Yin Yang 1 suppresses apoptosis and oxidative stress injury in SH-SY5Y cells by facilitating NR4A1 expression

Article Geriatrics & Gerontology

NR4A1 promotes oxidative stresses after myocardial ischemia reperfusion injury in aged mice

Xue Peng et al.

Summary: NR4A1 deficiency can attenuate oxidative stress in aged MI mice and improve myocardial function.

EXPERIMENTAL GERONTOLOGY (2022)

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Review Clinical Neurology

The neuropsychiatry of Parkinson's disease: advances and challenges

Daniel Weintraub et al.

Summary: Neuropsychiatric signs and symptoms are common in people with Parkinson's disease, and their underlying neurobiology is complex. Identifying risk factors and developing effective treatments require further research and specialized care models.

LANCET NEUROLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Nuclear receptor Nur77 protects against oxidative stress by maintaining mitochondrial homeostasis via regulating mitochondrial fission and mitophagy in smooth muscle cell

Na Geng et al.

Summary: The nuclear receptor NR4A1 plays an important role in AngII-induced oxidative stress and mitochondrial dynamics in VSMCs. Nur77 deficiency exacerbates AngII-induced oxidative stress and mitochondrial dynamics disruption in VSMCs, while its activation alleviates them. Nur77 inhibits mitochondrial fission by repressing the transcription of Fis1 and Drp1, and promotes mitochondrial homeostasis by increasing mitophagic flux.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2022)

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Article Biochemistry & Molecular Biology

NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

Hongsha Guo et al.

Summary: The deregulation of oncogenic signals in cancer triggers replication stress, which leads to the inhibition of IEG gene transcription by NR4A1. This results in proliferative failure and chromosomal instability, highlighting the potential role of NR4A1 in cancer progression.

MOLECULAR CELL (2021)

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Article Neurosciences

Naringenin alleviates paraquat-induced dopaminergic neuronal loss in SH-SY5Y cells and a rat model of Parkinson's disease

Mir Hilal Ahmad et al.

Summary: Naringenin (NAR) exhibits neuroprotection against PQ-induced neurotoxicity and neurodegeneration, indicating its novel therapeutic potential against PD.

NEUROPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

YAF2-Mediated YY1-Sirtuin6 Interactions Responsible for Mitochondrial Downregulation in Aging Tunicates

Kaz Kawamura et al.

Summary: In budding tunicates, aging is associated with a decrease in mitochondrial respiratory activity due to decreased Tfam gene expression, which can be improved by the transfection of synthetic mRNA of YY1 and Sirt6. This study indicates that YY1 and Sirt6 play important roles in regulating mitochondrial function during aging in budding tunicates.

MOLECULAR AND CELLULAR BIOLOGY (2021)

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Review Oncology

Targeting BCL-2 in Cancer: Advances, Challenges, and Perspectives

Shirin Hafezi et al.

Summary: Apoptosis is the main form of cell death regulated by the BCL-2 family of proteins. Overexpression of antiapoptotic proteins in malignant cells offers survival advantages but also presents opportunities for targeted therapies. Studies targeting BCL-2 proteins, including the development of venetoclax, show promise for effective treatment in cancer.

CANCERS (2021)

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Review Biochemistry & Molecular Biology

Treatment Options for Motor and Non-Motor Symptoms of Parkinson's Disease

Frank C. Church

Summary: Parkinson's disease is a progressive neurodegenerative disorder that mainly affects older adults. Treatment options include rehabilitation, therapy, restorative programs, maintenance with complementary and alternative medicine, and surgery as a last resort. Currently, there is no cure for PD and the focus is on slowing disease progression and improving quality of life for patients.

BIOMOLECULES (2021)

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Article Cell & Tissue Engineering

Roles Played by YY1 in Embryonic, Adult and Cancer Stem Cells

Gustavo Ulises Martinez-Ruiz et al.

Summary: The text highlights the relationship between the presence of cancer stem cells and worsened clinical outcomes, as well as the role of YY1 in regulating the phenotype of cancer stem cells.

STEM CELL REVIEWS AND REPORTS (2021)

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Article Cell Biology