期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 208, 期 1, 页码 23-32出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbiopara.2016.05.007
关键词
Parasitic nematodes; Parasitic helminths; Host-seeking behavior; Olfactory behavior; Skin-penetrating nematodes; Entomopathogenic nematodes
资金
- Whitcome Predoctoral Training Program, UCLA Molecular Biology Institute
- Ruth L. Kirschstein National Research Service Award [AI007323]
- National Science Foundation East Asia
- Pacific Summer Institute Fellowship [1414655]
- MacArthur Fellowship
- McKnight Scholar Award
- Searle Scholar Award
- Rita Allen Foundation
- NIH [1DP2DC014596]
The phylum Nematoda comprises a diverse group of roundworms that includes parasites of vertebrates, invertebrates, and plants. Human-parasitic nematodes infect more than one billion people worldwide and cause some of the most common neglected tropical diseases, particularly in low-resource countries [1]. Parasitic nematodes of livestock and crops result in billions of dollars in losses each year [1]. Many nematode infections are treatable with low-cost anthelmintic drugs, but repeated infections are common in endemic areas and drug resistance is a growing concern with increasing therapeutic and agricultural administration [1]. Many parasitic nematodes have an environmental infective larval stage that engages in host seeking, a process whereby the infective larvae use sensory cues to search for hosts. Host seeking is a complex behavior that involves multiple sensory modalities, including olfaction, gustation, thermosensation, and humidity sensation. As the initial step of the parasite-host interaction, host seeking could be a powerful target for preventative intervention. However, host-seeking behavior remains poorly understood. Here we review what is currently known about the host-seeking behaviors of different parasitic nematodes, including insect-parasitic nematodes, mammalian-parasitic nematodes, and plant-parasitic nematodes. We also discuss the neural bases of these behaviors. (C) 2016 Elsevier B.V. All rights reserved.
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