☆ 4.7 Review

The role of immunosuppressive myofibroblasts in the aging process and age-related diseases

JOURNAL OF MOLECULAR MEDICINE-JMM (2023)

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Hepatic myofibroblasts exert immunosuppressive effects independent of the immune checkpoint regulator PD-L1 in liver metastasis of pancreatic ductal adenocarcinoma

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CELL (2023)

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Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression

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Immune checkpoint inhibitors as mediators for immunosuppression by cancer-associated fibroblasts: A comprehensive review

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Dor Lavie et al.

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Review Immunology

Immune ageing at single-cell resolution

Denis A. Mogilenko et al.

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Review Genetics & Heredity

Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases

Antero Salminen

Summary: 1. Low-grade inflammation is associated with aging and age-related diseases. 2. Persistent inflammation activates compensatory immunosuppression with aging. 3. The numbers of immunosuppressive cells increase with aging and age-related diseases. 4. Immunosuppressive mechanisms evoke harmful bystander effects in host tissues. 5. Immunosuppression promotes tissue degeneration with aging and age-related diseases.

JOURNAL OF MOLECULAR MEDICINE-JMM (2021)

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Ramasamy Selvarani et al.

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GEROSCIENCE (2021)

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Hypoperfusion is a potential inducer of immunosuppressive network in Alzheimer's disease

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Summary: Alzheimer's disease is a progressive neurodegenerative disease that causes irreversible cognitive impairment and dementia. Hypoxia and inflammation play important roles in AD pathology, with an enhanced immunosuppression state closely associated with AD pathogenesis.

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Zoe X. Malchiodi et al.

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Zhiran Zou et al.

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NLRP3 inflammasome activation in alveolar epithelial cells promotes myofibroblast differentiation of lung-resident mesenchymal stem cells during pulmonary fibrogenesis

Jie Ji et al.

Summary: The activation of NLRP3 inflammasome is elevated in fibrotic lungs, contributing to a better understanding of the pathogenesis of pulmonary fibrosis and revealing a potential therapeutic strategy for disorders associated with pulmonary fibrosis.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

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Review Medicine, General & Internal

Oxidative Stress Induced by Reactive Oxygen Species (ROS) and NADPH Oxidase 4 (NOX4) in the Pathogenesis of the Fibrotic Process in Systemic Sclerosis: A Promising Therapeutic Target

Sonsoles Piera-Velazquez et al.

Summary: Excessive oxidative stress caused by high levels of ROS has been implicated in the development of fibrosis in SSc, with NOX4 being suggested as a potential therapeutic target. The involvement of NOX4 in the production of fibrotic proteins and ROS, as well as its potential role in endothelial and vascular abnormalities, suggests it as a novel target for treating SSc.

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CD73-Mediated Immunosuppression Is Linked to a Specific Fibroblast Population That Paves the Way for New Therapy in Breast Cancer

Ilaria Magagna et al.

Summary: The study highlights the key role of CD73 in immunosuppressive CAF-S1 in breast cancer, showing that targeting CD73 can reduce CAF-S1-mediated immunosuppression. This provides a new promising therapeutic strategy for breast cancer patients.

CANCERS (2021)

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Review Cell Biology

Fibroblast Memory in Development, Homeostasis and Disease

Thomas Kirk et al.

Summary: Fibroblasts, as the major cell population in connective tissue of organs, play a key role in remodeling the extracellular matrix, but are also recognized as a highly diverse cell population that constantly responds and adapts to their environment.

CELLS (2021)

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Cross-tissue organization of the fibroblast lineage

Matthew B. Buechler et al.

Summary: Recent studies have identified fibroblast heterogeneity in different tissues, and constructed fibroblast atlases based on single-cell transcriptomic data to reveal universal and activated transcriptional subtypes in healthy and diseased states.

NATURE (2021)

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Review Immunology

Regulatory Immune Cells in Idiopathic Pulmonary Fibrosis: Friends or Foes?

Chiel van Geffen et al.

Summary: The immune system plays a crucial role in interstitial lung diseases, especially in the development and treatment response of pulmonary fibrosis. Understanding immune regulation is essential for the development of new therapeutic approaches for idiopathic pulmonary fibrosis.

