☆ 4.4 Review

Multifaceted nanolipidic carriers: a modish stratagem accentuating nose-to-brain drug delivery

JOURNAL OF NANOPARTICLE RESEARCH (2023)

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Review Nanoscience & Nanotechnology

Progresses in Nano-Enabled Platforms for the Treatment of Vaginal Disorders

Riya Patel et al.

Summary: Vaginal disorders, which are common ailments affecting the uterus, occur in approximately 50% to 60% of females. Conventional therapies often result in nonspecific targeting and dose-related side effects. However, site-specific and controlled delivery of therapeutics can enhance treatment efficacy, minimize systemic adverse effects, and overcome the limitations of traditional delivery systems.

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Off-Label use of Raloxifene hydrochloride in uterine fibroids: A novel insert-based formulation approach and IN-VIVO preclinical evaluation

Riya Patel et al.

Summary: Most uterine fibroids treatments are invasive, so using Raloxifene hydrochloride (RLH) as an off-label therapy for uterine fibroids is proposed. An RLH-loaded drug eluting insert (DEI) was formulated and its uterine-targeting efficiency after intrauterine administration was studied. The DEI showed no interference between the drug and excipients, and achieved desired drug release with degradation. Preclinical in vivo results demonstrated reduced size of uterine fibroids with RLH treatment, indicating successful uterine targeting via the vaginal route and potential for reducing side effects.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2023)

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Article Biochemical Research Methods

Formulation of Lipid-Based Nanocarriers of Lacidipine for Improvement of Oral Delivery: Box-Behnken Design Optimization, In Vitro, Ex Vivo, and Preclinical Assessment

Dheeraj Kataria et al.

Summary: The optimized nanostructured lipid carriers (NLCs) of the antihypertensive drug lacidipine (LAC) showed nanometric size, high entrapment efficiency, and drug loading, leading to significantly improved drug release and intestinal permeation, ultimately resulting in higher oral bioavailability and antihypertensive effect compared to LAC-dispersion.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2022)

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Article Engineering, Biomedical

Nanostructured-lipid carriers-Chitosan hydrogel beads carrier system for loading of resveratrol: A new method of topical application

Bi Wu et al.

Summary: This study developed nanostructured-lipid carriers encapsulated by Chitosan hydrogel beads for efficient topical delivery. The results showed that Chitosan hydrogel beads significantly improved the physical stability of the carriers and promoted drug release and skin permeation.

JOURNAL OF BIOMATERIALS APPLICATIONS (2022)

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Article Engineering, Biomedical

Design and evaluation of nanostructured lipid carriers loaded with Salvia officinalis extract for Alzheimer's disease treatment

Elena Markova et al.

Summary: This study aimed to design, develop, optimize, and characterize freeze-dried Salvia officinalis extract (FSE) loaded nanostructured lipid carriers (NLC) for intranasal administration. NLCs were prepared using a solvent evaporation method and optimized using central composite design (CCD). The optimized formulation showed spherical particles with a smooth exterior and a particle size ranging from 127 +/- 0.68 nm to 140 +/- 0.74 nm. The NLCs exhibited high drug loading and prolonged and controlled release. Protein adsorption studies indicated lower adsorption onto NLCp and higher adsorption onto NLCc surfaces. The modified ORAC assay demonstrated higher antioxidative activity for NLCo and NLCc compared to FSE. Cell culture tests suggested the potential of these NLCs for targeted drug delivery and controlled release in the brain.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2022)

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An Overview of Nanotechnologies for Drug Delivery to the Brain

Ahsan Ayub et al.

Summary: Drug delivery to the brain is a challenging task due to the blood-brain barrier. Nanomedicine, which combines nanotechnology, chemistry, and medicine, has shown promising results in improving drug delivery to the brain. Inorganic and organic nanoparticulate systems are being studied for this purpose.

PHARMACEUTICS (2022)

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Article Nanoscience & Nanotechnology

Formulation and Characterization of Febuxostat Loaded Nanostructured Lipid Carriers (NLCs)-Gel for Topical Treatment of Gout

Navni Sharma et al.

