Revisiting beta-dicyanovinyl substituted calix[4]pyrrole: Toward the chemodosimetric detection of hydrazine in solution

Noticeably, calix[4]pyrrole (C4P) derivatives have usually been employed to recognize charged species or polar guests through non-covalent supramolecular interactions, but the chemodosimetric approach remains scarce in the literature. In this study, the selective chemodosimetric detection and quantification of hydrazine, a hazardous pollutant commonly used in the industry, was performed using UV-spectroscopy with a repurposed beta-dicyanovinyl substituted calix[4]pyrrole sensor. The selectivity of the chemodosimeter towards hydrazine was evaluated in acetonitrile with various nucleophiles (nitrogen-containing compounds and a thiol). In addition, the influence of several parameters (time, water content, and temperature) on hydrazine detection by the sensor was evaluated. This study allows for the sensing of hydrazine with a limit of detection (LOD) of 1.3 mg/L, and a linear response in the 10-1000 mu M range. The ability to detect hydrazine with the naked eye has also been demonstrated. This paper reports one of the first chemodosimetric approach employed with calix[4]pyrrole to detect and quantify a neutral molecule, namely hydrazine.

Automated summary

In this study, a chemodosimetric approach using a repurposed calix[4]pyrrole sensor was developed for the selective detection and quantification of hydrazine. The sensor demonstrated a limit of detection of 1.3 mg/L and a linear response in the range of 10-1000 mu M for hydrazine. This study reports one of the first chemodosimetric approaches employed with calix[4]pyrrole for the detection and quantification of a neutral molecule, hydrazine.