FRONTIERS IN IMMUNOLOGY (2021)

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Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology

Moises Selman et al.

Summary: Ageing is a complex biological process involving multiple factors that lead to a decline in physiological functions and an increased risk of chronic diseases. Inflammageing and fibrotic pathways play key roles in age-related morbidities and the accumulation of extracellular matrix in the elderly. The concept of Fibroageing suggests that stiff ECM and activation of fibrotic positive feedback loops contribute to various age-related alterations.

AGEING RESEARCH REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Fibroblasts: Origins, definitions, and functions in health and disease

Maksim Plikus et al.

Summary: Fibroblasts are diverse mesenchymal cells that play a role in tissue homeostasis and disease, producing complex extracellular matrix and creating signaling niches. They are transcriptionally and functionally heterogeneous across and within organs, encoding positional information and maintaining distinct cellular progeny. Their unique properties make them poised for tissue repair but can also drive fibrotic disorders if activated aberrantly.

CELL (2021)

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Review Immunology

Fibroblasts as confederates of the immune system

Donovan Correa-Gallegos et al.

Summary: Fibroblastic stromal cells, diverse in origin and function, impact the immune system and challenge traditional views on their role as passive structural components. This review focuses on the complex interactions between different fibroblast populations and immune cells in the skin, emphasizing the relevance of fibroblast stromal cell heterogeneity in regulating the immune system. The study further highlights the evolving understanding of fibroblast influence on the immune system from embryonic development to adulthood.

IMMUNOLOGICAL REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Cellular Senescence in Lung Fibrosis

Fernanda Hernandez-Gonzalez et al.

Summary: Fibrosing interstitial lung diseases are chronic and fatal lung diseases characterized by the irreversible accumulation of scar tissue in the lung tissue. Cellular senescence, defined as a cell fate decision caused by unrepairable cellular damage, plays an important role in the initiation and progression of pulmonary fibrosis, likely by promoting molecular and cellular changes in chronic fibrosing processes. Targeting cellular senescence may be a potential therapeutic approach for treating fibrosing ILDs.

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Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions

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Summary: The functional competence of the immune system declines with aging, leading to immunosenescence. Involving both adaptive and innate immunity, immunosenescence is associated with chronic inflammation and a state called inflammaging. This process also occurs in pathological conditions, where persistent inflammation triggers compensatory immunosuppression.

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Advances in epigenetics in systemic sclerosis: molecular mechanisms and therapeutic potential

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Summary: Systemic sclerosis (SSc) is a complex inflammatory fibrotic disease with unknown etiology and partially understood pathogenesis, carrying the highest mortality rate among rheumatic diseases. Epigenetic aberrations play a crucial role in SSc pathogenesis, affecting immune cells, endothelial cells, and fibroblasts, presenting potential new avenues for therapeutic interventions.

NATURE REVIEWS RHEUMATOLOGY (2021)

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Epigenetic regulation in fibrosis progress

Taixiong Xue et al.

Summary: Fibrosis, a common process of chronic inflammatory diseases, leads to scar formation and functional failure in organs. Epigenetic mechanisms play a crucial role in fibrosis, involving DNA methylation, histone modification, ncRNAs, and m6A modification. Targeted therapy based on epigenetics holds great potential for treating fibrosis.

PHARMACOLOGICAL RESEARCH (2021)

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Lymph node fibroblastic reticular cells steer immune responses

Lushen Li et al.

Summary: This article summarizes the anatomical, phenotypic, and functional characteristics of FRC subsets in lymph nodes, discusses the changes in FRC during inflammation, and highlights the crosstalk between FRCs and immune cells. It emphasizes the state-of-the-art FRC-based therapeutic approaches for maintaining physiological homeostasis, steering protective immunity, inducing transplantation tolerance, and treating diverse immune-related diseases.

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G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence

Shu-Ning Sun et al.

Summary: The study identified an accumulation of G-MDSCs in the aging heart and demonstrated that the adoptive transfer of these cells from aging mice to young hearts resulted in cardiac dysfunction by inducing fibrosis. G-MDSCs promote cardiac fibrosis through the secretion of S100A8/A9 and regulation of the FGF2-SOX9 signaling pathway in fibroblasts during aging.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

Cheng-Cheng Deng et al.