Summary: This study aimed to prepare and characterize Nano-Structured Lipid Carriers (NLCs) of Febuxostat (FB) incorporated in a gel for the treatment of Gout. The hot high-pressure homogenization technique was used to improve the physicochemical property of FB. Results showed that NLCs (1:3) had high entrapment and drug content, with 87% of the drug released in a controlled manner within 6 hours. This indicates that the NLCs gel formulation can modify drug release, increase bioavailability, and reduce side effects.

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Review Pharmacology & Pharmacy

Nanostructured Lipid Carriers for Nose to Brain Delivery Targeting CNS: Diversified Role of Liquid Lipids for Synergistic Action

Avinash Ramrao Tekade et al.

Summary: Neurological disorders such as Alzheimer's disease and Parkinson's disease are increasingly affecting the elderly population. The conventional route of administration faces the challenge of the blood brain and blood-cerebrospinal fluid barriers. Intranasal delivery is considered a promising alternative. Nanostructured lipid carriers, particularly second generation carriers, offer advantages in terms of stability, scalability, and drug targeting. This review explores the synergistic actions of oils/liquid lipids with synthetic drugs for therapeutic benefits.

ADVANCED PHARMACEUTICAL BULLETIN (2022)

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Article Instruments & Instrumentation

Nanostructured lipid carriers of isradipine for effective management of hypertension and isoproterenol induced myocardial infarction

Tausif Alam et al.

Summary: The study successfully improved the oral bioavailability of isradipine through optimizing the formulation of nanostructured lipid carriers, presenting a promising strategy for long-term management of hypertension. Additionally, the nanostructured lipid carrier of isradipine demonstrated effective cardioprotection in a rat model of myocardial infarction.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Article Instruments & Instrumentation

Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical delivery: QbD-driven design, optimization, and in vitro and ex vivo evaluations

Arisha Mahmood et al.

Summary: This study focused on QbD-based design and development of luliconazole-loaded nanostructured lipid carriers (NLCs) hydrogel for improved skin retention and permeation. Optimized formulation exhibited desirable characteristics and sustained release up to 42 hours. Dermatokinetics assessment revealed higher drug concentration in epidermis and dermis with the designed NLCs gel compared to the marketed cream, suggesting it as a promising formulation for enhanced antifungal activity.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Article Pharmacology & Pharmacy

Anti-oxidant Containing Nanostructured Lipid Carriers of Ritonavir: Development, Optimization, and In Vitro and In Vivo Evaluations

Srinivas Reddy Jitta et al.

Summary: This study aimed to develop nanostructured lipid carriers (NLCs) encapsulating ritonavir to reduce its side effects and enhance oral bioavailability. By optimizing the preparation method and drug release characteristics, significant improvements in pharmacokinetics were observed.

AAPS PHARMSCITECH (2022)

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Article Pharmacology & Pharmacy

Nanostructured lipid carriers loaded with an association of minoxidil and latanoprost for targeted topical therapy of alopecia

Paula M. M. Oliveira et al.

Summary: This study aimed to develop a safe formulation based on nanostructured lipid carriers (NLC) that can deliver minoxidil and latanoprost to the hair follicles. The results showed that the NLC effectively encapsulated the drugs, penetrated into the hair follicles, and demonstrated good tolerance.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Thermosensitive in situ hydrogels of rivastigmine-loaded lipid-based nanosystems for nose-to-brain delivery: characterisation, biocompatibility, and drug deposition studies

S. Cunha et al.

Summary: Acetylcholinesterase inhibitors are commonly used drugs for managing Alzheimer's disease, but they have low bioavailability in the brain. This study tested in situ thermosensitive nasal gels containing nanostructured lipid carriers for the direct delivery of an acetylcholinesterase inhibitor to the brain. The results suggest that this approach has the potential to improve the nose-to-brain delivery of the drug.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Thermoresponsive in situ gel of curcumin loaded solid lipid nanoparticle: Design, optimization and in vitro characterization

Mukta Agrawal et al.

Summary: Curcumin has been shown to have antioxidant, anti-inflammatory, amyloid inhibition, and neuroprotective properties, but its poor solubility, lipophilicity, rapid metabolism, and short half-life limit its efficacy in treating AD. This study developed curcumin-loaded solid lipid nanoparticles (CSL) to improve the physicochemical properties and achieved prolonged release. However, the loading reduced the antioxidant potency of curcumin.

