoreactivity correlates with disease severity. Additionally, co-occurring pathologies influence the spatial distribution, composition, and intensity of inflammation, potentially modifying patients' clinical presentation and outcome.

ANNALS OF NEUROLOGY (2021)

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Article Clinical Neurology

Long-Term Cognitive Outcome in Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Josephine Heine et al.

Summary: Cognitive dysfunction is a core symptom of anti-NMDAR encephalitis, with memory and executive function being the main deficits. Despite cognitive deficits persisting beyond functional neurological recovery, improvement in cognitive function is possible for several years after onset. Delayed treatment, higher disease severity, and longer duration of the acute phase are predictors for impaired cognitive outcome.

ANNALS OF NEUROLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Magnetic resonance T1w/T2w ratio in the middle cerebellar peduncle might be a sensitive biomarker for multiple system atrophy

Atsuhiko Sugiyama et al.

Summary: The study demonstrates that the sT1w/T2w ratio can detect MSA-C-related changes in the MCP, even in the early stages of the disorder, making it a sensitive biomarker for MSA-C.

EUROPEAN RADIOLOGY (2021)

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Article Clinical Neurology

Longitudinal analysis of T1w/T2w ratio in patients with multiple sclerosis from first clinical presentation

Graham Cooper et al.

Summary: The study found that the decrease in NAWM integrity was associated with cortical thickness and increasing lesion burden over time. The results suggest that sT1w/T2w may be a useful MRI biomarker for early MS, detecting relevant NAWM damage over time using conventional MRI scans, although with less sensitivity compared to quantitative measures.

MULTIPLE SCLEROSIS JOURNAL (2021)

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Article Clinical Neurology

Long-term Functional Outcomes and Relapse of Anti-NMDA Receptor Encephalitis A Cohort Study in Western China

Xue Gong et al.

Summary: The study in Western China on anti-NMDA receptor encephalitis found that most patients experienced favorable long-term functional outcomes, with some experiencing relapses, especially among female patients. Timely immunotherapy at onset may reduce the risk of relapse.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)

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Article Clinical Neurology

Anti-NMDAR encephalitis: A single-center, longitudinal study in China

Xiaolu Xu et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2020)

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Article Clinical Neurology

N-Methyl-D-Aspartate Receptor Antibodies in Autoimmune Encephalopathy Alter Oligodendrocyte Function

Carlos Matute et al.

ANNALS OF NEUROLOGY (2020)

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Article Clinical Neurology

Clinical and Magnetic Resonance Imaging Outcome Predictors in Pediatric Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Frederik Bartels et al.

ANNALS OF NEUROLOGY (2020)

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Article Clinical Neurology

Validation of the NEOS score in Chinese patients with anti-NMDAR encephalitis

Yujing Peng et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2020)

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Article Neurosciences

Quantitative Multi-Parameter Mapping Optimized for the Clinical Routine

Graham Cooper et al.

FRONTIERS IN NEUROSCIENCE (2020)

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Article Neuroimaging

Transdiagnostic hippocampal damage patterns in neuroimmunological disorders

Josephine Heine et al.

NEUROIMAGE-CLINICAL (2020)

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Article Clinical Neurology

Standardization of T1w/T2w Ratio Improves Detection of Tissue Damage in Multiple Sclerosis

Graham Cooper et al.

FRONTIERS IN NEUROLOGY (2019)

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Review Clinical Neurology

An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models

Josep Dalmau et al.

LANCET NEUROLOGY (2019)

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Article Clinical Neurology

Long-term cognitive and neuropsychiatric outcomes in patients with anti-NMDAR encephalitis

Xu Liu et al.

ACTA NEUROLOGICA SCANDINAVICA (2019)

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Article Clinical Neurology

A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis

Ramani Balu et al.

NEUROLOGY (2019)

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Article Clinical Neurology

Superficial white matter damage in anti-NMDA receptor encephalitis

Owen Robert Phillips et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2018)

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Review Clinical Neurology

Magnetic resonance imaging and positron emission tomography in anti-NMDA receptor encephalitis: A systematic review

Stephen Bacchi et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2018)

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Review Medicine, General & Internal

Antibody-Mediated Encephalitis

Josep Dalmau et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Neurosciences

Evidence for Functional Networks within the Human Brain's White Matter

Michael Peer et al.

JOURNAL OF NEUROSCIENCE (2017)

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Article Neurosciences

Structural Hippocampal Damage Following Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Carsten Finke et al.

BIOLOGICAL PSYCHIATRY (2016)

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Article Psychiatry

Hypoglutamatergic state is associated with reduced cerebral glucose metabolism in anti-NMDA receptor encephalitis: a case report

Dominique Endres et al.

BMC PSYCHIATRY (2015)

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Review Neurosciences

IMAGING OF AUTOIMMUNE ENCEPHALITIS - RELEVANCE FOR CLINICAL PRACTICE AND HIPPOCAMPAL FUNCTION

J. Heine et al.

NEUROSCIENCE (2015)

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Article Radiology, Nuclear Medicine & Medical Imaging

Contrast Enhancement by Combining T1-and T2-Weighted Structural Brain MR Images

Masaya Misaki et al.

MAGNETIC RESONANCE IN MEDICINE (2015)

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Article Clinical Neurology

Functional and Structural Brain Changes in Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Carsten Finke et al.

ANNALS OF NEUROLOGY (2013)

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Article Biochemistry & Molecular Biology

Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes

Iben Lundgaard et al.

PLOS BIOLOGY (2013)

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Article Clinical Neurology

Cognitive deficits following anti-NMDA receptor encephalitis

Carsten Finke et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2012)

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Article Clinical Neurology

Fluorodeoxyglucose positron emission tomography in anti-N-methyl-D-aspartate receptor encephalitis: distinct pattern of disease

Frank Leypoldt et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2012)

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Review Neurosciences

FSL

Mark Jenkinson et al.

NEUROIMAGE (2012)

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Article Neurosciences

An automated tool for detection of FLAIR-hyperintense white-matter lesions in Multiple Sclerosis

Paul Schmidt et al.

NEUROIMAGE (2012)

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Article Biochemical Research Methods

pROC: an open-source package for R and S plus to analyze and compare ROC curves

Xavier Robin et al.

BMC BIOINFORMATICS (2011)

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Article Neurosciences

Mapping Human Cortical Areas In Vivo Based on Myelin Content as Revealed by T1- and T2-Weighted MRI

Matthew F. Glasser et al.

JOURNAL OF NEUROSCIENCE (2011)

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Review Clinical Neurology

Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis

Josep Dalmau et al.

LANCET NEUROLOGY (2011)

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Article Computer Science, Interdisciplinary Applications

N4ITK: Improved N3 Bias Correction

Nicholas J. Tustison et al.

IEEE TRANSACTIONS ON MEDICAL IMAGING (2010)

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Article Clinical Neurology

Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies

Josep Dalmau et al.

LANCET NEUROLOGY (2008)

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Article Neurosciences

Dorsolateral prefrontal cortex promotes long-term memory formation through its role in working memory organization

RS Blumenfeld et al.

JOURNAL OF NEUROSCIENCE (2006)

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Article Neurosciences

Advances in functional and structural MR image analysis and implementation as FSL

SM Smith et al.

NEUROIMAGE (2004)

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Article Computer Science, Artificial Intelligence

A global optimisation method for robust affine registration of brain images

M Jenkinson et al.

MEDICAL IMAGE ANALYSIS (2001)

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The T1-weighted/T2-weighted ratio as a biomarker of anti-NMDA receptor encephalitis

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