Summary: This study examined fibroblast heterogeneity in keloid, a representative of fibrotic skin diseases, using single-cell RNA-seq. The results revealed that keloid fibroblasts could be divided into 4 subpopulations, with an increased percentage of mesenchymal fibroblasts playing a crucial role in collagen overexpression. This increased mesenchymal fibroblast subpopulation was also found in another fibrotic skin disease, scleroderma, suggesting a broad mechanism for skin fibrosis.

NATURE COMMUNICATIONS (2021)

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Review Immunology

Interpreting Immunoregulation in Lung Fibrosis: A New Branch of the Immune Model

Francoisz Huaux

Summary: This review highlights the potential implication of immunoregulation in lung fibrosis and the important role played by diverse immunoregulating populations. The presence of immunoregulatory cells, producing mediators that stimulate fibroblasts and matrix protein deposition, explains the development of fibrosis even in conditions where inflammatory cytokine deficiency or immunosuppressive therapies do not limit lung fibrosis. These findings suggest that refinement of therapeutic strategies in lung fibrotic disorders should take into account the persistent presence of immunoregulation.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Cell Biology

Cancer-Associated Fibroblast (CAF) Heterogeneity and Targeting Therapy of CAFs in Pancreatic Cancer

Xinglong Geng et al.

Summary: The roles of CAFs in PDAC are diverse, with different subtypes supporting or inhibiting cancer cell proliferation. As research progresses, CAFs may be a key factor in the treatment of pancreatic cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Medicine, Research & Experimental

Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming

Zhenzhen Li et al.

Summary: Cancer cells adapt their metabolism to proliferate and survive in harsh environments, with a close relationship between tumor microenvironment and cancer-associated fibroblasts (CAFs) playing key roles in tumor growth and metastasis. CAFs act as major regulators in shaping tumor metabolism, especially through dysregulation of metabolic pathways, influencing cancer cell behavior and response to therapy. The interaction and crosstalk between cancer cells and CAFs contribute to metabolic reprogramming that impacts cancer cell growth and progression.

THERANOSTICS (2021)

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Review Cell Biology

Autophagy in healthy aging and disease

Yahyah Aman et al.

Summary: This Review discusses the recent research on the mechanisms and roles of autophagy in health, aging, and disease, and how drugs modulating autophagy process could be used to suppress age-associated diseases. It examines emerging features of autophagy and proposes the potential links to aging and disease progression. The review also highlights the importance of understanding the interplay between autophagy and age-related pathologies for the development of clinical applications promoting long-term health.

NATURE AGING (2021)

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Review Cardiac & Cardiovascular Systems

Cardiac fibrosis

Nikolaos G. Frangogiannis

Summary: Myocardial fibrosis, characterized by the expansion of cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic feature in various myocardial conditions. Activated fibroblasts and myofibroblasts play a central role in cardiac fibrosis, producing matrix proteins and triggering fibrogenic signalling cascades in response to stress. Immune cells, vascular cells, and cardiomyocytes can also contribute to fibrosis, while fibrotic changes may disrupt cardiac function and play a role in arrhythmogenesis.

CARDIOVASCULAR RESEARCH (2021)

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Review Immunology

Fibroblasts as immune regulators in infection, inflammation and cancer

Sarah Davidson et al.

Summary: In different tissues and diseases, fibroblasts play a crucial role in regulating local immune responses by modulating inflammatory or immunosuppressive activities. Their diverse immunological properties highlight the importance of tissue context in determining fibroblast-immune cell interactions.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Cell Biology

Crosstalk between cancer-associated fibroblasts and immune cells in cancer

Yuanyuan An et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Review Cell Biology

Activation of immunosuppressive network in the aging process

Antero Salminen

AGEING RESEARCH REVIEWS (2020)

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Article Biochemistry & Molecular Biology

Impaired Myofibroblast Dedifferentiation Contributes to Nonresolving Fibrosis in Aging

Kosuke Kato et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Origin and functional heterogeneity of fibroblasts

Valerie S. LeBleu et al.

FASEB JOURNAL (2020)

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Review Cell Biology

mTOR at the nexus of nutrition, growth, ageing and disease

Grace Y. Liu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Cell Biology

TGF-β1-A truly transforming growth factor in fibrosis and immunity

Monika Lodyga et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

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Review Cell Biology

Benefits of Metformin in Attenuating the Hallmarks of Aging

Ameya S. Kulkarni et al.

