Inclusion body myositis with early onset: a population-based study

Article Clinical Neurology

Clinical Subgroups and Factors Associated With Progression in Patients With Inclusion Body Myositis

Elizabeth Harlan Michelle et al.

Summary: This study found that female and non-Black patients with IBM have distinct clinical phenotypes, which may have different responses to therapies and can influence the design of future clinical trials in IBM.

NEUROLOGY (2023)

添加到收藏夹

Article Clinical Neurology

Epidemiology, Survival, and Clinical Characteristics of Inclusion Body Myositis

Ulrika Lindgren et al.

Summary: This population-based study investigated the prevalence, survival rate, and incidence of inclusion body myositis over a 33-year period in the Vastra Gotaland region of Sweden. The study also explored the symptom profiles associated with disease duration and sex. The results showed that inclusion body myositis is an autoimmune disease with decreased survival rate and marked sex differences in both prevalence and clinical manifestations.

ANNALS OF NEUROLOGY (2022)

添加到收藏夹

Article Rheumatology

Survival and associated comorbidities in inclusion body myositis

Elie Naddaf et al.

Summary: This study evaluated the survival and associated comorbidities in inclusion body myositis (IBM) patients. The results showed that IBM was associated with lower survival, and higher frequency of peripheral neuropathy, Sjogren's syndrome, and hematologic malignancies.

RHEUMATOLOGY (2022)

添加到收藏夹

Article Clinical Neurology

Atypical presentations of inclusion body myositis: Clinical characteristics and long-term outcomes

Mazen Alamr et al.

Summary: This study retrospectively analyzed 357 IBM patients with 14% of them having atypical presentations. Dysphagia (50%), asymptomatic hyperCKemia (24%), and foot drop (12%) were the most common atypical presentations. The median time from symptom onset to diagnosis was 9 years, and the median age at diagnosis was 70.5 years. Most patients showed worsening symptoms during follow-up.

MUSCLE & NERVE (2022)

添加到收藏夹

Article Clinical Neurology

Mitochondrial DNA variants in inclusion body myositis characterized by deep sequencing

Carola Hedberg-Oldfors et al.

Summary: Deep sequencing and quantitation of mtDNA variants in muscle samples from IBM patients and controls revealed significantly increased levels of large deletions and duplications in IBM muscles, as well as indications of increased somatic single nucleotide variants and reduced mtDNA copy numbers compared to controls. The distribution and types of variants were similar in IBM muscle and controls, suggesting an accelerated aging process in IBM muscle possibly associated with chronic inflammation.

BRAIN PATHOLOGY (2021)

添加到收藏夹

Article Clinical Neurology

Epidemiology and Natural History of Inclusion Body Myositis: A 40-Year Population-Based Study

Shahar Shelly et al.

Summary: This study in Olmsted County found that patients with sIBM have a similar risk of cancers but slightly shorter life expectancy compared to the general population. It provides Class II evidence supporting this conclusion.

NEUROLOGY (2021)

添加到收藏夹

Article Genetics & Heredity