Visualizing Bacterial Infections With Novel Targeted Molecular Imaging Approaches

Although nearly a century has elapsed since the discovery of penicillin, bacterial infections remain a major global threat. Global antibiotic use resulted in an astounding 42 billion doses of antibiotics administered in 2015 with 128 billion annual doses expected by 2030. This overuse of antibiotics has led to the selection of multidrug-resistant super-bugs, resulting in increasing numbers of patients being susceptible to life-threatening infections with few available therapeutic options. New clinical tools are therefore urgently needed to identify bacterial infections and monitor response to antibiotics, thereby limiting overuse of antibiotics and improving overall health. Next-generation molecular imaging affords unique opportunities to target and identify bacterial infections, enabling spatial characterization as well as noninvasive, temporal monitoring of the natural course of the disease and response to therapy. These emerging noninvasive imaging approaches could overcome several limitations of current tools in infectious disease, such as the need for biological samples for testing with their associated sampling bias. Imaging of living bacteria can also reveal basic biological insights about their behavior in vivo.

Automated summary

Bacterial infections remain a major global threat even after the discovery of penicillin nearly a century ago. The overuse of antibiotics has led to the selection of multidrug-resistant super-bugs, highlighting the urgent need for new clinical tools. Next-generation molecular imaging offers unique opportunities to identify and monitor bacterial infections in a noninvasive manner, overcoming the limitations of current tools.