CELL METABOLISM (2020)

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Article Cell & Tissue Engineering

Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair

Brett A. Shook et al.

CELL STEM CELL (2020)

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Article Cardiac & Cardiovascular Systems

Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression

Monika Sharma et al.

CIRCULATION RESEARCH (2020)

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Article Cell Biology

IL-18/IL-18R1 promotes circulating fibrocyte differentiation in the aging population

Xiao-Hui Niu et al.

INFLAMMATION RESEARCH (2020)

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Article Oncology

Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer

Yann Kieffer et al.

CANCER DISCOVERY (2020)

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Review Food Science & Technology

Inflammation and Premature Ageing in Chronic Kidney Disease

Thomas Ebert et al.

TOXINS (2020)

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Article Biochemistry & Molecular Biology

Cardiac fibroblast activation during myocardial infarction wound healing

Michael J. Daseke et al.

MATRIX BIOLOGY (2020)

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Review Immunology

Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)

Anu Kauppinen et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy

Micheal A. McLellan et al.

CIRCULATION (2020)

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Article Biochemistry & Molecular Biology

Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-β1

Raul Vivar et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

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Review Oncology

The role of fibroblast activation protein in health and malignancy

Allison A. Fitzgerald et al.

CANCER AND METASTASIS REVIEWS (2020)

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Article Pharmacology & Pharmacy

Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1

Anita A. Pinar et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

The Roles of Immune Cells in the Pathogenesis of Fibrosis

Enyu Huang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Immunology

Regulation of the Bone Marrow Niche by Inflammation

Ioannis Mitroulis et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

Bi-directional communication: Conversations between fibroblasts and immune cells in systemic sclerosis

Julie C. Worrell et al.

JOURNAL OF AUTOIMMUNITY (2020)

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Article Biology

Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

Llorenc Sole-Boldo et al.

COMMUNICATIONS BIOLOGY (2020)

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Review Cell Biology

Single-cell analyses of aging, inflammation and senescence

Bora Uyar et al.

AGEING RESEARCH REVIEWS (2020)

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Article Multidisciplinary Sciences

Structural cells are key regulators of organ-specific immune responses

Thomas Krausgruber et al.

NATURE (2020)

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Review Immunology

The interplay between immunosenescence and age-related diseases

Florencia Barbe-Tuana et al.

SEMINARS IN IMMUNOPATHOLOGY (2020)

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Review Immunology

Fibroblast heterogeneity in tumor micro-environment: Role in immunosuppression and new therapies

Rana Mhaidly et al.

SEMINARS IN IMMUNOLOGY (2020)

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Article Rheumatology

Adipocytic Progenitor Cells Give Rise to Pathogenic Myofibroblasts: Adipocyte-to-Mesenchymal Transition and Its Emerging Role in Fibrosis in Multiple Organs

Roberta Goncalves Marangoni et al.

CURRENT RHEUMATOLOGY REPORTS (2020)

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Review Cell Biology

Fibroblast Senescence in Idiopathic Pulmonary Fibrosis

Yifan Lin et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Mechanical and Physical Regulation of Fibroblast-Myofibroblast Transition: From Cellular Mechanoresponse to Tissue Pathology

Mirko D'Urso et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Review Oncology

Immunosenescence: a key player in cancer development

Jingyao Lian et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Review Immunology

The untwining of immunosenescence and aging

Weili Xu et al.

SEMINARS IN IMMUNOPATHOLOGY (2020)

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Review Cell Biology

Mechanosensing dysregulation in the fibroblast: A hallmark of the aging heart

Aude Angelini et al.

AGEING RESEARCH REVIEWS (2020)

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Review Oncology

Mechanical regulation of myofibroblast phenoconversion and collagen contraction

Boris Hinz et al.

EXPERIMENTAL CELL RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

Berenice A. Benayoun et al.

GENOME RESEARCH (2019)

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Article Oncology

Premature Aging in Young Cancer Survivors

Saro H. Armenian et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

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Review Biochemistry & Molecular Biology

Lactate: A Metabolic Driver in the Tumour Landscape

Luigi Ippolito et al.

