Tnni3k influences cardiomyocyte S-phase activity and proliferation

Cardiomyocyte proliferation is a difficult phenomenon to capture and prove. Here we employ a retrospective analysis of single cell ventricular suspensions to definitively identify cardiomyocytes that have completed cell division. Through this analysis we determined that the capacity of cardiomyocytes to re-enter the cell cycle and complete cell division after injury are separate and variable traits. Further, we provide evidence that Tnni3k definitively influences both early and final stages of the cell cycle.

Automated summary

We conducted a retrospective analysis of single cell ventricular suspensions to identify cardiomyocytes that have completed cell division. Our findings indicate that the ability of cardiomyocytes to re-enter the cell cycle and complete cell division after injury is independent and variable. Additionally, we provide evidence that Tnni3k influences both early and final stages of the cell cycle.