Metabolic dysfunction-associated steatotic liver disease (MASLD) definition is better than MAFLD criteria for lean patients with NAFLD

Article Gastroenterology & Hepatology

Special Population Lean Nonalcoholic Fatty Liver Disease

Ajay Duseja et al.

Summary: Accumulating evidence suggests that lean NAFLD is not limited to Asia but is present in different regions as well. Studies conducted in the past 20 years have provided insights into the pathogenesis, risk factors, clinical characteristics, and management of lean NAFLD. Although lean patients with NAFLD generally have milder metabolic profiles and liver diseases, some may still have NASH and advanced fibrosis, emphasizing the importance of noninvasive tests for risk stratification. A healthy lifestyle remains valuable for this unique patient population, and further research is needed to determine the best pharmacologic treatment for lean NASH.

CLINICS IN LIVER DISEASE (2023)

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Article Endocrinology & Metabolism

Lean Indian patients with non-alcoholic fatty liver disease (NAFLD) have less metabolic risk factors but similar liver disease severity as non-lean patients with NAFLD

Arka De et al.

Summary: Although most patients with NAFLD are obese or overweight, there is a subset of lean patients. This study aimed to compare the clinicopathological profile and severity of liver disease between lean and non-lean NAFLD patients.

INTERNATIONAL JOURNAL OF OBESITY (2023)

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Letter Gastroenterology & Hepatology

NAFLD vs. MAFLD - It is not the name but the disease that decides the outcome in fatty liver

Arka De et al.

JOURNAL OF HEPATOLOGY (2022)

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Review Gastroenterology & Hepatology

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review

Michelle T. Long et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can lead to serious complications and death. This article summarizes the epidemiological characteristics, prognosis, and mortality of lean individuals with NAFLD, and provides clinical practice recommendations.

GASTROENTEROLOGY (2022)

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Article Multidisciplinary Sciences

Outcomes of NAFLD and MAFLD: Results from a community-based, prospective cohort study

Madunil Anuk Niriella et al.

Summary: This study compared the impact of NAFLD and MAFLD on health outcomes and found that the risks of new-onset metabolic traits and cardiovascular events were similar between the two during a 7-year follow-up. Individuals excluded by the NAFLD definition but captured by the MAFLD definition showed a higher risk of adverse outcomes compared to those excluded by the MAFLD definition but captured by the NAFLD definition.

PLOS ONE (2021)

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Editorial Material Gastroenterology & Hepatology

Redefining non-alcoholic fatty liver disease: what's in a name?

[Anonymous]

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

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Review Gastroenterology & Hepatology

Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis

Qing Ye et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

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Metabolic dysfunction-associated steatotic liver disease (MASLD) definition is better than MAFLD criteria for lean patients with NAFLD

相关参考文献

Special Population Lean Nonalcoholic Fatty Liver Disease

Lean Indian patients with non-alcoholic fatty liver disease (NAFLD) have less metabolic risk factors but similar liver disease severity as non-lean patients with NAFLD

NAFLD vs. MAFLD - It is not the name but the disease that decides the outcome in fatty liver

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review

Outcomes of NAFLD and MAFLD: Results from a community-based, prospective cohort study

Redefining non-alcoholic fatty liver disease: what's in a name?

Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis

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