Cu-MOFs based photocatalyst triggered antibacterial platform for wound healing: 2D/2D Schottky junction and DFT calculation

Herein, we developed a multimodal antibacterial nanoplatform via synergism effect including knife-effect, photothermal, photocatalytic induced reactive oxygen species (ROS), and Cu2+ inherent attribute. Typically, 0.8-TC/Cu-NS possesses higher photothermal property with the higher photothermal conversion efficiency of 24% and the moderate temperature up to 97 degrees C. Meanwhile, 0.8-TC/Cu-NS exhibits the more active ROS, O-1(2) and center dot O-2(-). Hence, 0.8-TC/Cu-NS possesses best antibacterial properties against S. aureus and E. coli in vitro with efficiency of 99.94%/99.97% under near-infrared (NIR) light, respectively. In the therapeutic practical use for wound healing of Kunming mice, this system exhibits outstanding curing capacity and good biocompatibility. Based on the electron configuration measurement and density functional theory (DFT) simulation, it is confirmed that the electrons on CB of Cu-TCPP flow fleetingly to MXene trough the interface, with redistribution of charge and band upward bending over Cu-TCPP. As a result, the self-assembled 2D/2D interfacial Schottky junction have made great favor to accelerate photogenerated charges mobility, hamper charge recombination, and increases the photothermal/photocatalytic activity. This work gives us a hint to mostly design the multimodal synergistic nanoplatform under NIR light in biological applications without drug resistance.

Automated summary

In this study, a multimodal antibacterial nanoplatform was developed by utilizing a synergistic effect of knife-effect, photothermal properties, photocatalytic induced reactive oxygen species (ROS), and inherent attributes of Cu2+. The nanoplatform showed excellent antibacterial properties against S. aureus and E. coli in vitro under near-infrared (NIR) light, with efficiencies of 99.94% and 99.97%, respectively. It also exhibited outstanding curing capacity and good biocompatibility in wound healing of Kunming mice. The formation of a self-assembled 2D/2D interfacial Schottky junction facilitated the acceleration of photogenerated charges mobility, inhibition of charge recombination, and enhancement of photothermal/photocatalytic activity.