相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase
Julie Ducharme et al.
BIOCHEMISTRY (2021)
A dynamic understanding of cytochrome P450 structure and function through solution NMR
Thomas C. Pochapsky
CURRENT OPINION IN BIOTECHNOLOGY (2021)
Dynamics and Location of the Allosteric Midazolam Site in Cytochrome P4503A4 in Lipid Nanodiscs
Michelle Redhair et al.
BIOCHEMISTRY (2020)
Imidazolium Compounds as Internal Exchange Reporters for Hydrogen/Deuterium Exchange by Mass Spectrometry
Taylor A. Murphree et al.
ANALYTICAL CHEMISTRY (2020)
Dynamics and Mechanism of Binding of Androstenedione to Membrane-Associated Aromatase
Lorela Paco et al.
BIOCHEMISTRY (2020)
Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments
Ingvar R. Moller et al.
ANALYTICAL CHEMISTRY (2019)
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
Glenn R. Masson et al.
NATURE METHODS (2019)
Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro
Xiao-Yang Zhou et al.
FRONTIERS IN PHARMACOLOGY (2019)
Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, Azamulin and 6′,7′-Dihydroxybergamottin
Irina F. Sevrioukova
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Cytochrome P450-The Wonderful Nanomachine Revealed through Dynamic Simulations of the Catalytic Cycle
Kshatresh Dutta Dubey et al.
ACCOUNTS OF CHEMICAL RESEARCH (2019)
Probing protein-protein and protein-substrate interactions in the dynamic membrane-associated ternary complex of cytochromes P450, b5, and reductase
Katherine A. Gentry et al.
CHEMICAL COMMUNICATIONS (2019)
A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs
Elke Prade et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
Cytochrome-P450-Induced Ordering of Microsomal Membranes Modulates Affinity for Drugs
Carlo Barnaba et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
Membrane-embedded substrate recognition by cytochrome P450 3A4
John C. Hackett
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Refining Markov state models for conformational dynamics using ensemble-averaged data and time-series trajectories
Y. Matsunaga et al.
JOURNAL OF CHEMICAL PHYSICS (2018)
Membrane-attached mammalian cytochromes P450: An overview of the membrane's effects on structure, drug binding, and interactions with redox partners
Martin Srejber et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2018)
Gaussian Accelerated Molecular Dynamics in NAMD
Yui Tik Pang et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2017)
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
Jing Huang et al.
NATURE METHODS (2017)
Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4
Irina F. Sevrioukova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Challenges in assignment of allosteric effects in cytochrome P450-catalyzed substrate oxidations to structural dynamics in the hemoprotein architecture
Peter Hlavica
JOURNAL OF INORGANIC BIOCHEMISTRY (2017)
High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4
Irina F. Sevrioukova
BIOCHEMISTRY (2017)
Nanodiscs in Membrane Biochemistry and Biophysics
Ilia G. Denisov et al.
CHEMICAL REVIEWS (2017)
Membrane Interactions, Ligand-Dependent Dynamics, and Stability of Cytochrome P4503A4 in Lipid Nanodiscs
Nicholas A. Treuheit et al.
BIOCHEMISTRY (2016)
Membrane Fluidity Modulates Thermal Stability and Ligand Binding of Cytochrome P4503A4 in Lipid Nanodiscs
Wynton D. McClary et al.
BIOCHEMISTRY (2016)
Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy
Dmitri R. Davydov et al.
BIOPHYSICAL JOURNAL (2016)
Role of Enzyme Flexibility in Ligand Access and Egress to Active Site: Bias-Exchange Metadynamics Study of 1,3,7-Trimethyluric Acid in Cytochrome P450 3A4
Marketa Paloncyova et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2016)
Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding
An Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals
Slobodan Rendic et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2015)
Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone
Dmitri R. Davydov et al.
BIOCHEMICAL JOURNAL (2013)
Behavior of Human Cytochromes P450 on Lipid Membranes
Karel Berka et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2013)
Analysis of Overlapped and Noisy Hydrogen/Deuterium Exchange Mass Spectra
Miklos Guttman et al.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2013)
Protein hydrogen exchange at residue resolution by proteolytic fragmentation mass spectrometry analysis
Zhong-Yuan Kan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Is There a Relationship Between the Substrate Preferences and Structural Flexibility of Cytochromes P450?
