☆ 4.5 Article

Trem2 deficiency attenuates microglial phagocytosis and autophagic-lysosomal activation in white matter hypoperfusion

JOURNAL OF NEUROCHEMISTRY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Neurosciences

Autophagy regulates inflammation in intracerebral hemorrhage: Enemy or friend?

Kaijing Fu et al.

Summary: Intracerebral hemorrhage (ICH) is a significant contributor to stroke-related mortality and disability. Secondary brain injury (SBI) following ICH is mainly caused by inflammation, oxidative stress, and excitotoxicity. Autophagy, a cellular mechanism for maintaining homeostasis, has a complex role in the pathology of ICH.

FRONTIERS IN CELLULAR NEUROSCIENCE (2023)

添加到收藏夹

Article Multidisciplinary Sciences

TREM2 has a significant, gender-specific, effect on human obesity

Tzila Reich et al.

Summary: A computational study using public databases provides direct evidence for the involvement of TREM2 in human obesity. TREM2 expression levels in adipose tissues show a significant correlation with BMI, especially in males. A coding SNP in TREM2 is identified to have a significant effect on BMI, particularly in females.

SCIENTIFIC REPORTS (2023)

添加到收藏夹

Editorial Material Cell Biology

Haste makes waste: staged suppression of autophagic-lysosomal pathway in microglia promotes the efficient clearance of myelin debris

Chuan Qin et al.

Summary: The autophagic-lysosomal pathway in microglia is crucial for removing myelin debris in white matter damage. However, the regulation of this pathway and maintaining lipid metabolism balance are still unclear. Excessive activation of autophagy causes lipid overload and accumulation in lysosomes and lipid droplets, leading to microglial dysfunction and secondary white matter damage. Suppression of autophagic activation in the acute phase of demyelination benefits microglia by restoring lipid metabolism balance and promoting myelin debris removal. Neuroprotective effects of microglial autophagy regulation may involve intracellular linoleic acid (LA) production and activation of the PPARG pathway.

AUTOPHAGY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Myeloid Trem2 Dynamically Regulates the Induction and Resolution of Hepatic Ischemia-Reperfusion Injury Inflammation

Sheng Han et al.

Summary: Trem2 plays a complex and heterogeneous role in liver inflammation, with its function changing at different stages. In the early stage of inflammation induction after hepatic ischemia-reperfusion (IR), myeloid Trem2 deletion inhibits the induction of inflammatory markers and reduces neutrophil accumulation and mitochondrial damage. However, as pro-inflammatory macrophages transition into resolution macrophages, Trem2 promotes phagocytosis of apoptotic cells, contributing to the resolution of inflammation. Overexpression of myeloid Trem2 accelerates the transition of monocytes to a resolution phenotype, while knockdown of Trem2 delays upregulation of certain markers. Overall, Trem2 is involved in the cascade of IR inflammation in a two-sided capacity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer's disease

Dhanshree Jha et al.

Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia in the elderly. NLRP3 inflammasome has been identified as a critical mediator of neuroinflammation, and inhibiting NLRP3 activation can alleviate AD-related pathology. Several synthetic and natural compounds have shown potential in inhibiting NLRP3 inflammasome and could be used as therapeutic interventions for AD.

JOURNAL OF NEUROCHEMISTRY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

Francois Le Guerroue et al.

Summary: This study reveals that TNIP1 acts as a negative regulator of mitophagy, which is a selective autophagy process. TNIP1 interacts with the LC3/GABARAP family of proteins and the autophagy receptor TAX1BP1, and competes with autophagy receptors by binding with the ULK1 complex member FIP200. These findings provide insights into the early steps of autophagosome biogenesis during mitophagy.

MOLECULAR CELL (2023)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

Editorial: Role of microglia autophagy in age-related neurodegenerative diseases

Zihua Wang

FRONTIERS IN AGING NEUROSCIENCE (2023)

添加到收藏夹

Article Immunology

Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 inflammasome

Reham A. Ammar et al.

