☆ 4.6 Article

Antileishmanial activities of three chalcone derivatives and their association with plasma membrane rigidity as assessed by EPR spectroscopy

JOURNAL OF MOLECULAR STRUCTURE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer

Amr Ahmed WalyEldeen et al.

Summary: There is an urgent need for innovative anticancer treatments that are highly effective and have low toxicity due to the development of drug resistant malignancies and the lack of specificity in current treatments. Chalcones, which are the precursors for flavonoids and isoflavonoids, are readily available and have simple chemical structures, allowing for the synthesis of several chalcone derivatives. Both naturally occurring and synthetic chalcone derivatives have shown promising biological activities against various cancer hallmarks, and this review will discuss their mechanisms of action in detail.

CHEMICO-BIOLOGICAL INTERACTIONS (2023)

添加到收藏夹

Article Chemistry, Physical

Antileishmanial activity of 3,4,5-trisubstituted isoxazoles by interaction with Leishmania amazonensis plasma membrane

Lais Alonso et al.

Summary: The isoxazole core is essential in discovering new and potent leishmanicidal agents. In this study, 35 3,4,5-trisubstituted isoxazole derivatives were tested against L. amazonensis, with 8 compounds showing potent antileishmanial activity, particularly compounds 2e and 3de which also exhibited low toxicity for mammalian cells.

JOURNAL OF MOLECULAR STRUCTURE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ivermectin and curcumin cause plasma membrane rigidity in Leishmania amazonensis due to oxidative stress

Lais Alonso et al.

Summary: Spin label electron paramagnetic resonance (EPR) spectroscopy was used to study the mechanisms of action of ivermectin and curcumin against Leishmania (L.) amazonensis promastigotes. Both compounds were found to result in increased plasma membrane rigidity due to oxidative processes. Ivermectin showed higher activity at low cell concentrations, but no significant difference was observed at concentrations greater than 1.5 x 108 parasites/mL.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Membrane dynamics in Leishmania amazonensis and antileishmanial activities of β-carboline derivatives

Lais Alonso et al.

Summary: The beta-carboline compounds 8i and 6d showed antileishmanial activity and selectivity, with lower affinity for the parasite membrane. These compounds caused membrane rigidity in Leishmania promastigotes, leading to modifications in cell structure and reduced parasite numbers in infected macrophages. Moreover, they exhibited greater toxicity towards the protozoa than macrophages, inducing various cellular changes and alterations in the cell cycle.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents

Andreza R. Garcia et al.

Summary: This study evaluated 36 chalcone derivatives as potential inhibitors of Leishmania infantum arginase (LiARG), with seven compounds showing significant inhibition effects. Some compounds exhibited good activity against L. infantum parasites and higher selectivity towards parasites than host cells, indicating potential therapeutic applications.

FRONTIERS IN CHEMISTRY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Comparative EPR spectroscopy analysis of amphotericin B and miltefosine interactions with Leishmania, erythrocyte and macrophage membranes

Lais Alonso et al.

Summary: The study using EPR spectroscopy investigated the interactions of AmB and MIL with cell membranes of various cells, revealing higher affinity of AmB for Leishmania parasites and a more localized effect on the membrane. This suggests that the antiproliferative and cytotoxic effects of these drugs are associated with changes in cell membranes.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Interaction of 4′-methylflavonoids with biological membranes, liposomes, and human albumin

Aleksandra Wloch et al.

Summary: The study aimed to compare the effects of three synthesized chemical compounds derived from methylated flavonoids on red blood cell membranes, phosphatidylcholine model membranes, and human serum albumin. The compounds were found to be non-toxic and to influence the hydrophilic and hydrophobic regions of membranes, with different compounds having varying impacts depending on the membrane type. The compounds also bind with human serum albumin through a process of static quenching, involving hydrogen bonding interactions and van der Waals forces.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Review Oncology

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Radka Michalkova et al.

Summary: Despite significant progress in cancer treatment, mortality rates for some types of cancer have not decreased significantly, leading to a focus on finding novel anticancer drugs. Chalcones, precursors of flavonoid synthesis in plants, are natural compounds with pleiotropic biological effects, including anticancer properties.

CANCERS (2021)

添加到收藏夹

Review Infectious Diseases

A Review of Leishmaniasis: Current Knowledge and Future Directions

Sarah Mann et al.

Summary: This review summarizes the current knowledge of cutaneous, mucosal, and visceral leishmaniasis in terms of epidemiology, clinical manifestations, diagnosis, and treatment. The article also discusses newer tests, vaccine candidates, and updated treatment recommendations for leishmaniasis. Understanding the prominent clinical manifestations and major parasite species can help guide recommendations for diagnosis and treatment of this complex disease.

CURRENT TROPICAL MEDICINE REPORTS (2021)

添加到收藏夹

Review Chemistry, Medicinal

Chalcone hybrids and their antimalarial activity

Peng Cheng et al.

ARCHIV DER PHARMAZIE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Dietary Compound Isoliquiritigenin, an Antioxidant from Licorice, Suppresses Triple-Negative Breast Tumor Growth via Apoptotic Death Program Activation in Cell and Xenograft Animal Models

Po-Han Lin et al.

