4.5 Article

Synthesis of gold Nanoparticles Encapsulated Chitosan/Gelatin Polymers for the Treatment of Several Types of Leukemia

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SPRINGER
DOI: 10.1007/s10904-023-02751-4

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Chitosan; Gelatin; Au NPs; Leukemia; MTT; Cytotoxicity

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In this study, we demonstrated the structural features of gold nanoparticles prepared using a biogenic template on chitosan/gelatin mixed hydrogel, and evaluated their cytotoxicity and anti-leukemia effects on various leukemia cell lines.
We herein demonstrate the biogenic nano-architechtonics of gold nanoparticles template over chitosan/gelatin mixed hydrogel having excellent reducing ability. The two biopolymers, i.e., chitosan and gelatin also had the capacity to stabilize as-synthesized Au NPs. Physicochemical and structural features of the nanocomposite biomaterial was assessed by several techniques like FT-IR, SEM, TEM, EDX and XRD. TEM study revealed the mean diameter of the spherical shaped Au NPs/CS-Gel material was in the range of 10-15 nm. Thereafter, the Au NPs/CS-Gel bio-composite material was exploited in the study of cytotoxicity and anti-leukemia effects against diverse leukemia cell lines like acute myeloid leukemia (32D-FLT3-ITD and Human HL-60/vcr), acute lymphoblastic leukemia (MOLT-3 and TALL-104), and acute T cell leukemia (Jurkat, Clone E6-1 and J.RT3-T3.5) in situ. Interestingly, the nano-drug could resist significantly against those cell lines in a time and concentration-dependent manner, assessed by MTT method. The corresponding IC50 values of the bio-composite were 341, 500, 417, 407, 389, and 500 & mu;g/mL respectively against the cell lines.

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