Summary: Liraglutide exerts neuroprotection in multiple sclerosis through its anti-inflammatory, autophagic flux activation, NLRP3 inflammasome suppression, and anti-apoptotic mechanisms.

INFLAMMOPHARMACOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Staged suppression of microglial autophagy facilitates regeneration in CNS demyelination by enhancing the production of linoleic acid

Luo-Qi Zhou et al.

Summary: It has been found that in the demyelination process, the autophagic-lysosomal pathway in microglia is overactivated, leading to their dysfunction and pro-inflammatory state, resulting in failed myelin debris clearance and spatial learning deficits. Suppression of excessive autophagic-lysosomal activation can improve myelin debris degradation, while supplementation with linoleic acid can attenuate inflammation and restore microglial pro-regenerative properties, ultimately promoting recovery from demyelination injuries and improving spatial learning function.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

添加到收藏夹

Article Immunology

The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke

Wen-yu Ma et al.

Summary: This study summarizes the functional changes of TREM2 in microglia after stroke, indicating that TREM2 has significant effects on energy metabolism, phagocytosis, and anti-inflammatory function of microglia after stroke, suggesting that TREM2 is a potential therapeutic target for the treatment of stroke.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Article Neurosciences

Microglial mTOR Activation Upregulates Trem2 and Enhances ?-Amyloid Plaque Clearance in the5XFADAlzheimer?s Disease Model

Qian Shi et al.

Summary: This study reveals the critical link between mTOR signaling and Trem2 regulation and lysosomal biogenesis in microglia. Activation of mTOR in microglia upregulates Trem2 expression, enhances Ab clearance, reduces spine loss, and improves cognitive function. However, in Alzheimer's disease, excessive activation of mTOR leads to decreased Trem2 expression, reduced Ab clearance, and increased Ab plaque burden.

JOURNAL OF NEUROSCIENCE (2022)

添加到收藏夹

Article Cell Biology

FTY720 Modulates Microglia Toward Anti-inflammatory Phenotype by Suppressing Autophagy via STAT1 Pathway

Zi-Wei Hu et al.

Summary: The study demonstrates that FTY720 can transform pro-inflammatory microglia into anti-inflammatory microglia by inhibiting autophagy and STAT1 activity.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Unique Phenotype of Lipid-Laden Macrophages

Marco van Eijk et al.

Summary: Macrophages are versatile cells in the innate immune system, equipped with receptors for damage and pathogen recognition. They have systems for uptake of extracellular and intracellular cargo, and lysosomes play a central role in digestion and nutrient entry. Lipid accumulation leads to a unique metabolic activation phenotype in macrophages.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Cell Biology

Lysosomes as dynamic regulators of cell and organismal homeostasis

Andrea Ballabio et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

添加到收藏夹

Article Neurosciences

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

Alicia A. Nugent et al.

NEURON (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Melatonin attenuates choroidal neovascularization by regulating macrophage/microglia polarization via inhibition of RhoA/ROCK signaling pathway

Yue Xu et al.

JOURNAL OF PINEAL RESEARCH (2020)

添加到收藏夹

Article Clinical Neurology

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Francesca Cignarella et al.

ACTA NEUROPATHOLOGICA (2020)

添加到收藏夹

Article Immunology

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model

Shoutang Wang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

添加到收藏夹

Article Cell Biology

TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice

Yaping Wang et al.

AGING-US (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

Wenfei Liu et al.

HUMAN MOLECULAR GENETICS (2020)

添加到收藏夹

Article Immunology

Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model

Man Chen et al.

JOURNAL OF NEUROINFLAMMATION (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Depletion of microglia ameliorates white matter injury and cognitive impairment in a mouse chronic cerebral hypoperfusion model

Masashi Kakae et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

添加到收藏夹

Article Neurosciences

Autophagy inhibition exerts neuroprotection on white matter ischemic damage after chronic cerebral hypoperfusion in mice

Shuo-Qi Zhang et al.