TRENDS IN BIOCHEMICAL SCIENCES (2019)

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Article Cell Biology

Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer

Rongsheng Zhang et al.

CELL DEATH & DISEASE (2019)

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Article Multidisciplinary Sciences

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

Christian F. Guerrero-Juarez et al.

NATURE COMMUNICATIONS (2019)

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Article Pharmacology & Pharmacy

The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma

Erik Ladomersky et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Cell Biology

Primary Human Fibroblasts in Culture Switch to a Myofibroblast-Like Phenotype Independently of TGF Beta

Ulrike Baranyi et al.

CELLS (2019)

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Review Immunology

The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment

Lea Monteran et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Increased mitochondrial NADPH oxidase 4 (NOX4) expression in aging is a causative factor in aortic stiffening

Chandrika Canugovi et al.

REDOX BIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Fibroblasts and Their Pathological Functions in the Fibrosis of Aortic Valve Sclerosis and Atherosclerosis

Savita Singh et al.

BIOMOLECULES (2019)

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Review Biochemistry & Molecular Biology

Immunobiology of Atherosclerosis: A Complex Net of Interactions

Beatriz Herrero-Fernandez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Cell Biology

Regulatory Mechanisms of Inhibitory Immune Checkpoint Receptor Expression

Nicolas Curdy et al.

TRENDS IN CELL BIOLOGY (2019)

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Article Biology

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

Tushar D. Bhagat et al.

ELIFE (2019)

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Article Oncology

Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation

Giada Amodio et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

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Review Physiology

Mechanisms for the Resolution of Organ Fibrosis

Jeffrey C. Horowitz et al.

PHYSIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Chronic inflammation in the etiology of disease across the life span

David Furman et al.

NATURE MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Defining the Activated Fibroblast Population in Lung Fibrosis Using Single-Cell Sequencing

Rebecca Peyser et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency

Antero Salminen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Article Medicine, Research & Experimental

Transcriptions heterogeneity of fibroblasts is a hallmark of the aging heart

Ramon Vidal et al.

JCI INSIGHT (2019)

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Review Oncology

Fibroblasts Fuel Immune Escape in the Tumor Microenvironment

Emiel A. De Jaeghere et al.

TRENDS IN CANCER (2019)

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Article Oncology

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

Ana Costa et al.

CANCER CELL (2018)

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Review Biochemistry & Molecular Biology

The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

Jessica Lawrence et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Medicine, Research & Experimental

Resolution of organ fibrosis

Joon-Il Jun et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Review Oncology

Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer

Kirsten K. Ness et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Article Dermatology

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

Christina Philippeos et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

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Article Biochemistry & Molecular Biology

Metformin reverses established lung fibrosis in a bleomycin model

Sunad Rangarajan et al.

NATURE MEDICINE (2018)

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Review Critical Care Medicine

LACTATE AND IMMUNOSUPPRESSION IN SEPSIS

Benjamin Nolt et al.

SHOCK (2018)

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Article Cell Biology

M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia

Jindong Sheng et al.

CELL DEATH & DISEASE (2018)

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Review Immunology

Alteration of the Antitumor immune Response by Cancer-Associated Fibroblasts

Linda Ziani et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Cell Biology

The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process

Antero Salminen et al.

AGEING RESEARCH REVIEWS (2018)

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Article Cell Biology

Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts

Neetu Razdan et al.

AGING CELL (2018)

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Article Cell Biology

M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis

Jiwei Hou et al.

CELL COMMUNICATION AND SIGNALING (2018)

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Review Immunology

Unraveling SSc Pathophysiology; The Myofibroblast

Arjan van Caam et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Medicine, General & Internal

Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration - the potential sources and molecular cues for their recruitment and activation

Karis Little et al.

EBIOMEDICINE (2018)

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Review Physiology

Regulatory T cells in acute and chronic kidney diseases

Rahul Sharma et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2018)

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Article Cell Biology

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis

Massimiliano Mellone et al.