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Quality by design (QbD)-based fabrication of atazanavir-loaded nanostructured lipid carriers for lymph targeting: bioavailability enhancement using chylomicron flow block model and toxicity studies

Vishal C. Gurumukhi et al.

Summary: Atazanavir-loaded nanostructured lipid carriers (NLCs) were successfully fabricated using a quality by design (QbD) approach to improve bioavailability and safety after oral administration. Critical material attributes (CMAs) and critical process parameters (CPP) such as lipid concentrations, surfactant concentrations, and pressure of high-pressure homogenizer were identified. The formulation variables were optimized through statistical analysis to achieve the desired NLCs with enhanced drug release characteristics.

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Topical nanostructured lipid carriers of alpha-mangostin and resveratrol for synergistic antioxidant activity

Wipada Samprasit et al.

Pharmaceutical Nanotechnology (2022)

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Formulation and Characterization of Nanostructured Lipid Carriers of Rizatriptan Benzoate-Loaded In Situ Nasal Gel for Brain Targeting

Dyandevi Mathure et al.

Summary: The intranasal route is effective in improving drug absorption and targeting the brain for treatment of central nervous diseases. This study successfully developed an in situ nasal gel containing rizatriptan benzoate-loaded nanostructured lipid carriers, which showed potential for efficient brain targeting based on pharmacokinetic and nose-to-brain targeting parameter studies.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2022)

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Article Pharmacology & Pharmacy

Hyaluronic acid coated teriflunomide (A771726) loaded lipid carriers for the oral management of rheumatoid arthritis

Mariam Zewail et al.

Summary: In this study, hyaluronic acid-coated teriflunomide-loaded nanostructured lipid carriers were developed for targeted treatment of inflamed rheumatic joints. The formulation showed good stability and sustained release in vitro. Cell culture studies and in vivo experiments demonstrated that the hyaluronic acid-coated teriflunomide-loaded nanostructured lipid carriers improved drug bioavailability, reduced inflammation levels, and promoted joint healing.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Combinatorial delivery of Ribociclib and green tea extract mediated nanostructured lipid carrier for oral delivery for the treatment of breast cancer synchronising in silico, in vitro, and in vivo studies

Ali Sartaj et al.

Summary: This research investigated the potential of dual drug-loaded nanostructure lipidic carriers (NLCs) of green tea extract and Ribociclib in the treatment of breast cancer. In vitro and in vivo studies were conducted to evaluate the drug release, bioavailability, and therapeutic efficacy of the prepared NLCs. The results demonstrated controlled drug release, increased bioavailability, and promising therapeutic potential.

JOURNAL OF DRUG TARGETING (2022)

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Article Pharmacology & Pharmacy

Meropenem-Loaded Nanostructured Lipid Carriers For Skin and Soft Tissue Infection Caused by Staphylococcus aureus: Formulation, Design, and Evaluation

Kshipra Rajpoot et al.

Summary: Aim Meropenem hydrochloride (MpM)-loaded nanostructured lipid carriers were designed for the effective management of skin infection caused by Staphylococcus aureus via topical route. The study confirmed the potential and stability of the NLCs as a vehicle for sustained topical drug delivery through pharmacodynamic studies, fluorescence microscopy, and in vitro release studies. The MpM-NLC gel, with enhanced adhesion and sustained release properties, showed significant inhibition effects against Staphylococcus aureus.

AAPS PHARMSCITECH (2022)

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Article Pharmacology & Pharmacy

Quetiapine Fumarate Loaded Nanostructured Lipid Carrier for Enhancing Oral Bioavailability: Design, Development and Pharmacokinetic Assessment

Shweta Agarwal et al.

Summary: The study aimed to enhance the bioavailability of Quetiapine Fumarate by developing Nanostructured Lipid Carriers through Design of Experiment. The optimized formulation showed high Entrapment Efficiency and small Particle Size, leading to a significant enhancement in bioavailability. The results demonstrated the potential of Nanostructured Lipid Carriers as a promising delivery system for improving the oral bioavailability of Quetiapine Fumarate.