BRAIN RESEARCH (2019)

添加到收藏夹

Article Neurosciences

TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion

Jun Miyanohara et al.

JOURNAL OF NEUROSCIENCE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Defective cholesterol clearance limits remyelination in the aged central nervous system

Ludovico Cantuti-Castelvetri et al.

SCIENCE (2018)

添加到收藏夹

Review Clinical Neurology

TREM2-a key player in microglial biology and Alzheimer disease

Tyler K. Ulland et al.

NATURE REVIEWS NEUROLOGY (2018)

添加到收藏夹

Review Immunology

Microglia and macrophages in brain homeostasis and disease

Qingyun Li et al.

NATURE REVIEWS IMMUNOLOGY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway

Chuan Qin et al.

THERANOSTICS (2018)

添加到收藏夹

Article Clinical Neurology

An updated histological classification system for multiple sclerosis lesions

Tanja Kuhlmann et al.

ACTA NEUROPATHOLOGICA (2017)

添加到收藏夹

Article Critical Care Medicine

Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury

Maha Saber et al.

JOURNAL OF NEUROTRAUMA (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Perilipins: a diversity of intracellular lipid droplet proteins

Hiroyuki Itabe et al.

LIPIDS IN HEALTH AND DISEASE (2017)

添加到收藏夹

Review Neurosciences

TREM2 in Neurodegenerative Diseases

Taylor R. Jay et al.

MOLECULAR NEURODEGENERATION (2017)

添加到收藏夹

Review Neurosciences

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

Fiona M. Menzies et al.

NEURON (2017)

添加到收藏夹

Article Clinical Neurology

Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway

Chuan Qin et al.

STROKE (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

TREM2, Microglia, and Neurodegenerative Diseases

Felix L. Yeh et al.

TRENDS IN MOLECULAR MEDICINE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

Fargol Mazaheri et al.

EMBO REPORTS (2017)

添加到收藏夹

Review Immunology

Ontogeny and homeostasis of CNS myeloid cells

Marco Prinz et al.

NATURE IMMUNOLOGY (2017)

添加到收藏夹

Article Clinical Neurology

Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion

Bo-Ryoung Choi et al.

STROKE (2016)

添加到收藏夹

Article Cell Biology

Vps35-dependent recycling of Trem2 regulates microglial function

Jie Yin et al.

TRAFFIC (2016)

添加到收藏夹

Article Clinical Neurology

TREM2 regulates microglial cell activation in response to demyelination in vivo

Claudia Cantoni et al.

ACTA NEUROPATHOLOGICA (2015)

添加到收藏夹

Review Clinical Neurology

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

Heather M. Snyder et al.

ALZHEIMERS & DEMENTIA (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer's Disease Model

Yaming Wang et al.

CELL (2015)

添加到收藏夹

Article Clinical Neurology

Targeting miR-155 Restores Abnormal Microglia and Attenuates Disease in SOD1 Mice

Oleg Butovsky et al.

ANNALS OF NEUROLOGY (2015)

添加到收藏夹

Review Immunology

Microglia Development and Function

Debasis Nayak et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

添加到收藏夹

Article Immunology

TREM-2 Promotes Macrophage-Mediated Eradication of Pseudomonas aeruginosa via a PI3K/Akt Pathway

M. Zhu et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2014)

添加到收藏夹

Article Clinical Neurology

Cognitive Deterioration in Bilateral Asymptomatic Severe Carotid Stenosis

Laura Buratti et al.

STROKE (2014)

添加到收藏夹

Article Geriatrics & Gerontology

Insights into TREM2 biology by network analysis of human brain gene expression data

Paola Forabosco et al.

NEUROBIOLOGY OF AGING (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Attenuated Inflammatory Response in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Knock-Out Mice following Stroke

Matthias W. Sieber et al.

PLOS ONE (2013)

添加到收藏夹

Article Clinical Neurology

White matter changes contribute to corpus callosum atrophy in the elderly:: The LADIS study

C. Ryberg et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2008)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.