Prognostic significance of peripheral neutrophils and lymphocytes in early untreated Parkinson's disease: an 8-year follow-up study

Article Neurosciences

High neutrophil-to-lymphocyte ratio predicts short survival in multiple system atrophy

LingYu Zhang et al.

Summary: The neutrophil-to-lymphocyte ratio (NLR) is associated with poor prognosis in patients with multiple system atrophy (MSA), particularly in those with MSA-C subtype and in men.

NPJ PARKINSONS DISEASE (2022)

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Article Hematology

Soluble uric acid inhibits β2 integrin-mediated neutrophil recruitment in innate immunity

Qiuyue Ma et al.

Summary: This study investigates the impact of uric acid on neutrophils and finds that hyperuricemia impairs neutrophil function. Partial reduction of uric acid levels using uricase can partially restore the neutrophil defects. The study reveals that uric acid affects neutrophil migration by regulating intracellular pH and cytoskeletal dynamics. These findings have important implications for understanding immunodeficiency in kidney disease and sterile inflammation.

BLOOD (2022)

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Article Clinical Neurology

Serum Inflammatory Markers and Progression of Nonmotor Symptoms in Early Parkinson's Disease

Ryul Kim et al.

Summary: This study found that peripheral inflammation in early-stage Parkinson's disease (PD) may be related to the progression of nonmotor symptoms (NMSs), particularly mood symptoms. By measuring six inflammatory markers, the researchers found that elevated levels of IL-2 and IL-6 were associated with the progression of NMSs.

MOVEMENT DISORDERS (2022)

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Review Neurosciences

Epidemiological Evidence for an Immune Component of Parkinson's Disease

Paulina Gonzalez-Latapi et al.

Summary: There is a growing interest in understanding the role of the immune system and inflammatory response in the development of Parkinson's disease. Epidemiological evidence suggests that Parkinson's disease may be immune-mediated, with associations observed between inflammatory bowel disease and an increased risk of Parkinson's. Medications that suppress the immune system may decrease the risk of Parkinson's, and there are shared genetic variants between Parkinson's and autoimmune conditions. Further research is needed to fully understand the relationship between the immune system and Parkinson's disease.

JOURNAL OF PARKINSONS DISEASE (2022)

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Article Immunology

Insulin-Like Growth Factor 1 Attenuates the Pro-Inflammatory Phenotype of Neutrophils in Myocardial Infarction

Rianne Nederlof et al.

Summary: IGF1 treatment induces an anti-inflammatory phenotype in bone marrow derived neutrophils and attenuates inflammation after myocardial infarction (MI). The effect of IGF1 is mediated through the JAK2/STAT6 pathway rather than the canonical Ras/Raf/ERK or PI3K/AKT pathway. Single cell sequencing analysis shows that IGF1 treatment downregulates pro-inflammatory genes and upregulates anti-inflammatory genes in neutrophils and macrophages after MI.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Inflammation and immune dysfunction in Parkinson disease

Malu Gamez Tansey et al.

Summary: This review explores the role of an ageing immune system, host genetics, and exposure to environmental stressors in promoting the development of Parkinson's disease. It discusses the presence of neuroinflammation and alterations in immune cell populations as well as the potential contributions of viral or bacterial exposure, pesticides, and gut microbiota to disease pathogenesis.

NATURE REVIEWS IMMUNOLOGY (2022)

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Article Clinical Neurology

Lower Lymphocyte Count is Associated With Increased Risk of Parkinson's Disease

Melanie P. Jensen et al.

Summary: Lower lymphocyte count is associated with an increased risk of subsequent Parkinson's disease. Other blood markers, such as reductions in eosinophil counts, monocyte counts, and C-reactive protein, may also be related to increased disease risk, but only the association with lower lymphocyte count remains robust. Mendelian randomization analysis suggests a potential causal relationship between lower lymphocyte count and Parkinson's disease risk.

ANNALS OF NEUROLOGY (2021)

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Article Clinical Neurology

Peripheral Immune Profile and Neutrophil-to-Lymphocyte Ratio in Parkinson's Disease

Laura Munoz-Delgado et al.

Summary: Parkinson's disease patients exhibit altered peripheral immune profiles and higher neutrophil-to-lymphocyte ratio (NLR) compared to healthy controls. However, there appears to be no significant association between NLR and clinical characteristics of Parkinson's disease. A meta-analysis also suggests higher NLR in Parkinson's disease patients.

MOVEMENT DISORDERS (2021)

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Review Immunology

The emerging role of neutrophils in neurodegeneration

Barbara Rossi et al.

IMMUNOBIOLOGY (2020)

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Article Clinical Neurology

Differential leukocyte count is associated with clinical phenotype in Parkinson's disease

Tadashi Umehara et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2020)

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Article Clinical Neurology

The neutrophil-to-lymphocyte ratio as a marker of peripheral inflammation in progressive supranuclear palsy: a retrospective study

Ipek Inci et al.

NEUROLOGICAL SCIENCES (2020)

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Article Clinical Neurology

Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease

Daniel Weintraub et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

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Review Clinical Neurology

Parkinson disease and the immune system - associations, mechanisms and therapeutics

Eng-King Tan et al.

