☆ 4.7 Review

Current status and issues in genomic analysis using EUS-FNA/FNB specimens in hepatobiliary-pancreatic cancers

JOURNAL OF GASTROENTEROLOGY (2023)

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Summary: This study investigated the suitability of endoscopic ultrasound-guided tissue acquisition (EUS-TA) for comprehensive genomic profiling (CGP) and found that the use of a 19G fine-needle biopsy (FNB) significantly increased the suitability for CGP analysis. The success rate of actual CGP analysis was 100% for patients who underwent the procedure.

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Summary: EUS-FNA provides better diagnostic yields and material adequacy for targeted NGS in PDAC cases, while EUS-FNB is more suitable for IHC-based biomarker testing. Concomitant use of both techniques may enhance the diagnostic process for PDAC.

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Endoscopic ultrasound (EUS)-guided fine needle biopsy alone vs. EUS-guided fine needle aspiration with rapid onsite evaluation in pancreatic lesions: a multicenter randomized trial

Yen- Chen et al.

Summary: In this study, EUS-FNB alone was found to be non-inferior to EUS-FNA+ROSE in the diagnosis of solid pancreatic lesions, with similar diagnostic accuracy for malignancy and excellent histological yield. EUS-FNB alone required fewer needle passes and shorter procedure time compared to EUS-FNA+ROSE, with comparable costs.

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Shinichi Yachida et al.

Summary: Gastrointestinal neuroendocrine carcinoma (GIS-NEC) is a rare but highly malignant tumor that is genetically distinct from gastrointestinal neuroendocrine tumors (GIS-NET). There are clear genomic differences between pancreatic NECs (Pant-NEC) and nonpancreatic GIS-NECs (Nonpanc-NEC). Panc-NECs can be classified into two subgroups based on genomic and epigenomic features.

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A Meta-Analysis Comparing Endoscopic Ultrasound-guided Fine-needle Aspiration With Endoscopic Ultrasound-guided Fine-needle Biopsy

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Summary: This study compared the diagnostic value and safety of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) in sampling solid lesions, showing that FNB has better diagnostic accuracy and tissue core rates in solid gastrointestinal lesions, with fewer needle passes, but no difference in solid pancreatic disease.

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Summary: Significant frequencies of immunotherapy biomarkers and targetable gene alterations were identified in both pancreatic cancer and biliary tract cancer, particularly in pancreatic cancer samples lacking KRAS mutations and younger populations.

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Eva Karamitopoulou

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Masaki Kuwatani et al.

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Liver biopsy technique in the era of genomic cancer therapies: a single-center retrospective analysis

Yusuke Ozeki et al.

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Proportion of unresectable pancreatic cancer specimens obtained by endoscopic ultrasound-guided tissue acquisition meeting the OncoGuide™ NCC Oncopanel System analysis suitability criteria: a single-arm, phase II clinical trial

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Effect of comprehensive cancer genomic profiling on therapeutic strategies and clinical outcomes in patients with advanced biliary tract cancer: A prospective multicenter study

Kohichi Takada et al.

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Needle Tract Seeding after Endoscopic Ultrasound Tissue Acquisition of Pancreatic Lesions: A Systematic Review and Meta-Analysis

Antonio Facciorusso et al.

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Current Clinical Practice of Precision Medicine Using Comprehensive Genomic Profiling Tests in Biliary Tract Cancer in Japan

Masashi Kanai

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Side-by-side comparison of next-generation sequencing, cytology, and histology in diagnosing locally advanced pancreatic adenocarcinoma

Silvia Carrara et al.

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Comprehensive genomic profiling for patients with chemotherapy-naive advanced cancer

Tomohiro Kondo et al.

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Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions

Kohei Fujikura et al.

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Success rate of microsatellite instability examination and complete response with pembrolizumab in biliary tract cancer

Yugo Kai et al.

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FoundationOne® CDx gene profiling in Japanese pancreatic ductal adenocarcinoma patients: a single-institution experience

Ryuichiro Kimura et al.

Summary: The study investigated the genetic mutation profiles of Japanese PDAC patients, revealing high prevalence of KRAS and TP53 mutations among the patients. The use of FoundationOne (R) CDx may be challenging for PDAC patients, as indicated by the study results, and further research with larger study populations is warranted.

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Article Gastroenterology & Hepatology

Adverse events of endoscopic ultrasound-guided fine-needle aspiration for histologic diagnosis in Japanese tertiary centers: Multicenter retrospective study

Atsushi Kanno et al.

Summary: The study revealed that adverse events related to EUS-FNA for histopathologic diagnoses were uncommon, with low incidence rates of bleeding and pancreatitis being the main concerns. Bleeding was the most common adverse event, but in most cases, blood transfusion was not required.