CURRENT DRUG DELIVERY (2021)

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Article Biophysics

QbD-Steered Development of Biotin-Conjugated Nanostructured Lipid Carriers for Oral Delivery of Chrysin: Role of Surface Modification for Improving Biopharmaceutical Performance

Teenu Sharma et al.

Summary: Bioactives show diverse pharmacological activities, but their low and inconsistent bioavailability hinders their therapeutic potential. Development of nanostructured lipid carriers for chrysin demonstrated improved drug absorption and cellular uptake efficiency, highlighting the high potential of Bio-NLCs for enhanced biopharmaceutical performance.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Pharmacology & Pharmacy

Nanostructured lipid carrier-incorporated gel for efficient topical delivery of fluconazole

Archana Patil et al.

Summary: In this study, nanostructured lipid carriers (NLCs) of fluconazole were prepared to enhance drug permeability for effective topical drug delivery. The optimized F-2 NLC formulation showed better activities in ex vivo and in vitro studies compared to marketed gel.

THERAPEUTIC DELIVERY (2021)

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Review Nanoscience & Nanotechnology

Nanostructured Lipid Carriers- A Versatile Carrier for Oral Delivery of Lipophilic Drugs

Priyanshi Patel et al.

Summary: This article explores the potential and applications of lipid nanoparticles in enhancing oral bioavailability. They increase drug absorption, improve bioavailability, and are considered safe. Nanostructured Lipid Carriers (NLCs) are a type of lipid nanoparticles that can overcome the limitations of traditional lipid nanoparticles.

RECENT PATENTS ON NANOTECHNOLOGY (2021)

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Article Biophysics

Nanostructured lipid carriers for hair follicle-targeted delivery of clindamycin and rifampicin to hidradenitis suppurativa treatment

Maira N. Pereira et al.

Summary: The study proposes a novel topical treatment using nano structured lipid carriers (NLC) entraping an association of clindamycin phosphate (CDM) and rifampicin (RIF) for the management of hidradenitis suppurativa. The formulation showed high drug entrapment efficiencies and safety in various assays, with NLC demonstrating affinity for lipidic domains of the stratum corneum, potentially benefiting the targeting of sebaceous units. In vitro experiments indicated promising results with NLC accumulating in hair follicles openings while significantly increasing the uptake of RIF, suggesting its potential as a strategy for the topical treatment of infections affecting the pilosebaceous units.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Dermatology

Preparation and evaluation of adapalene nanostructured lipid carriers for targeted drug delivery in acne

Saman Ahmad Nasrollahi et al.

Summary: The study focused on the efficacy of 0.1% ADA-loaded nanostructured lipid carriers in treating acne, showing significant improvement in acne severity index after 12 weeks of treatment.

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Article Chemistry, Medicinal

Development and machine-learning optimization of mucoadhesive nanostructured lipid carriers loaded with fluconazole for treatment of oral candidiasis

Mohammed H. Elkomy et al.

Summary: This study successfully prepared and optimized mucoadhesive nanostructured lipid carrier (NLC) impregnated with fluconazole for better management of oral candidiasis. The optimized nanoparticles exhibited small particle size, high entrapment efficiency, sustained release, and high inhibition efficiency against Candida albicans.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2021)

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Article Biochemistry & Molecular Biology

Nose-to-brain delivery of teriflunomide-loaded lipid-based carbopol-gellan gum nanogel for glioma: Pharmacological and in vitro cytotoxicity studies

Dnyandev Gadhave et al.

Summary: The study successfully developed a novel nano lipid-based carbopol-gellan gum in situ gel for the safe delivery of teriflunomide in glioma patients. The formulation showed promising permeability enhancement and significant therapeutic efficacy.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Design and dermatokinetic evaluation of Apremilast loaded nanostructured lipid carriers embedded gel for topical delivery: A potential approach for improved permeation and prolong skin deposition

Vamshi Krishna Rapalli et al.

Summary: The study successfully developed Apremilast-loaded nanostructured lipid carriers with good encapsulation efficiency and controlled release properties, showing significant improvement in psoriasis efficacy through various studies.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Development, in vitro and in vivo evaluation of miltefosine loaded nanostructured lipid carriers for the treatment of Cutaneous Leishmaniasis

Anam Sajjad Khan et al.

