4.6 Review

Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Endocrinology & Metabolism

Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK

Xing Fu et al.

DIABETES (2016)

Article Endocrinology & Metabolism

Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes

Kei-ichi Ozaki et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2016)

Article Biochemistry & Molecular Biology

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia

Rachel J. Roth Flach et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Nutrition & Dietetics

Metabolic Inflammation-Differential Modulation by Dietary Constituents

Claire L. Lyons et al.

NUTRIENTS (2016)

Article Endocrinology & Metabolism

Effect of a p38 MAPK inhibitor on FFA-induced hepatic insulin resistance in vivo

S. Pereira et al.

NUTRITION & DIABETES (2016)

Article Cardiac & Cardiovascular Systems

Partial deletion of ROCK2 protects mice from high-fat diet-induced cardiac insulin resistance and contractile dysfunction

Hesham Soliman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)

Article Endocrinology & Metabolism

ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice

Greg H. Tesch et al.

DIABETES (2015)

Article Biochemistry & Molecular Biology

A high-fish-oil diet prevents adiposity and modulates white adipose tissue inflammation pathways in mice

Thereza Cristina Lonzetti Bargut et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Activated PKR inhibits pancreatic β-cell proliferation through sumoylation-dependent stabilization of P53

Ying Song et al.

MOLECULAR IMMUNOLOGY (2015)

Article Multidisciplinary Sciences

TAK1 inhibition prevents the development of autoimmune diabetes in NOD mice

Hui Cao et al.

SCIENTIFIC REPORTS (2015)

Article Endocrinology & Metabolism

ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance

Seung-Hwan Lee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)

Article Hematology

T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans

Tracey McLaughlin et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells

Darius Kang Lie Aw et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Review Immunology

Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases

H. Patterson et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2014)

Article Endocrinology & Metabolism

Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice

Takahisa Nakamura et al.

DIABETES (2014)

Article Endocrinology & Metabolism

Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice

Hongfeng Jiang et al.

DIABETOLOGIA (2014)

Article Medicine, General & Internal

Prevalence of Childhood and Adult Obesity in the United States, 2011-2012

Cynthia L. Ogden et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

Article Biochemistry & Molecular Biology

Role of Extracellular Signal- regulated Kinase 5 in Adipocyte Signaling*

Hong Zhu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Nutrition & Dietetics

Modulation of obesity-induced inflammation by dietary fats: mechanisms and clinical evidence

Kim-Tiu Teng et al.

NUTRITION JOURNAL (2014)

Article Multidisciplinary Sciences

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

Julia Szendroedi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Pharmacology & Pharmacy

Erk5 is a mediator toTGFβ1-induced loss of phenotype and function in human podocytes

Irbaz I. Badshah et al.

FRONTIERS IN PHARMACOLOGY (2014)

Review Immunology

Role of T cells in malnutrition and obesity

Valerie A. Gerriets et al.

FRONTIERS IN IMMUNOLOGY (2014)

Review Immunology

Inflammation, Cytokines and Insulin Resistance: A Clinical Perspective

Verena Wieser et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2013)

Article Medicine, Research & Experimental

AMPK, insulin resistance, and the metabolic syndrome

Neil B. Ruderman et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Biochemistry & Molecular Biology

An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice

Shannon M. Reilly et al.

NATURE MEDICINE (2013)

Article Multidisciplinary Sciences

Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKKβ

Tristan J. Iseli et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Brd2 Inhibits Adipogenesis via the ERK1/2 Signaling Pathway in 3T3-L1 Adipocytes

Kun Zang et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

Jason DeFuria et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance

Saul J. Priceman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

Myoung Sook Han et al.

SCIENCE (2013)

Article Pharmacology & Pharmacy

Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice

Yuan-Yuan Li et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)

Article Chemistry, Medicinal

Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators

Li-Fang Yu et al.

