Pathological findings in autoimmune encephalitis autopsy specimens from cases of suspected prion disease

Article Clinical Neurology

Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes

Woo Jin Lee et al.

Summary: This institutional cohort study examines the clinical characteristics, disease course, effectiveness of immunotherapy, and prognostic factors in patients with seronegative autoimmune encephalitis. Combination immunotherapy with steroids, immunoglobulin, rituximab, and tocilizumab was associated with improved outcomes.

BRAIN (2022)

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Article Clinical Neurology

Residual symptoms and long-term outcomes after all-cause autoimmune encephalitis in adults

Hesham Abboud et al.

Summary: This study evaluated residual symptoms and long-term treatment outcomes in patients with autoimmune encephalitis. The majority of patients showed improvement after treatment, but some had poor outcomes. The most common residual symptoms were cognitive and mood dysfunction.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2022)

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Review Clinical Neurology

Autoimmune encephalitis: proposed best practice recommendations for diagnosis and acute management

Hesham Abboud et al.

Summary: This paper evaluates evidence and expert opinions in the management of autoimmune encephalitis, presenting choices for first-line and second-line therapies based on survey responses from clinicians worldwide. The preferences for corticosteroids and rituximab as treatments are highlighted, with a focus on individual responses and the consensus among the surveyed members.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

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Review Clinical Neurology

Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease

Peter Hermann et al.

Summary: Sporadic Creutzfeldt-Jakob disease is a fatal neurodegenerative disease caused by misfolded prion proteins. Its diagnosis relies on a combination of neuropsychiatric symptoms, CSF markers, and imaging. The development of assays like RT-QuIC has improved diagnostic accuracy.

LANCET NEUROLOGY (2021)

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Article Immunology