Summary: The study aimed to enhance the efficacy and reduce the toxic effects of MTF in treating leishmaniasis by loading it into NLCs. The optimized NLCs showed good drug release, significantly increased anti-leishmanial efficacy, and better safety profile compared to MTF solution. The passive targeting ability of MTF-loaded NLCs was confirmed through macrophage uptake study.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Biotechnology & Applied Microbiology

A promising and effective platform for delivering hydrophilic depigmenting agents in the treatment of cutaneous hyperpigmentation: kojic acid nanostructured lipid carrier

Khadijeh Khezri et al.

Summary: This study successfully prepared and characterised kojic acid nanostructured lipid carriers (KA-NLCs), with the optimized formulation KA-NLC3 showing stable drug release and enhanced percutaneous delivery for cosmetic applications.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Nanostructured Lipid Carriers for Intranasal Administration of Olanza-pine in the Management of Schizophrenia

Sarbjot Kaur et al.

Summary: The study focused on the preparation and evaluation of olanzapine loaded NLC for the treatment of schizophrenia via intranasal route. The results revealed the potential application of novel olanzapine-NLC in intranasal drug delivery system. The optimized NLC demonstrated good encapsulation efficiency and release rate, indicating its effectiveness in drug delivery for schizophrenia.

CURRENT MOLECULAR PHARMACOLOGY (2021)

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Preparation, characterization, and in vivo evaluation of perphenazine-loaded nanostructured lipid carriers for oral bioavailability improvement

Zahra Saghafi et al.

Summary: The study focused on improving the bioavailability of perphenazine (PPZ) by incorporating it into nanostructured lipid carriers (NLCs). The optimized NLCs showed good stability, appropriate size, high EE, extended-release properties, and enhanced oral bioavailability. NLCs proved to be an effective nanocarrier for oral delivery of PPZ.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2021)

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Article Pharmacology & Pharmacy

Exploration of bromelain laden nanostructured lipid carriers: An oral platform for bromelain delivery in rheumatoid arthritis management

Manu Sharma et al.

Summary: The study prepared Br-NCs with high drug loading, stability, and efficacy in rheumatoid arthritis management. The optimized batch showed good stability in gastric environment, sustained release behavior, and significantly prolonged shelf-life compared to bromelain. Animal experiments demonstrated the remarkable therapeutic effects of Br-NCs in alleviating arthritis symptoms and preserving joint integrity.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Nanosuspension for oral delivery of tadalafil: Pharmacodynamic and pharmacokinetic studies

Amit A. Patel et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Instruments & Instrumentation

Intranasal drug delivery for treatment of Alzheimer's disease

Leonor C. Fonseca et al.

Summary: Alzheimer's disease is a neurodegenerative condition with severe consequences on patient quality of life. The intranasal route is suggested as a promising alternative for improving treatment of Alzheimer's disease, but there is currently no clear alternative delivery system in the market with advantageous bioavailability and safety.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Review Pharmacology & Pharmacy

Recent advances in nano delivery systems for blood-brain barrier (BBB) penetration and targeting of brain tumors

Shriya Reddy et al.

Summary: Gliomas, making up about 80% of brain tumors, have a low survival rate and limited treatment options. Challenges in developing delivery systems to cross the blood-brain barrier and blood-tumor barrier are highlighted, along with descriptions of targeted nanodelivery systems showing potential for success. Recent studies on nanoparticles for brain delivery over the past five years are discussed, as well as insights into clinical trials assessing the efficacy of these nanodelivery systems for gliomas.

DRUG DISCOVERY TODAY (2021)

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Article Chemistry, Multidisciplinary

The Bio-Persistence of Reversible Inflammatory, Histological Changes and Metabolic Profile Alterations in Rat Livers after Silver/Gold Nanorod Administration

Ying Liu et al.

Summary: The study found that after injection of Au@AgNRs into rats, silver was rapidly cleared from blood and mainly accumulated in the liver and spleen until 8 weeks. Detected parameters showed a two-stage response to Au@AgNRs administration, with significant changes in toxicological parameters in the short term (2 weeks) but mostly returning to normal levels after a 6-week recovery.