ACS MEDICINAL CHEMISTRY LETTERS (2013)

Review Biochemistry & Molecular Biology

MEK5/ERK5 pathway: The first fifteen years

Barbara A. Drew et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2012)

Review Cell Biology

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

Christopher K. Glass et al.

CELL METABOLISM (2012)

Review Cell Biology

NF-κB, the first quarter-century: remarkable progress and outstanding questions

Matthew S. Hayden et al.

GENES & DEVELOPMENT (2012)

Review Immunology

It takes two to tango: IκBs, the multifunctional partners of NF-κB

Michael Hinz et al.

IMMUNOLOGICAL REVIEWS (2012)

Article Biochemistry & Molecular Biology

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

Saswata Talukdar et al.

NATURE MEDICINE (2012)

Article Multidisciplinary Sciences

Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

Noritaka Kawasaki et al.

SCIENTIFIC REPORTS (2012)

Article Endocrinology & Metabolism

In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes

Kwang-Hoon Chun et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2011)

Article Biochemistry & Molecular Biology

Mechanism of lipid induced insulin resistance: Activated PKCε is a key regulator

Suman Dasgupta et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)

Article Medicine, Research & Experimental

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

Sandra Galic et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Biochemistry & Molecular Biology

p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis

Jaemin Lee et al.

NATURE MEDICINE (2011)

Article Multidisciplinary Sciences

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

Naoki Kumashiro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Cell Biology

Novel roles for JNK1 in metabolism

Bengt F. Belgardt et al.

AGING-US (2010)

Review Biochemistry & Molecular Biology

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

Goekhan S. Hotamisligil

Review Biochemistry & Molecular Biology

AMPK inhibition in health and disease

Benoit Viollet et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Kinetic Evidence for Unique Regulation of GLUT4 Trafficking by Insulin and AMP-activated Protein Kinase Activators in L6 Myotubes

Daniel J. Fazakerley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Endocrinology & Metabolism

AMPK as a mediator of hormonal signalling

Chung Thong Lim et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2010)

Article Endocrinology & Metabolism

Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate-treated obese mice

Daniela T. Furuya et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2010)

Review Biochemistry & Molecular Biology

cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance

Guadalupe Sabio et al.

TRENDS IN BIOCHEMICAL SCIENCES (2010)

Article Ophthalmology

Effects of p38 MAPK Inhibition on Early Stages of Diabetic Retinopathy and Sensory Nerve Function

Yunpeng Du et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)

Article Endocrinology & Metabolism

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

Hyun Woo Jeong et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)

Article Biochemistry & Molecular Biology

The Protein Kinase IKKε Regulates Energy Balance in Obese Mice

Shian-Huey Chiang et al.

Review Immunology

Mitogen activated protein kinases: a role in inflammatory bowel disease?

O. J. Broom et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2009)

Article Biochemistry & Molecular Biology

Targeted Disruption of ROCK1 Causes Insulin Resistance in Vivo

Dae Ho Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Pharmacology & Pharmacy

Overexpression of AMPKα1 Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats

Eunhui Seo et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2009)

Review Physiology

AMPK in Health and Disease

Gregory R. Steinberg et al.

PHYSIOLOGICAL REVIEWS (2009)

Article Biochemistry & Molecular Biology

Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity

Xiaoqing Zhang et al.

Article Gastroenterology & Hepatology

Epithelial: Lamina propria lymphocyte interactions promote epithelial cell differentiation

Stephanie Dahan et al.

GASTROENTEROLOGY (2008)

Article Endocrinology & Metabolism

Inflammation and endoplasmic reticulum stress in obesity and diabetes

G. S. Hotamisligil

INTERNATIONAL JOURNAL OF OBESITY (2008)

Article Biochemistry & Molecular Biology

Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells

Tao Pang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

Guadalupe Sabio et al.

SCIENCE (2008)

Review Biochemistry & Molecular Biology

Inflammation and insulin resistance

Carl de Luca et al.