AGING-US (2017)

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Article Immunology

Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis

S. L. Ashley et al.

MUCOSAL IMMUNOLOGY (2017)

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Article Immunology

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Daniel Ohlund et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Review Cell Biology

Matricellular proteins tune myeloid-derived suppressor cell recruitment and function in breast cancer

Claudia Chiodoni et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2017)

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Article Oncology

HMGB1 induces lung fibroblast to myofibroblast differentiation through NF-κB-mediated TGF-β1 release

Qiong Wang et al.

MOLECULAR MEDICINE REPORTS (2017)

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Article Respiratory System

Characteristics and potential role of M2 macrophages in COPD

Shengyang He et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2017)

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Review Immunology

Resident fibroblasts in the kidney: a major driver of fibrosis and inflammation

Yuki Sato et al.

INFLAMMATION AND REGENERATION (2017)

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Article Medicine, Research & Experimental

Human pericytes adopt myofibroblast properties in the microenvironment of the IPF lung

Parid Sava et al.

JCI INSIGHT (2017)

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Review Oncology

Biology of premature ageing in survivors of cancer

Margaret C. Cupit-Link et al.

ESMO OPEN (2017)

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Article Biochemistry & Molecular Biology

The role of matrix metalloproteinases in aging: Tissue remodeling and beyond

Sandra Freitas-Rodriguez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)

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Article Cell Biology

AMPK orchestrates an elaborate cascade protecting tissue from fibrosis and aging

Shuai Jiang et al.

AGEING RESEARCH REVIEWS (2017)

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Article Critical Care Medicine

Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome

Juan C. Mira et al.

CRITICAL CARE MEDICINE (2017)

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Review Geriatrics & Gerontology

Inflammaging decreases adaptive and innate immune responses in mice and humans

Daniela Frasca et al.

BIOGERONTOLOGY (2016)

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Article Oncology

TGF-β/Smad3 signalling regulates the transition of bone marrow-derived macrophages into myofibroblasts during tissue fibrosis

Shuang Wang et al.

ONCOTARGET (2016)

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Article Pathology

CD4+CD25hiFoxp3+ Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis

Shirin Z. Birjandi et al.

AMERICAN JOURNAL OF PATHOLOGY (2016)

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Article Cardiac & Cardiovascular Systems

Enhanced neointimal fibroblast, myofibroblast content and altered extracellular matrix composition: Implications in the progression of human peripheral artery restenosis

Prakash Krishnan et al.

ATHEROSCLEROSIS (2016)

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Article Oncology

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling

Xuguang Yang et al.

CANCER RESEARCH (2016)

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Review Cell Biology

Reactive oxygen species and fibrosis: further evidence of a significant liaison

Kati Richter et al.

CELL AND TISSUE RESEARCH (2016)

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Article Cardiac & Cardiovascular Systems

Interleukin 18 promotes myofibroblast activation of valvular interstitial cells

Jingxin Zhou et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

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Article Biochemistry & Molecular Biology

NADPH Oxidases Are Essential for Macrophage Differentiation

Qing Xu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Article Cell Biology

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis

Xiao-Ming Meng et al.

CELL DEATH & DISEASE (2016)

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Article Multidisciplinary Sciences

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

Megan K. Ruhland et al.

NATURE COMMUNICATIONS (2016)

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Review Immunology

Natural Killer Cells and Liver Fibrosis

Frank Fasbender et al.

FRONTIERS IN IMMUNOLOGY (2016)

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Review Biochemistry & Molecular Biology

Redox mechanisms in age-related lung fibrosis

Ashish Kurundkar et al.

REDOX BIOLOGY (2016)

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Article Multidisciplinary Sciences

Resveratrol-Mediated Repression and Reversion of Prostatic Myofibroblast Phenoconversion

Mehrnaz Gharaee-Kermani et al.

PLOS ONE (2016)

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Article Respiratory System

Metformin attenuates lung fibrosis development via NOX4 suppression

Nahoko Sato et al.

RESPIRATORY RESEARCH (2016)

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Article Pathology

FIZZ1-Induced Myofibroblast Transdifferentiation from Adipocytes and Its Potential Rote in Dermal Fibrosis and Lipoatrophy

Vanessa Martins et al.

AMERICAN JOURNAL OF PATHOLOGY (2015)

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Review Oncology

Immunosuppression associated with chronic inflammation in the tumor microenvironment

Dingzhi Wang et al.