NANOMATERIALS (2021)

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Article Pharmacology & Pharmacy

Enhanced oral bioavailability of nintedanib esylate with nanostructured lipid carriers by lymphatic targeting: In vitro, cell line and in vivo evaluation

Priyanshi Patel et al.

Summary: The research successfully developed NE-NLCs, which improved the oral bioavailability of NE via lymphatic uptake. Experiment results showed that NE-NLCs exhibited good performance in drug release, tissue distribution, cellular uptake, and cytotoxicity.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Pharmacology & Pharmacy

Gamma sterilization and in vivo evaluation of cationic nanostructured lipid carriers as potential ocular delivery systems for antiglaucoma drugs

John Youshia et al.

Summary: Solid lipid nanoparticles and nanostructured lipid carriers have shown potential in improving ocular bioavailability of drugs with poor corneal permeability. Gamma radiation was found to be superior to autoclaving in preserving the properties of lipid nanoparticles, demonstrating it as a viable alternative for sterilization. Additionally, nanostructured lipid carriers enhance the pharmacological response of topically administered methazolamide for treating glaucoma.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Nanoscience & Nanotechnology

Development of Inhalable Nanostructured Lipid Carriers for Ciprofloxacin for Noncystic Fibrosis Bronchiectasis Treatment

Alanood S. Almurshedi et al.

Summary: This study developed optimized inhalable nanostructured lipid carriers (NLCs) for CIP to enhance deposition and accumulation in deeper parts of the lungs for treatment of noncystic fibrosis bronchiectasis (NCFB). The results showed that CIP-NLCs were in the nanometric size range, had efficient CIP encapsulation, and NCMPs prepared by spray-drying with different ratios of chitosan exhibited different properties.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Pharmacology & Pharmacy

Fabrication, characterization and optimization of nanostructured lipid carrier formulations using Beclomethasone dipropionate for pulmonary drug delivery via medical nebulizers

Iftikhar Khan et al.

Summary: This study aimed to develop and optimize NLC formulations in combination with various medical nebulizers and airflow rates for superior aerosolization performance. The results showed that the F10 formulation combined with the Air jet nebulizer exhibited the best performance in terms of particle size and drug deposition, making it the most suitable combination for delivering BDP-NLC formulations.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Appraisal of Nano-lipidic Astaxanthin Cum Thermoreversible Gel and its Efficacy in Haloperidol Induced Parkinsonism

Deepika Gautam et al.

Summary: This study formulated astaxanthin-laden nanostructured lipid carriers for better neuronal uptake and efficacy in Parkinsonism. In-vivo results demonstrated improved behavior in animals treated with astaxanthin in-situ gel, suggesting its potential as an adjuvant therapy for the disease. Pharmacokinetic studies showed better availability of astaxanthin in the brain with the formulated gel compared to conventional gel.

CURRENT DRUG DELIVERY (2021)

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Article Medicine, Research & Experimental

Design and optimization of curcumin loaded nano lipid carrier system using Box-Behnken design

Mukta Agrawal et al.

Summary: This study successfully optimized the formulation of curcumin-loaded nanolipid carrier with good stability and higher drug entrapment, which is in an acceptable size range for brain delivery.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Chemistry, Physical

Polymer-coated silver-iron nanoparticles as efficient and biodegradable MRI contrast agents

Vincenzo Amendola et al.

Summary: Bimetallic nanoparticles, such as the silver-iron nanoparticles coated with polyethylene glycol discussed in this study, exhibit unique properties and excellent performance in terms of relaxivity, stability, and biocompatibility. The one-step, low-cost synthesis method and biodegradation capability of these nanoparticles make them promising for biomedical applications, addressing issues commonly encountered in nanoparticulate contrast agents.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Preparation and Evaluation of Nanostructured Lipid Carrier for Topical Delivery of Velutin: Synthetic Tyrosinase Inhibitor

Se Hyeop Cheon et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2021)

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Review Pharmacology & Pharmacy

In Vitro Evaluation of Nasal Aerosol Depositions: An Insight for Direct Nose to Brain Drug Delivery

Aida Maaz et al.

Summary: The nasal cavity is a promising route for drug delivery to the brain, with the potential to bypass the blood-brain barrier. However, challenges exist in depositing drug molecules in the olfactory region due to its limited surface area. Aerosolized particles have the potential to target the olfactory region, but specific deposition within this area is influenced by various factors such as formulation properties, delivery device, and patient physiology.