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Clinicogenomic Analysis of FGFR2-Rearranged Cholangiocarcinoma Identifies Correlates of Response and Mechanisms of Resistance to Pemigatinib

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Summary: The study utilized genomic profiling data to explore the genomic landscape and molecular diversity of patients with cholangiocarcinoma, as well as analyze the clinicogenomics of patients treated with pemigatinib, highlighting the utility of genomic profiling in clinical trials.

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Clinical significance of genetic alterations in endoscopically obtained pancreatic cancer specimens

Shinichi Takano et al.

Summary: Targeted sequencing of pancreatic cancer samples obtained endoscopically revealed a high detection rate of gene alterations, with factors associated with prognosis identified to help guide treatment decisions.

CANCER MEDICINE (2021)

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Josep M. Llovet et al.

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Gabriella Aitcheson et al.

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A Meta-Analysis of Slow Pull versus Suction for Endoscopic Ultrasound-Guided Tissue Acquisition

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GUT AND LIVER (2021)

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Genomic landscape of hepatocarcinogenesis

Tatsuhiro Shibata

Summary: Hepatocellular carcinoma is a global health issue, with complex genetic landscapes in the development process, particularly in precancerous lesions and advanced tumors showing intra-tumoral heterogeneity. Understanding the diverse drivers and genetic information of individual tumors has implications for optimizing treatments and early diagnosis.

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Clinical Impact of Molecular Subtyping of Pancreatic Cancer

Zhou Xu et al.

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Endoscopic tissue sampling - Part 1: Upper gastrointestinal and hepatopancreatobiliary tracts. European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Roos E. Pouw et al.

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Comparative Study of an Ultrasound-guided Percutaneous Biopsy and Endoscopic Ultrasound-guided Fine-needle Aspiration for Liver Tumors

Yuichi Takano et al.

Summary: Both percutaneous biopsy and EUS-FNA show equivalent diagnostic qualities for liver tumors, although EUS-FNA tends to be associated with fewer adverse events. A complete understanding of the characteristics of each procedure is essential when choosing the best biopsy method for each particular case.

INTERNAL MEDICINE (2021)

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Intraductal Papillary Mucinous Carcinoma Versus Conventional Pancreatic Ductal Adenocarcinoma: A Comprehensive Review of Clinical-Pathological Features, Outcomes, and Molecular Insights

Leo Mas et al.

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Reliable Detection of Somatic Mutations for Pancreatic Cancer in Endoscopic Ultrasonography-Guided Fine Needle Aspirates with Next-Generation Sequencing: Implications from a Prospective Cohort Study

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Summary: Targeted next-generation sequencing (NGS) can detect KRAS mutations from EUS-FNA samples, showing high concordance with primary tumors and ctDNA. This suggests that targeted NGS of EUS-FNA samples may enhance diagnostic accuracy in PDAC and enable preoperative ctDNA prognostication.

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Yuki Okawa et al.

Oncotarget (2021)

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Kosuke Takahashi et al.

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Ryosuke Nakatsubo et al.

Summary: This study reviewed 73 cases of pancreatic tumors that underwent EUS-FNB preoperative examination and surgery, finding a high diagnostic accuracy of 98.6% for EUS-FNB but with the risk of NTS. Caution should be exercised in considering the use of EUS-FNB in patients with resectable solid pancreatic masses.

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Endoscopic Ultrasound-Guided Fine Needle Biopsy Needles Provide Higher Diagnostic Yield Compared to Endoscopic Ultrasound-Guided Fine Needle Aspiration Needles When Sampling Solid Pancreatic Lesions: A Meta-Analysis

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Optimal number of needle passes during EUS-guided fine-needle biopsy of solid pancreatic lesions with 22G ProCore needles and different suction techniques: A randomized controlled trial

Wei Zhou et al.

Summary: This study aimed to determine the optimal number of needle passes during EUS-FNB of solid pancreatic lesions with 22G FNB needles, finding that when on-site cytological evaluation is unavailable, at least 3 passes using the SS technique are recommended, while at least 4 passes are recommended when using the SP technique. The SS technique showed potential advantages in tissue acquisition and diagnostic capabilities over the SP technique.

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Stylet Slow-pull Versus Standard Suction for Endoscopic Ultrasound-guided Fine-needle Aspiration/Biopsy of Pancreatic Solid Masses A Meta-Analysis

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GASTROINTESTINAL ENDOSCOPY (2018)

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MEDICINE (2018)

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Utility of Endoscopic Ultrasound-Guided Biopsy for Next-Generation Sequencing of Pancreatic Exocrine Malignancies

Brent K. Larson et al.

PANCREAS (2018)

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Multicenter study of early pancreatic cancer in Japan

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PANCREATOLOGY (2018)

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SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2018)

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Review Gastroenterology & Hepatology

Endoscopic retrograde cholangiopancreatography versus endoscopic ultrasound for tissue diagnosis of malignant biliary stricture: Systematic review and meta-analysis

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ENDOSCOPIC ULTRASOUND (2018)

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Meeting Abstract Oncology

The nationwide cancer genome screening project in Japan SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced gastric cancer (GC).

