One-Pot, Green Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by ZnFe2O4 Nanoparticles an Efficient Nanocatalyst

Zinc ferrite (ZnFe2O4) nanoparticles were synthesized in the presence of naturally available lemon juice. The synthesized zinc ferrite nanoparticles were characterized by FT-IR, XRD, SEM, TEM, TG-DTA, EDX, and BET techniques. The ZnFe2O4 is highly efficient, cheap, and reusable nanocatalyst. The zinc ferrite nanoparticles were used for the synthesis of 1H-pyrazolo[1,2-b] phthalazine-5,10-dione derivatives by one-pot coupling reaction of phthalhydrazide, aromatic aldehyde, and malononitrile under conventional reflux condition. This green synthetic approach offers important features like use of non-toxic substances, maximum yields in short reaction time, and easy purification of product.

Automated summary

In this study, zinc ferrite nanoparticles were synthesized in the presence of lemon juice and characterized using various techniques. These nanoparticles were then used as nanocatalysts for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives. This green synthetic approach offers important advantages such as the use of non-toxic substances and high yields in a short reaction time.