Designed ultrafine polymer-coated manganese-cobalt ferrite nanoparticles loaded with anticancer drug: efficacy enhancement through host:guest complexation on the polymer surface

Magnetic nanomaterials of different compositions have been examined, focusing on the magnetic field-directed transport of drugs. The size, shape, surface modification and composition variations make every magnetic nanostructure a unique nanocarrier. In this work, we carry out a hydrothermal synthesis of novel manganese-cobalt co-incorporated magnetic ferrite nanoparticles. The particles are characterized using x-ray diffraction, transmission electron microscopy, thermogravimetry and x-ray photoelectron spectroscopy. The size of the nanoparticles is below 10 nm, and they are found to fall under the face-centered cubic system. The nanoparticles are coated with the & beta;-cyclodextrin and folate co-tethered polyethylene glycol. Vibrating sample magnetometry reveals the soft ferromagnetic nature of the nanoparticles with a saturation magnetization value of 28.11 emu g(-1) for the coated nanoparticles. The polymer on the nanoparticles allows the loading of the drug feasible, and the encapsulation efficiency is & SIM;93%. The in vitro release of the drug is monitored and it is observed that the release occurs over 130 h. The cytotoxicity of the free- and camptothecin-loaded manganese-ferrite nanocarrier on breast cancer cell lines is investigated. The IC50 value of the drug-loaded nanocarrier is 2.22 & mu;g mL(-1) which is significantly lower than that of the free drug. The drug-encapsulated nanocarrier releases the cargo slowly and continuously and shows increased efficacy, which represents the significance of the nanocarrier. The results present the designed nanomaterial as a suitable anticancer drug vehicle.

Automated summary

Different magnetic nanomaterials were studied, with a focus on the transport of drugs under a magnetic field. The unique characteristics of each magnetic nanostructure, such as size, shape, surface modification, and composition, make them suitable as nanocarriers. In this study, novel manganese-cobalt co-incorporated magnetic ferrite nanoparticles were synthesized hydrothermally and characterized. These nanoparticles were coated with β-cyclodextrin, folate, and polyethylene glycol, allowing for effective drug loading with a high encapsulation efficiency of approximately 93%. The drug-loaded nanocarriers exhibited a slow and sustained release of the drug over 130 hours, showing increased efficacy compared to the free drug. The results highlight the significance of these designed nanocarriers as potential anticancer drug vehicles.