Synthesis, spectral studies, DFT, biological evaluation, molecular docking and dyeing performance of 1-(4-((2-amino-5-methoxy)diazenyl)phenyl) ethanone complexes with some metallic ions

Four Co(II), (C1); Ni(II), (C2); Cu(II), (C3) and Zn(II), (C4) chelates have been synthesized with 1-(4-((2-amino-5-methoxy)diazenyl)phenyl)ethanone ligand (L). The produced compounds have been identified by using spectral studies, elemental analysis (C.H.N.O), conductivity and magnetic properties. The produced metal che-lates were studied using molar ratio as well as sequences contrast types. Rate of concentration (1 x10-4 -3 x10-4 Mol/L) sequence Beer's law. Compound solutions have been noticed height molar absorptivity. The free of ligand and metal chelates had been applied as disperse dyes on cotton fabrics. Furthermore, the antibacterial activity of the produced compounds against various bacteria had been investigated. For the gained datum, a tetrahedral geometrical structure has been suggested for each primed complex. Molecular docking investigation was carried out to ascertain the inhibitory action of the studied compounds against 1HNJ protein, the target enzyme for the antimicrobial agents. The findings showed that, when compared to other compounds, (C1) has the highest binding affinity. Therefore, these molecules might make good candidates for antimicrobials. The quantum chemical parameters are calculated, and the molecular structure complexes were theoretically optimized.

Automated summary

Four Co(II), Ni(II), Cu(II), and Zn(II) chelates were synthesized using the ligand 1-(4-((2-amino-5-methoxy)diazenyl)phenyl)ethanone. The compounds were characterized using spectral studies, elemental analysis, conductivity, and magnetic properties. The metal chelates were applied as disperse dyes on cotton fabrics and showed antibacterial activity. Molecular docking investigation revealed that C1 had the highest binding affinity against the target enzyme, making it a potential antimicrobial candidate.