Structural Patterns Enhancing the Antibacterial Activity of Metallacarborane-Based Antibiotics

Healthcare systems heavily rely on antibiotics to treat bacterial infections, but the widespread presence of multidrug-resistant bacteria puts this strategy in danger. Novel drugs capable of overcoming current resistances are needed if our ability to treat bacterial infections is to be maintained. Boron clusters offer a valuable possibility to create a new class of antibiotics and expand the chemical space of antibiotics beyond conventional carbon-based molecules. In this work, we identified two promising structural patterns providing cobalta bis(dicarbollide)(COSAN)-based compounds with potent and selective activity toward Staphylococcus aureus (including clinical strains): introduction of the alpha-amino acid amide and addition of iodine directly to the metallacarborane cage. Furthermore, we found that proper hydrophilic-lipophilic balance is crucial for the selective activity of the tested compounds toward S. aureus over mammalian cells. The patterns proposed in this paper can be useful in the development of metallacarborane-based antibiotics with potent antibacterial properties and low cytotoxicity.

Automated summary

This research identified two promising structural patterns that provide COSAN-based compounds with potent and selective activity against Staphylococcus aureus. Additionally, proper hydrophilic-lipophilic balance was found to be crucial for the selective activity of the tested compounds. These patterns could be useful in the development of metallacarborane-based antibiotics with strong antibacterial properties and low cytotoxicity.