4.4 Article

Homocysteine metabolites inhibit autophagy, elevate amyloid beta, and induce neuropathy by impairing Phf8/H4K20me1-dependent epigenetic regulation of mTOR in cystathionine & beta;-synthase-deficient mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice

Lukasz Witucki et al.

Summary: This study demonstrates that PON1 plays a critical protective role in Alzheimer's disease by regulating mTOR signaling, autophagy, and amyloid beta accumulation.
Article Psychiatry

Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer's disease

Pratishtha Chatterjee et al.

Summary: The study found that plasma GFAP levels are elevated in cognitively normal older adults at risk of AD, indicating that astrocytic damage or activation may start from the pre-symptomatic stage of the disease and is associated with brain Aβ load. The potential of plasma GFAP to contribute to a diagnostic blood biomarker panel, along with plasma Aβ 1-42/Aβ 1-40 ratios, for cognitively normal older adults at risk of AD was highlighted by the observations from the present study.

TRANSLATIONAL PSYCHIATRY (2021)

Review Medicine, General & Internal

Homocysteine - from disease biomarker to disease prevention

A. D. Smith et al.

Summary: Elevated concentrations of plasma total homocysteine are associated with over 100 diseases or conditions, with cardiovascular diseases and diseases of the central nervous system being the most common. Lowering total homocysteine through B vitamin treatment may prevent certain diseases, indicating the clinical importance of these associations.

JOURNAL OF INTERNAL MEDICINE (2021)

Article Multidisciplinary Sciences

Serum neurofilament light levels in normal aging and their association with morphologic brain changes

Michael Khalil et al.

NATURE COMMUNICATIONS (2020)

Review Physiology

HOMOCYSTEINE MODIFICATION IN PROTEIN STRUCTURE/FUNCTION AND HUMAN DISEASE

Hieronim Jakubowski

PHYSIOLOGICAL REVIEWS (2019)

Article Multidisciplinary Sciences

Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway

Xuemei Chen et al.

NATURE COMMUNICATIONS (2018)

Article Biochemical Research Methods

Quantification of urinary S- and N-homocysteinylated protein and homocysteine-thiolactone in mice

Hieronim Jakubowski

ANALYTICAL BIOCHEMISTRY (2016)

Article Neurosciences

Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease

Sharon C Yates et al.

Acta Neuropathologica Communications (2013)

Article Multidisciplinary Sciences

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex

Philipp A. Jaeger et al.

PLOS ONE (2010)

Article Biochemistry & Molecular Biology

Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice

Hieronim Jakubowski et al.

FASEB JOURNAL (2009)

Article Genetics & Heredity

Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate

F Laumonnier et al.

JOURNAL OF MEDICAL GENETICS (2005)

Article Biochemistry & Molecular Biology

Effect of homocysteinylation of low density lipoproteins on lipid peroxidation of human endothelial cells

G Ferretti et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2004)