Analysis experimental and modeling of the solubility of an antiepileptic drug, Levetiracetam, in supercritical solvent

To formulate efficient drug delivery systems by a suitable supercritical method, the solubility of drugs in the supercritical solvent like supercritical carbon dioxide (scCO2) must be determined. In this study, solubility of Levetiracetam, a well-known antiepileptic drug, in scCO2 was studied at 308 to 338 K and 120 to 300 bar. It was obtained between the mole fractions of 2 x 10-5 to 3.05 x 10-4 and 0.03 to 0.96 kg.m- 3. Also, this process was modelled using various theoretical models (empirical (Chrastil, Bartle, Kumar and Johnston (KJ) and Mendez-Santiago-Teja (MST)), PC-SAFT, SRK, and modified Wilson). All the models show the acceptable results and the deviation among the experimental and model-calculated data are satisfactory. Among them, the optimized Wilson's model (AARD% = 6.66) and the empirical model proposed by Bartle (AARD% = 13.96) show the highest and the lowest precision, respectively. Also, the total mixing, evaporation, and solvation thermal enthalpies for the Levetiracetam-scCO2 system are computed using the empirical models.

Automated summary

This study investigates the solubility of Levetiracetam in supercritical carbon dioxide (scCO2) and models the process using various theoretical models. The results show acceptable precision and provide valuable data for the formulation of efficient drug delivery systems.