期刊
JOURNAL OF INFECTIOUS DISEASES
卷 -, 期 -, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiad333
关键词
gastroenteritis; replication; respiratory; rotavirus; transmission
In order to examine the potential for respiratory transmission of rotavirus, this study assessed the presence of rotavirus RNA from nasal and oropharyngeal swab specimens of Bangladeshi children with acute rotavirus gastroenteritis. The findings showed that rotavirus RNA was frequently detected in stool, oral, nasal and forehead swab specimens, indicating possible respiratory transmission. This suggests the need for further investigation.
To examine the potential for respiratory transmission of rotavirus, we systematically assessed if rotavirus RNA is detectable by real-time quantitative reverse transcription-polymerase chain reaction from nasal and oropharyngeal swab specimens of Bangladeshi children with acute rotavirus gastroenteritis. Forehead swabs were collected to assess skin contamination. Among 399 children aged <2 years hospitalized for gastroenteritis during peak rotavirus season, rotavirus RNA was detected in stool, oral, nasal and forehead swab specimens of 354 (89%). A subset was genotyped; genotype was concordant within a child's specimen set and several different genotypes were detected across children. These findings support possible respiratory transmission of rotavirus and warrant further investigation. Rotavirus RNA was frequently detected in oropharyngeal and nasal swab specimens from Bangladeshi children hospitalized with acute rotavirus gastroenteritis, supporting possible replication of rotavirus in the upper respiratory tract and respiratory transmission.
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