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Article Pharmacology & Pharmacy

Bergamot oil as an integral component of nanostructured lipid carriers and a photosensitizer for photodynamic treatment of vitiligo: Characterization and clinical experimentation

Mai Shaaban et al.

Summary: The study demonstrated the potential of BO-containing NLCs for PDT of vitiligo, showing promising results in preclinical and clinical trials.

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Preparation of Ergosterol-Loaded Nanostructured Lipid Carriers for Enhancing Oral Bioavailability and Antidiabetic Nephropathy Effects

Zhonghua Doug et al.

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Development and evaluation of a film-forming system hybridized with econazole-loaded nanostructured lipid carriers for enhanced antifungal activity against dermatophytes

Young-Guk Na et al.

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Development of folic acid-loaded nanostructured lipid carriers for topical delivery: preparation, characterisation and ex vivo investigation

Hussein Osman Ammar et al.

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Optimization of nanostructured lipid carriers: understanding the types, designs, and parameters in the process of formulations

Bavani Subramaniam et al.

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Coated Lipidic Nanoparticles as a New Strategy for Enhancing Nose -to -Brain Delivery of a Hydrophilic Drug Molecule

Lamis H. Salem et al.

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Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review

Mohamed Haider et al.

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Article Chemistry, Medicinal

Systematic development and characterization of curcumin-loaded nanogel for topical application

Payal Kesharwani et al.

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Intranasal delivery of topiramate nanoemulsion: Pharmacodynamic, pharmacokinetic and brain uptake studies

Ravish J. Patel et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

Nanostructured lipid carriers as oral delivery systems for improving oral bioavailability of nintedanib by promoting intestinal absorption

Yunjing Zhu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

Nose-to-brain delivery of sumatriptan-loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation

Moein Masjedi et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2020)

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Article Pharmacology & Pharmacy

Curcumin loaded nanostructured lipid carriers for enhanced skin retained topical delivery: optimization, scale-up, in-vitro characterization and assessment of ex-vivo skin deposition

Vamshi Krishna Rapalli et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Article Biophysics

Chitosan-coated nanostructured lipid carriers of fenofibrate with enhanced oral bioavailability and efficacy

Yong-Chul Pyo et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Pharmacology & Pharmacy

Development and Evaluation of Astaxanthin as Nanostructure Lipid Carriers in Topical Delivery

Qiang Geng et al.

AAPS PHARMSCITECH (2020)

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Review Pharmacology & Pharmacy

Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery

Iti Chauhan et al.

ADVANCED PHARMACEUTICAL BULLETIN (2020)

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Article Chemistry, Medicinal

Nanostructured lipid carriers engineered for intranasal delivery of teriflunomide in multiple sclerosis: optimization and in vivo studies

Dnyandev G. Gadhave et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2019)

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Article Chemistry, Medicinal

Formulation and optimization of intranasal nanolipid carriers of pioglitazone for the repurposing in Alzheimer's disease using Box-Behnken design

Gifty M. Jojo et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2019)

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Article Biophysics

Development of nose-to-brain delivery of ketoconazole by nanostructured lipid carriers against cryptococcal meningoencephalitis in mice

Wei Du et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Pharmacology & Pharmacy

Agranulocytosis-Protective Olanzapine-Loaded Nanostructured Lipid Carriers Engineered for CNS Delivery: Optimization and Hematological Toxicity Studies

Dnyandev G. Gadhave et al.

AAPS PHARMSCITECH (2019)

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Article Chemistry, Multidisciplinary

PEGylated rhenium nanoclusters: a degradable metal photothermal nanoagent for cancer therapy

Zhaohua Miao et al.

CHEMICAL SCIENCE (2019)

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Review Medicine, Research & Experimental

Nanostructured lipid carriers for site-specific drug delivery

Archana Khosa et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Pharmacology & Pharmacy

Peyer'e patch targeting of Isradipine loaded Solid Lipid Nanoparticles: It's cellular uptake study

Jagruti B. Prajapati et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2018)

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Review Pharmacology & Pharmacy

Nanomedicine for Intranasal Delivery to Improve Brain Uptake

Amit A. Patel et al.