ANTIOXIDANTS (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Antileishmanial activity of the chalcone derivative LQFM064 associated with reduced fluidity in the parasite membrane as assessed by EPR spectroscopy

Lais Alonso et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

添加到收藏夹

Article Biology

Ultrastructural alterations in Plasmodium falciparum induced by chalcone derivatives

Shweta Sinha et al.

BMC RESEARCH NOTES (2020)

添加到收藏夹

Article Infectious Diseases

Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis

Stephen M. Christensen et al.

PLOS NEGLECTED TROPICAL DISEASES (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

In vitro antileishmanial and cytotoxic activities of nerolidol are associated with changes in plasma membrane dynamics

Lais Alonso et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2019)

添加到收藏夹

Article Biophysics

Interactions of miltefosine with erythrocyte membrane proteins compared to those of ionic surfactants

Lais Alonso et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

添加到收藏夹

Article Biophysics

Antileishmanial and cytotoxic activities of ionic surfactants compared to those of miltefosine

Lais Alonso et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Leishmaniasis: treatment, drug resistance and emerging therapies

Shyam Sundar et al.

EXPERT OPINION ON ORPHAN DRUGS (2019)

添加到收藏夹

Review Chemistry, Medicinal

A comprehensive review of chalcone derivatives as antileishmanial agents

Marcos Vinicius Palmeira de Mello et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

添加到收藏夹

Article Oncology

Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2′, 4′-Tetrahydroxychalcone

Changliang Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

A novel chalcone derivative, LQFM064, induces breast cancer cells death via p53, p21, KIT and PDGFRA

Bruna Lannuce Silva Cabral et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

The cytotoxic activity of miltefosine against Leishmania and macrophages is associated with dynamic changes in plasma membrane proteins

Kelly Souza Fernandes et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

Liposomal Amphotericin B (AmBisome®): A Review of the Pharmacokinetics, Pharmacodynamics, Clinical Experience and Future Directions

Neil R. H. Stone et al.

DRUGS (2016)

添加到收藏夹

Review Plant Sciences

Naturally occurring chalcones and their biological activities

Zsuzsanna Rozmer et al.

PHYTOCHEMISTRY REVIEWS (2016)

添加到收藏夹

Review Toxicology

Chalcone Scaffold in Anticancer Armamentarium: A Molecular Insight

Manik Das et al.

JOURNAL OF TOXICOLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

The molecular mechanism behind reactive aldehyde action on transmembrane translocations of proton and potassium ions

Olga Jovanovic et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria

Huiqin Zhong et al.

REDOX BIOLOGY (2015)

添加到收藏夹

Article Oncology

Advances in Chalcones with Anticancer Activities

Chandrabose Karthikeyan et al.

Recent Patents on Anti-Cancer Drug Discovery (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Fatty Acids are Key in 4-Hydroxy-2-Nonenal-Mediated Activation of Uncoupling Proteins 1 and 2

Elena A. Malingriaux et al.

PLOS ONE (2013)

添加到收藏夹

Article Biology

Electron paramagnetic resonance study of lipid and protein membrane components of erythrocytes oxidized with hydrogen peroxide

S. A. Mendanha et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2012)

添加到收藏夹

Article Chemistry, Medicinal

Trypanocidal Action of (-)-Elatol Involves an Oxidative Stress Triggered by Mitochondria Dysfunction

Vania Cristina Desoti et al.

MARINE DRUGS (2012)

添加到收藏夹

Article Genetics & Heredity

Dietary chalcones with chemopreventive and chemotherapeutic potential

Barbora Orlikova et al.

GENES AND NUTRITION (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions

Angel Catala

CHEMISTRY AND PHYSICS OF LIPIDS (2009)

添加到收藏夹

Article Chemistry, Medicinal

Structure-Activity Relationship Studies of Chalcone Leading to 3-Hydroxy-4,3′,4′,5′-tetramethoxychalcone and Its Analogues as Potent Nuclear Factor κB Inhibitors and Their Anticancer Activities

Balasubramanian Srinivasan et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

添加到收藏夹

Review Chemistry, Medicinal

4-hydroxynonenal: A membrane lipid oxidation product of medicinal interest

G. Poli et al.

MEDICINAL RESEARCH REVIEWS (2008)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidized phospholipids: From molecular properties to disease

Gilbert O. Fruhwirth et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)

添加到收藏夹

Article Parasitology

Further observations on clinical, histopathological, and immunological features of borderline disseminated cutaneous leishmaniasis caused by Leishmania (Leishmania) amazonensis

FT Silveira et al.

MEMORIAS DO INSTITUTO OSWALDO CRUZ (2005)

添加到收藏夹

Article Physiology

Mechanism of ivermectin facilitation of human P2X4 receptor channels

A Priel et al.

JOURNAL OF GENERAL PHYSIOLOGY (2004)

添加到收藏夹

Article Multidisciplinary Sciences

Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin

NS Kane et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.