Preface: Special issue Brain Proteostasis in Health and Disease

This preface introduces the Journal of Neurochemistry Special Issue on Brain Proteostasis. Adequate control of protein homeostasis, or proteostasis, has been at the center stage of brain physiology, and its deregulation may contribute to brain diseases, including several neuropsychiatric and neurodegenerative conditions. Therefore, delineating the processes underlying protein synthesis, folding, stability, function, and degradation in brain cells is key to promoting brain function and identifying effective therapeutic options for neurological disorders. This special issue comprises four review articles and four original articles covering the roles of protein homeostasis in several mechanisms that are of relevance to sleep, depression, stroke, dementia, and COVID-19. Thus, these articles highlight different aspects of proteostasis regulation in the brain and present important evidence on this growing and exciting field.

Automated summary

This preface introduces a special issue of the Journal of Neurochemistry on Brain Proteostasis. Proper control of protein homeostasis is crucial for brain physiology and its imbalance can contribute to various neurological and neurodegenerative disorders. Understanding the processes involved in protein synthesis, folding, stability, function, and degradation in brain cells is essential for promoting brain function and finding effective therapies for neurological disorders. This special issue includes review and original articles that explore the roles of protein homeostasis in sleep, depression, stroke, dementia, and COVID-19, providing important insights into this growing and exciting field.