13-cyclodextrin-based nanosponges for crocetin delivery: Physicochemical characterization, aqueous solubility, and bioactivity

Article Chemistry, Multidisciplinary

Cannabidiol/hydroxypropyl-β-cyclodextrin inclusion complex: structure analysis, release behavior, permeability, and bioactivity under in vitro digestion

Hang Li et al.

Summary: The study found that forming an inclusion complex of CBD with hydroxypropyl-beta-cyclodextrin greatly improved the solubility and enhanced the permeability and antioxidant capacity of CBD.

NEW JOURNAL OF CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Formulation and modification of physicochemical parameters of p-Coumaric acid by cyclodextrin nanosponges

Anil Kumar et al.

Summary: This study aimed to fabricate p-Coumaric acid loaded nanosponges using the melt method and characterize their properties. The results showed that the preparation method enhanced the efficacy of p-Coumaric acid, improved safety and release, and demonstrated potential applications.

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY (2022)

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Article Instruments & Instrumentation

Partial inclusion complex assisted crosslinked β-cyclodextrin nanoparticles for improving therapeutic potential of docetaxel against breast cancer

Sanyog Jain et al.

Summary: The study developed crosslinked beta-cyclodextrin nanoparticles for enhancing the therapeutic efficacy of docetaxel against breast cancer. The nanoparticles showed improved drug loading efficiency and demonstrated enhanced cellular uptake, cytotoxicity, and apoptosis in breast cancer cells. Pharmacokinetic evaluation revealed increased drug exposure and retention time, while anti-tumor activity in a cancer model showed significant reduction in tumor volume compared to the standard drug. Toxicity assessment indicated no short-term nephrotoxicity, suggesting the potential of the formulation strategy to improve the therapeutic effectiveness of docetaxel.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Article Pharmacology & Pharmacy

Developing Novel Hydroxypropyl-β-Cyclodextrin-Based Nanosponges as Carriers for Anticancer Hydrophobic Agents: Overcoming Limitations of Host-Guest Complexes in a Comparative Evaluation

Shohreh Peimanfard et al.

Summary: This study aimed to design and fabricate novel hydroxypropyl-beta-cyclodextrin-based hypercrosslinked polymers, called nanosponges, as carriers for anticancer hydrophobic agents and compare them with host-guest complexes of hydroxypropyl-beta-cyclodextrin. The results showed that the nanosponges had higher drug loading capacity and stronger anticancer effects.

PHARMACEUTICS (2022)

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Article Chemistry, Applied

Degree of crosslinking in β-cyclodextrin-based nanosponges and their effect on piperine encapsulation

Juan Guineo-Alvarado et al.

Summary: The study successfully synthesized beta-cyclodextrin nanosponges using microwave-assisted fusion for encapsulating Piperine. The degree of substitution and crystallinity increased with the concentration of diphenyl carbonate. Highly crosslinked nanosponges showed improved loading efficiency, demonstrating the feasibility of high-capacity encapsulation.

FOOD CHEMISTRY (2021)

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Article Plant Sciences

Crocetin ameliorates chronic restraint stress-induced depression-like behaviors in mice by regulating MEK/ERK pathways and gut microbiota

Susu Lin et al.

Summary: The study shows that saffron can alleviate depressive-like behaviors induced by chronic stress, regulate biochemical markers, protect neuronal cells, modulate signaling pathways in the hippocampus, and partially restore damaged intestinal microbiota.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Chemistry, Applied

Crocetin Exerts a Cardio-protective Effect on Mice with Coxsackievirus B3-induced Acute Viral Myocarditis

Li Qin et al.

Summary: The study demonstrated that crocetin has a cardio-protective effect in an experimental murine model of acute viral myocarditis, increasing survival rates, reducing myocardial necrotic lesions, and inhibiting viral replication and inflammatory response. These findings suggest that crocetin may be a potential therapeutic agent for patients with viral myocarditis.

JOURNAL OF OLEO SCIENCE (2021)

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Article Chemistry, Applied