CURRENT DRUG DELIVERY (2018)

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Review Nanoscience & Nanotechnology

Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors

Fakhar Ud Din et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Chemistry, Medicinal

Nose to Brain Delivery of Rivastigmine by In Situ Gelling Cationic Nanostructured Lipid Carriers: Enhanced Brain Distribution and Pharmacodynamics

Preeti Wavikar et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Article Toxicology

Biopersistence and translocation to extrapulmonary organs of titanium dioxide nanoparticles after subacute inhalation exposure to aerosol in adult and elderly rats

Laurent Gate et al.

TOXICOLOGY LETTERS (2017)

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Review Chemistry, Multidisciplinary

A Review of the Structure, Preparation, and Application of NLCs, PNPs, and PLNs

Qianwen Li et al.

NANOMATERIALS (2017)

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Article Pharmacology & Pharmacy

Pulmonary targeting potential of rosuvastatin loaded nanostructured lipid carrier: Optimization by factorial design

Arpana Patil-Gadhe et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

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Article Nanoscience & Nanotechnology

Intranasal Administration of Chitosan-Coated Nanostructured Lipid Carriers Loaded with GDNF Improves Behavioral and Histological Recovery in a Partial Lesion Model of Parkinson's Disease

O. Gartziandia et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2016)

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Article Pharmacology & Pharmacy

Nanoemulsions for Intranasal Delivery of Riluzole to Improve Brain Bioavailability: Formulation Development and Pharmacokinetic Studies

Rajesh H. Parikh et al.

CURRENT DRUG DELIVERY (2016)

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Review Medicine, Research & Experimental

Nanostructured lipid carriers: versatile oral delivery vehicle

Neelam Poonia et al.

FUTURE SCIENCE OA (2016)

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Article Biophysics

Chitosan coated nanostructured lipid carriers for brain delivery of proteins by intranasal administration

Oihane Gartziandia et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2015)

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Article Pharmacology & Pharmacy

Optimization of artemether-loaded NLC for intranasal delivery using central composite design

Kunal Jain et al.

DRUG DELIVERY (2015)

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Article Pharmacology & Pharmacy

Optimization of nanostructured lipid carriers of lamotrigine for brain delivery: in vitro characterization and in vivo efficacy in epilepsy

Tausif Alam et al.

EXPERT OPINION ON DRUG DELIVERY (2015)

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Article Biochemistry & Molecular Biology

Rivastigmine-loaded in situ gelling nanostructured lipid carriers for nose to brain delivery

Preeti R. Wavikar et al.

JOURNAL OF LIPOSOME RESEARCH (2015)

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Article Biophysics

Surface engineered nanostructured lipid carriers for efficient nose to brain delivery of ondansetron HCl using Delonix regia gum as a natural mucoadhesive polymer

Tejas B. Devkar et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

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Article Pharmacology & Pharmacy

Montelukast-loaded nanostructured lipid carriers: Part II Pulmonary drug delivery and in vitro-in vivo aerosol performance

Arpana Patil-Gadhe et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)

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Article Pharmacology & Pharmacy

Pharmacoscintigraphic evaluation of potential of lipid nanocarriers for nose-to-brain delivery of antidepressant drug

M. Intakhab Alam et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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Article Pharmacology & Pharmacy

Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route

Yasmine M. Gabal et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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Article Pharmacology & Pharmacy

Intranasal infusion of nanostructured lipid carriers (NLC) containing CNS acting drug and estimation in brain and blood

M. Intakhab Alam et al.

DRUG DELIVERY (2013)

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Review Pharmacology & Pharmacy

Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood-brain barrier: an excellent platform for brain targeting

Chandrakantsing Vijaysing Pardeshi et al.

EXPERT OPINION ON DRUG DELIVERY (2013)

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Article Pharmacology & Pharmacy

Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs): Development, characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs?

Surajit Das et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2012)

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Article Pharmacology & Pharmacy

Development of an Itraconazole-loaded nanostructured lipid carrier (NLC) formulation for pulmonary application

J. Pardeike et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

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Review Neurosciences

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

Berislav V. Zlokovic

NATURE REVIEWS NEUROSCIENCE (2011)

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