FEBS LETTERS (2008)

Article Biochemistry & Molecular Biology

Protein kinase Cβ deficiency increases fatty acid oxidation and reduces fat storage

Rishipal R. Bansode et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Cell Biology

AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner

Yan Sun et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2007)

Article Endocrinology & Metabolism

Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo

Edward Park et al.

JOURNAL OF ENDOCRINOLOGY (2007)

Article Biochemistry & Molecular Biology

Metabolic stress signaling mediated by mixed-lineage kinases

Anja Jaeschke et al.

MOLECULAR CELL (2007)

Review Biochemistry & Molecular Biology

Atypical mitogen-activated protein kinases: Structure, regulation and functions

Phillipe Coulombe et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Article Medicine, Research & Experimental

Renal p38 MAP kinase activity in experimental diabetes

Radko Komers et al.

LABORATORY INVESTIGATION (2007)

Review Biochemistry & Molecular Biology

Differential regulation and properties of MAPKs

M. Raman et al.

ONCOGENE (2007)

Article Medicine, Research & Experimental

Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease

Varman T. Samuel et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Review Dentistry, Oral Surgery & Medicine

p38 pathway kinases as anti-inflammatory drug targets

J. F. Schindler et al.

JOURNAL OF DENTAL RESEARCH (2007)

Article Biochemistry & Molecular Biology

Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro

Milica Momcilovic et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Multidisciplinary Sciences

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

Gurol Tuncman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Medicine, Research & Experimental

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

Takashi Kadowaki et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Pharmacology & Pharmacy

Exercise and skeletal muscle glucose transporter 4 expression: Molecular mechanisms

SL McGee et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2006)

Article Endocrinology & Metabolism

Over-expression of AMP-activated protein kinase impairs pancreatic β-cell function in vivo

SK Richards et al.

JOURNAL OF ENDOCRINOLOGY (2005)

Article Multidisciplinary Sciences

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type 1 diabetes

A Jaeschke et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Endocrinology & Metabolism

Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin

PC Geiger et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2005)

Article Biochemistry & Molecular Biology

IKK-β links inflammation to obesity-induced insulin resistance

MC Arkan et al.

NATURE MEDICINE (2005)

Review Biochemistry & Molecular Biology

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

P Gual et al.

BIOCHIMIE (2005)

Article Biochemistry & Molecular Biology

IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

MCT Hu et al.

Article Biochemistry & Molecular Biology

Protein kinase C θ inhibits insulin signaling by phosphorylating IRS1 at Ser1101

Y Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

A novel IKKβ inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance

J Kamon et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Review Biochemistry & Molecular Biology

The AMP-activated protein kinase cascade - a unifying system for energy control

D Carling

TRENDS IN BIOCHEMICAL SCIENCES (2004)

Article Biochemistry & Molecular Biology

Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic β cells

D Arnette et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Endocrinology & Metabolism

Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance

SE Shoelson et al.

INTERNATIONAL JOURNAL OF OBESITY (2003)

Article Medicine, Research & Experimental

Obesity is associated with macrophage accumulation in adipose tissue

SP Weisberg et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Integrative & Complementary Medicine

Inhibitory effect of hypocrellin A on protein kinase C in liver and skeletal muscle of obese Zucker rats

XQ Qu et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2003)

Article Biochemistry & Molecular Biology

Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex

ZG Gao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

A central role for JNK in obesity and insulin resistance

J Hirosumi et al.

NATURE (2002)

Article Multidisciplinary Sciences

Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects

CP Regan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Physiology

Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle

SH Park et al.

JOURNAL OF APPLIED PHYSIOLOGY (2002)

Article Medicine, Research & Experimental

Role of AMP-activated protein kinase in mechanism of metformin action

GC Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

Article Biochemistry & Molecular Biology

Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y)

A Brunetti et al.

FASEB JOURNAL (2001)