CARCINOGENESIS (2015)

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Review Immunology

The expanding family of regulatory B cells

Claudia Mauri et al.

INTERNATIONAL IMMUNOLOGY (2015)

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Article Multidisciplinary Sciences

Physiological ER Stress Mediates the Differentiation of Fibroblasts

Shinsuke Matsuzaki et al.

PLOS ONE (2015)

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Review Medicine, General & Internal

Signaling in fibrosis: TGF-beta, wNT, and YAP/TAZ converge

Bram Piersma et al.

FRONTIERS IN MEDICINE (2015)

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Article Cardiac & Cardiovascular Systems

Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function

Amit Saxena et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2014)

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Review Cardiac & Cardiovascular Systems

Crosstalk between fibroblasts and inflammatory cells

Sophie Van Linthout et al.

CARDIOVASCULAR RESEARCH (2014)

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Review Pharmacology & Pharmacy

Reversal of myofibroblast differentiation: A review

XiaoHong Yang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2014)

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Review Immunology

tTregs, pTregs, and iTregs: similarities and differences

Ethan M. Shevach et al.

IMMUNOLOGICAL REVIEWS (2014)

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Review Cell Biology

The hallmarks of fibroblast ageing

Julia Tigges et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2014)

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Article Multidisciplinary Sciences

The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts

Kuan-Hsing Chen et al.

PLOS ONE (2014)

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Review Immunology

Extracellular adenosine-mediated modulation of regulatory T cells

Akio Ohta et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Article Cell Biology

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice

Connie Jackaman et al.

AGING CELL (2013)

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Review Immunology

The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells

Dennis Lindau et al.

IMMUNOLOGY (2013)

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Article Immunology

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

Zaheed Husain et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Cell Biology

Blood CD33(+)HLA-DR(-) myeloid-derived suppressor cells are increased with age and a history of cancer

Chris P. Verschoor et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2013)

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Article Cell Biology

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Juan Carlos Acosta et al.

NATURE CELL BIOLOGY (2013)

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Article Biochemistry & Molecular Biology

Histone Modifications in Senescence-Associated Resistance to Apoptosis by Oxidative Stress

Yan Y. Sanders et al.

REDOX BIOLOGY (2013)

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Article Ophthalmology

Rapamycin Inhibits the Production of Myofibroblasts and Reduces Corneal Scarring After Photorefractive Keratectomy

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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)

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Review Cell Biology

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

Antero Salminen et al.

AGEING RESEARCH REVIEWS (2012)

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Article Biochemistry & Molecular Biology

Involvement of Endoplasmic Reticulum Stress in Myofibroblastic Differentiation of Lung Fibroblasts

Hyun Ah Baek et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2012)

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Article Immunology

TGFβ signaling plays a critical role in promoting alternative macrophage activation

Dapeng Gong et al.

BMC IMMUNOLOGY (2012)

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Review Oncology

Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression

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CANCER AND METASTASIS REVIEWS (2012)

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Article Oncology

Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay

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CANCER RESEARCH (2012)

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Article Cell Biology

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth Connecting TGF-β signaling with Warburg-like cancer metabolism and L-lactate production

Carmela Guido et al.

CELL CYCLE (2012)

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Review Biochemistry & Molecular Biology

Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases

Antero Salminen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

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Review Cell Biology

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

Antero Salminen et al.

CELLULAR SIGNALLING (2012)

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Article Multidisciplinary Sciences

CXC-Type Chemokines Promote Myofibroblast Phenoconversion and Prostatic Fibrosis

Mehrnaz Gharaee-Kermani et al.

PLOS ONE (2012)

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Review Oncology

New insights into chronic inflammation-induced immunosuppression

Julia Kanterman et al.

SEMINARS IN CANCER BIOLOGY (2012)

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Review Immunology

Cellular and molecular mechanisms of chronic inflammation-associated organ fibrosis

Satoshi Ueha et al.

FRONTIERS IN IMMUNOLOGY (2012)

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Article Hematology

Myofibroblast-Mediated Adventitial Remodeling An Underestimated Player in Arterial Pathology

Matteo Coen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)

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Review Biochemistry & Molecular Biology

Apoptosis and aging: increased resistance to apoptosis enhances the aging process

Antero Salminen et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

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Article Oncology

Reversible differentiation of myofibroblasts by MyoD

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EXPERIMENTAL CELL RESEARCH (2011)

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Article Gastroenterology & Hepatology

Human Colonic Myofibroblasts Promote Expansion of CD4+ CD25high Foxp3+ Regulatory T Cells

Irina V. Pinchuk et al.