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JOURNAL OF CLINICAL ONCOLOGY (2018)

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Next-Generation Sequencing Using S1 Nuclease for Poor-Quality Formalin-Fixed, Paraffin-Embedded Tumor Specimens

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Genomic testing for pancreatic cancer in clinical practice as real-world evidence

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PANCREATOLOGY (2018)

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EUS-FNA versus ERCP for tissue diagnosis of suspect malignant biliary strictures: a prospective comparative study

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ENDOSCOPY INTERNATIONAL OPEN (2018)

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Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline - Updated January 2017

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ENDOSCOPY (2017)

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KRAS mutation analysis by next-generation sequencing in endoscopic ultrasound-guided sampling for solid liver masses

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Endoscopic ultrasound guided fine needle aspiration versus endoscopic ultrasound guided fine needle biopsy in sampling pancreatic masses A meta-analysis

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MEDICINE (2017)

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CANCER DISCOVERY (2017)

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Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype

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CLINICAL CANCER RESEARCH (2017)

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Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma

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Review Gastroenterology & Hepatology

A meta-analysis of endoscopic ultrasound-fine-needle aspiration compared to endoscopic ultrasound-fine-needle biopsy: diagnostic yield and the value of onsite cytopathological assessment

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ENDOSCOPY INTERNATIONAL OPEN (2017)

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Reliable Detection of Somatic Mutations in Fine Needle Aspirates of Pancreatic Cancer With Next-generation Sequencing Implications for Surgical Management

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ANNALS OF SURGERY (2016)

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Endoscopic ultrasonography with fine-needle aspiration for histological diagnosis of solid pancreatic masses: a meta-analysis of diagnostic accuracy studies

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BMC GASTROENTEROLOGY (2016)

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Biliary Cancer: Utility of Next-Generation Sequencing for Clinical Management

Milind Javle et al.

CANCER (2016)

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RNA sequencing distinguishes benign from malignant pancreatic lesions sampled by EUS-guided FNA

Sarah A. Rodriguez et al.

GASTROINTESTINAL ENDOSCOPY (2016)

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Review Gastroenterology & Hepatology

Endoscopic ultrasound-guided techniques for diagnosing pancreatic mass lesions: Can we do better?

Andrew C. Storm et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

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Diagnosis of pancreatic lesions collected by endoscopic ultrasound-guided fine-needle aspiration using next-generation sequencing

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ONCOLOGY LETTERS (2016)

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Targeted next generation sequencing of endoscopic ultrasound acquired cytology from ampullary and pancreatic adenocarcinoma has the potential to aid patient stratification for optimal therapy selection

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ONCOTARGET (2016)

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Endoscopic ultrasound-guided fine needle core biopsy for the diagnosis of pancreatic malignant lesions: a systematic review and Meta-Analysis

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SCIENTIFIC REPORTS (2016)

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The Nationwide Cancer Genome Screening Project in Japan, SCRUM-Japan GI-SCREEN: Efficient identification of cancer genome alterations in advanced colorectal cancer.

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NATURE GENETICS (2015)

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Comparison of 22G reverse-beveled versus standard needle for endoscopic ultrasound-guided sampling of solid pancreatic lesions

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UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2015)

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CTNNB1 mutational analysis of solid-pseudopapillary neoplasms of the pancreas using endoscopic ultrasound-guided fine-needle aspiration and next-generation deep sequencing

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Endoscopic ultrasound-guided fine-needle biopsy of small solid pancreatic lesions using a 22-gauge needle with side fenestration

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SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2015)

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Clinical utility of circulating tumor DNA for molecular assessment in pancreatic cancer

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SCIENTIFIC REPORTS (2015)

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K-ras Mutational Status in Cytohistological Tissue as a Molecular Marker for the Diagnosis of Pancreatic Cancer: A Systematic Review and Meta-Analysis

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DISEASE MARKERS (2014)

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Review Gastroenterology & Hepatology

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GASTROINTESTINAL ENDOSCOPY (2014)

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Clinical Next-Generation Sequencing Successfully Applied to Fine-Needle Aspirations of Pulmonary and Pancreatic Neoplasms

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CANCER CYTOPATHOLOGY (2013)

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The diagnostic accuracy of 22-gauge and 25-gauge needles in endoscopic ultrasound-guided fine needle aspiration of solid pancreatic lesions: a meta-analysis

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ENDOSCOPY (2013)

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Review Gastroenterology & Hepatology

How Good Is Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Diagnosing the Correct Etiology for a Solid Pancreatic Mass? A Meta-Analysis and Systematic Review

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PANCREAS (2013)

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Assessment of morbidity and mortality associated with EUS-guided FNA: a systematic review

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GASTROINTESTINAL ENDOSCOPY (2011)

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Endoscopic retrograde cholangiography versus peroral cholangioscopy to evaluate intraepithelial tumor spread in biliary cancer

H. Kawakami et al.

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