Michal Otyepka et al.
CURRENT DRUG METABOLISM (2012)
Structural and Mechanistic Insights into the Interaction of Cytochrome P4503A4 with Bromoergocryptine, a Type I Ligand
Irina F. Sevrioukova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing
K. Vanommeslaeghe et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
OPM database and PPM web server: resources for positioning of proteins in membranes
Mikhail A. Lomize et al.
NUCLEIC ACIDS RESEARCH (2012)
Uncovering the Role of Hydrophobic Residues in Cytochrome P450-Cytochrome P450 Reductase Interactions
Cesar Kenaan et al.
BIOCHEMISTRY (2011)
Allosteric Activation of Cytochrome P450 3A4 by α-Naphthoflavone: Branch Point Regulation Revealed by Isotope Dilution Analysis
Caleb M. Woods et al.
BIOCHEMISTRY (2011)
Flexibility of human cytochrome P450 enzymes: Molecular dynamics and spectroscopy reveal important function-related variations
Tereza Hendrychova et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2011)
Hydrogen exchange mass spectrometry for studying protein structure and dynamics
Lars Konermann et al.
CHEMICAL SOCIETY REVIEWS (2011)
Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions
Michael J. Chalmers et al.
EXPERT REVIEW OF PROTEOMICS (2011)
Defining CYP3A4 Structural Responses to Substrate Binding. Raman Spectroscopic Studies of a Nanodisc-Incorporated Mammalian Cytochrome P450
Piotr J. Mak et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Conformational Analysis of Membrane Proteins in Phospholipid Bilayer Nanodiscs by Hydrogen Exchange Mass Spectrometry
Christine M. Hebling et al.
ANALYTICAL CHEMISTRY (2010)
P450cam Visits an Open Conformation in the Absence of Substrate
Young-Tae Lee et al.
BIOCHEMISTRY (2010)
Cross-linking of human cytochrome P450 2B6 to NADPH-cytochrome P450 reductase: Identification of a potential site of interaction
Namandje N. Bumpus et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2010)
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir
Irina F. Sevrioukova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Theoretical Characterization of Substrate Access/Exit Channels in the Human Cytochrome P450 3A4 Enzyme: Involvement of Phenylalanine Residues in the Gating Mechanism
Dan Fishelovitch et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2009)
Protein promiscuity and its implications for biotechnology
Irene Nobeli et al.
NATURE BIOTECHNOLOGY (2009)
Software news and updates - CHARNIM-GUI: A web-based grraphical user interface for CHARMM
Sunhwan Jo et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)
Ligand binding to cytochrome P450 3A4 in phospholipid bilayer nanodiscs - The effect of model membranes
Abhinav Nath et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W
Harshica Fernando et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)
The ins and outs of cytochrome P450s
Vlad Cojocaru et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2007)
Evaluation of the effects of hydrophilic organic solvents on CYP3A-mediated drug-drug interaction in vitro
M. Iwase et al.
HUMAN & EXPERIMENTAL TOXICOLOGY (2006)
Structural basis for ligand promiscuity in cytochrome P450 3A4
Marika Ekroos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Current views on the fundamental mechanisms of cytochrome P450 allosterism
William M. Atkins
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2006)
Structure of microsomal cytochrome P4502B4 complexed with the antifungal drug bifonazole - Insight into p450 conformational plasticity and membrane interaction
YH Zhao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Scalable molecular dynamics with NAMD
JC Phillips et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)
Structural and dynamical basis of broad substrate specificity, catalytic mechanism, and inhibition of cytochrome P450 3A4
H Park et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions
WM Atkins
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2005)
Mechanism-based inactivation of CYP3A by HIV protease inhibitors
CS Ernest et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-Å resolution
JK Yano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
PA Williams et al.
SCIENCE (2004)
Structure of mammalian cytochrome P4502B4 complexed with 4-(4-chlorophenyl) imidazole at 1.9-Å resolution -: Insight into the range of P450 conformations and the coordination of redox partner binding
EE Scott et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment
BJ Baas et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)
Pyrene-pyrene complexes at the active site of cytochrome P450 3A4: Evidence for a multiple substrate binding site
MJ Dabrowski et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)