NATURE REVIEWS NEUROLOGY (2020)

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Review Immunology

The neutrophil-to-lymphocyte ratio in Alzheimer's disease: Current understanding and potential applications

Ahmed Sayed et al.

JOURNAL OF NEUROIMMUNOLOGY (2020)

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Review Physiology

THE NEUTROPHIL'S ROLE DURING HEALTH AND DISEASE

Pei Xiong Liew et al.

PHYSIOLOGICAL REVIEWS (2019)

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Review Immunology

Metabolic Insight of Neutrophils in Health and Disease

Sachin Kumar et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Cell Biology

The Brain Entangled: The Contribution of Neutrophil Extracellular Traps to the Diseases of the Central Nervous System

Aneta Manda-Handzlik et al.

CELLS (2019)

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Article Clinical Neurology

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

Mike A. Nalls et al.

LANCET NEUROLOGY (2019)

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Article Neurosciences

Parkinson's progression prediction using machine learning and serum cytokines

Diba Ahmadi Rastegar et al.

NPJ PARKINSONS DISEASE (2019)

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Article Clinical Neurology

Presynaptic striatal dopaminergic depletion predicts the later development of freezing of gait in de novo Parkinson's disease: An analysis of the PPMI cohort

Ryul Kim et al.

PARKINSONISM & RELATED DISORDERS (2018)

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Article Clinical Neurology

Association Between Peripheral Inflammation and DATSCAN Data of the Striatal Nuclei in Different Motor Subtypes of Parkinson Disease

Hossein Sanjari Moghaddam et al.

FRONTIERS IN NEUROLOGY (2018)

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Article Clinical Neurology

Immunosuppressants and risk of Parkinson disease

Brad A. Racette et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2018)

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Article Clinical Neurology

Developing and validating Parkinson's disease subtypes and their motor and cognitive progression

Michael Lawton et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2018)

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Review Immunology

Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

Xi Chen et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Clinical Neurology

The Parkinson's progression markers initiative (PPMI) - establishing a PD biomarker cohort

Kenneth Marek et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2018)

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Article Medicine, General & Internal

Serum neutrophil-lymphocyte ratios, C-reactive protein and sedimentation levels in Parkinson's disease

Volkan Solmaz et al.

CUKUROVA MEDICAL JOURNAL (2018)

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Article Clinical Neurology

High neutrophil to lymphocyte ratio is associated with white matter hyperintensity in a healthy population

Ki-Woong Nam et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)

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Correction Multidisciplinary Sciences

T cells from patients with Parkinson's disease recognize α-synuclein peptides (vol 546, pg 656, 2017)

David Sulzer et al.

NATURE (2017)

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Review Clinical Neurology

The correlation of lymphocyte subsets, natural killer cell, and Parkinson's disease: a meta-analysis

Sen Jiang et al.

NEUROLOGICAL SCIENCES (2017)

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Article Multidisciplinary Sciences

Parkinson's disease-associated genetic variation is linked to quantitative expression of inflammatory genes

Steven Pierce et al.

PLOS ONE (2017)

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Review Immunology

Neutrophils as protagonists and targets in chronic inflammation

Oliver Soehnlein et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Article Clinical Neurology

Serum immune markers and disease progression in an incident Parkinson's disease cohort (ICICLE-PD)

Caroline H. Williams-Gray et al.

MOVEMENT DISORDERS (2016)

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Article Clinical Neurology

Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease A Systematic Review and Meta-analysis

Xiao-Yan Qin et al.

JAMA NEUROLOGY (2016)

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Article Biochemistry & Molecular Biology

Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation

Yasuyuki Arai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

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Review Immunology

Neutrophil-derived cytokines: facts beyond expression

Cristina Tecchio et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Review Oncology

The systemic inflammation-based neutrophil-lymphocyte ratio: Experience in patients with cancer

Graeme J. K. Guthrie et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2013)

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Article Neurosciences

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology

Isaac M. Chiu et al.

NATURE NEUROSCIENCE (2012)

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Review Neurosciences

The Parkinson Progression Marker Initiative (PPMI)

Kenneth Marek et al.

PROGRESS IN NEUROBIOLOGY (2011)

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Article Geriatrics & Gerontology

Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-α-dependent

Yi-Jun Liu et al.

NEUROBIOLOGY OF AGING (2010)

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Article Clinical Neurology

Anti-inflammatory drugs and risk of Parkinson disease A meta-analysis

Joshua J. Gagne et al.

NEUROLOGY (2010)

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Article Clinical Neurology

The MoCA Well-suited screen for cognitive impairment in Parkinson disease

J. C. Dalrymple-Alford et al.

NEUROLOGY (2010)

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Article Medicine, Research & Experimental

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

Vanessa Brochard et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

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Article Clinical Neurology

Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease

S. Hoops et al.

NEUROLOGY (2009)

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Article Neurosciences

Resident microglia die and infiltrated neutrophils and monocytes become major inflammatory cells in lipopolysaccharide-injected brain

Kyung-Ae Ji et al.

GLIA (2007)

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Article Cardiac & Cardiovascular Systems

Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models

Kelly H. Zou et al.

CIRCULATION (2007)

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Prognostic significance of peripheral neutrophils and lymphocytes in early untreated Parkinson's disease: an 8-year follow-up study

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