4.5 Article

Impact of age and telomere length on circulating T cells and rejection risk after lung transplantation for idiopathic pulmonary fibrosis

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Summary: This study found an enrichment of variants in telomere-maintenance genes and shorter telomeres among idiopathic pulmonary fibrosis (IPF) lung transplant recipients. However, transplant outcomes of survival and CLAD did not differ based on gene variants or telomere length in these patients. Therefore, the study supports not excluding individuals with telomere-mediated disease from lung transplantation and focusing research efforts on therapies for those with short-telomere mediated disease.

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