GASTROENTEROLOGY (2011)

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Article Immunology

A Role for Immature Myeloid Cells in Immune Senescence

Elena Y. Enioutina et al.

JOURNAL OF IMMUNOLOGY (2011)

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Article Immunology

Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells

Sergey Ryzhov et al.

JOURNAL OF IMMUNOLOGY (2011)

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Article Immunology

Immunological consequences of ischemic stroke: Immunosuppression and autoimmunity

Antje Vogelgesang et al.

JOURNAL OF NEUROIMMUNOLOGY (2011)

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Review Urology & Nephrology

Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

Jeffrey L. Barnes et al.

KIDNEY INTERNATIONAL (2011)

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Article Endocrinology & Metabolism

ROS Signaling by NOX4 Drives Fibroblast-to-Myofibroblast Differentiation in the Diseased Prostatic Stroma

Natalie Sampson et al.

MOLECULAR ENDOCRINOLOGY (2011)

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Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

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Article Multidisciplinary Sciences

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

Wendy W. Pang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Pathology

Epigenetic Regulation of Myofibroblast Differentiation by DNA Methylation

Biao Hu et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

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Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

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Article Medicine, Research & Experimental

Oxidative stress promotes myofibroblast differentiation and tumour spreading

Aurore Toullec et al.

EMBO MOLECULAR MEDICINE (2010)

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Article Multidisciplinary Sciences

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species

Marina D. Kraaij et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Review Biochemistry & Molecular Biology

Inflammatory networks during cellular senescence: causes and consequences

Adam Freund et al.

TRENDS IN MOLECULAR MEDICINE (2010)

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Article Immunology

NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

Jurg Tschopp et al.

NATURE REVIEWS IMMUNOLOGY (2010)

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Article Biochemistry & Molecular Biology

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Kandice R. Levental et al.

CELL (2009)

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Article Cell Biology

Integrin α1β1 is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo

Alejandro Rodriguez et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)

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Article Gastroenterology & Hepatology

Rapamycin Inhibits Hepatic Fibrosis in Rats by Attenuating Multiple Profibrogenic Pathways

Kim R. Bridle et al.

LIVER TRANSPLANTATION (2009)

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Review Immunology

Myeloid-derived suppressor cells as regulators of the immune system

Dmitry I. Gabrilovich et al.

NATURE REVIEWS IMMUNOLOGY (2009)

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Article Physiology

Peroxynitrite augments fibroblast-mediated tissue remodeling via myofibroblast differentiation

Tomohiro Ichikawa et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)

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Article Cardiac & Cardiovascular Systems

Osteopontin expression is required for myofibroblast differentiation

Yair Lenga et al.

CIRCULATION RESEARCH (2008)

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Review Immunology

Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90

Antero Salminen et al.

IMMUNOLOGY LETTERS (2008)

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Article Biochemistry & Molecular Biology

AMP-activated protein kinase inhibits transforming growth factor-β-induced Smad3-dependent transcription and myofibroblast transdifferentiation

Rangnath Mishra et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Review Immunology

Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation

Celine S. Lages et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Biochemistry & Molecular Biology

Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

Srinivas Nagaraj et al.

NATURE MEDICINE (2007)

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Article Immunology

High accumulation of T regulatory cells prevents the activation of immune responses in aged animals

Sanjay Sharma et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Biochemistry & Molecular Biology

Telomerase regulation of myofibroblast differentiation

T Liu et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2006)

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Article Rheumatology

Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes

Stefan Bauer et al.

ARTHRITIS RESEARCH & THERAPY (2006)

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Article Cardiac & Cardiovascular Systems

NAD(P)H oxidase 4 mediates transforming growth factor-β1-induced differentiation of cardiac fibroblasts into myofibroblasts

I Cucoranu et al.

CIRCULATION RESEARCH (2005)

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Article Multidisciplinary Sciences

Diversity, topographic differentiation, and positional memory in human fibroblasts

HY Chang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

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