☆ 4.5 Article

Study on the Potential Mechanism of Traditional Marine Chinese Medicine Beishashen in Preventing Lung Injury Induced by Radiotherapy and Chemotherapy

JOURNAL OF FOOD BIOCHEMISTRY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Amomum subulatum mitigates experimental thoracic radiation-induced lung injury by regulating antioxidant status and inflammatory responses

Sudarsanan Drishya et al.

Summary: This study investigates the potential of the culinary spice Amomum subulatum in mitigating radiation-induced lung injury. The results show that the methanolic extract of A. subulatum dry fruits can reduce oxidative stress, inflammation, and fibrosis in the lungs caused by radiation therapy. The study suggests that A. subulatum could be a potential nutraceutical therapy for radiation-induced lung injury.

FOOD & FUNCTION (2023)

添加到收藏夹

Article Biology

Molecular mechanism of Ferula asafoetida for the treatment of asthma: Network pharmacology and molecular docking approach

Muhammad Qasim et al.

Summary: Asthma is a challenging and costly health issue, and the therapeutic efficacy of Ferula asafoetida in treating asthma is yet to be fully understood. This study used network pharmacology and molecular docking to identify the bioactive compounds of F. asafoetida and reveal its mechanism in preventing asthma.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2023)

添加到收藏夹

Article Environmental Sciences

Protective effect of quercetin on pulmonary dysfunction in streptozotocin-induced diabetic rats via inhibition of NLRP3 signaling pathway

Noha Osama El-Shaer et al.

Summary: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia, and NLRP3-mediated pyroptosis may contribute to the development of diabetic complications. Quercetin, a natural flavonoid, has been reported to have antioxidant effects on different tissues, but its effects on NLRP3-mediated pyroptosis in diabetic lung are unclear. This study aimed to evaluate the protective effects of quercetin on lung function, oxidative stress, and NLRP3-mediated pyroptosis in Wister rats with STZ-induced DM.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023)

添加到收藏夹

Article Medicine, Research & Experimental

Amifostine analog, DRDE-30, alleviates radiation induced lung damage by attenuating inflammation and fibrosis

Aastha Arora et al.

Summary: DRDE-30 could be a potential prophylactic agent against radiation-induced lung injury, improving survival rate, reducing inflammation, decreasing lung fibrosis, and attenuating tissue damage.

LIFE SCIENCES (2022)

添加到收藏夹

Article Plant Sciences

Quercetin-3-Rutinoside alleviates radiation-induced lung inflammation and fibrosis via regulation of NF-ΚB/TGF-β1 signaling

Savita Verma et al.

Summary: The study found that Quercetin-3-Rutinoside (Q-3-R) can protect against radiation-induced lung injury by regulating NF-Kappa B/TGF-beta 1 signaling pathway, scavenging free radicals, preventing perivascular infiltration, and prolonged inflammatory cascade. This may have potential therapeutic effects on lung damage caused by planned or unplanned radiation exposure.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

The TCM Preparation Feilike Mixture for the Treatment of Pneumonia: Network Analysis, Pharmacological Assessment and Silico Simulation

Juqin Peng et al.

Summary: The Feilike mixture (FLKM) was found to improve clinical symptoms, regulate immune inflammation response, and ameliorate pulmonary function in pneumonia treatment. Various active components interacted with pneumonia-related targets, mainly enriched in immune-related pathways. In vivo experiments showed that FLKM reduced lung injury and neutrophil infiltration in rats with pneumonia. Molecular docking tests revealed tight binding between active compounds and targeted proteins. This study identified core compositions and targets for FLKM in pneumonia treatment and provided pharmacological evidence supporting its clinical efficacy.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Article Cell Biology

Antitumor Effects of Ononin by Modulation of Apoptosis in Non-Small-Cell Lung Cancer through Inhibiting PI3K/Akt/mTOR Pathway

Guowei Gong et al.

Summary: Lung cancer is a major cause of cancer-related death globally for both men and women. Non-small-cell lung cancer (NSCLC), which is difficult to control with conventional therapy, has a poor prognosis. This study found that ononin, an isoflavone glycoside extracted from Astragali Radix, can inhibit NSCLC progression and promote apoptosis when combined with paclitaxel (PTX). The combination treatment showed enhanced antitumor effects by inhibiting cell proliferation through the PI3K/Akt/mTOR signaling pathways and reducing PTX-induced liver and kidney damage.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Redox Interactions in Chemo/Radiation Therapy-induced Lung Toxicity; Mechanisms and Therapy Perspectives

Xixi Lai et al.

Summary: Lung toxicity is a major limitation for cancer therapy, with radiotherapy and chemotherapy causing lung injury through the production of reactive oxygen species and nitric oxide. This review explores the cellular and molecular mechanisms of redox-induced lung injury and suggests potential targets and perspectives to mitigate lung toxicity.

CURRENT DRUG TARGETS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Exploring the role of Xingren on COVID-19 based on network pharmacology and molecular docking

Maoru Wang et al.

Summary: This study used network pharmacology and molecular docking to explore the potential mechanism and important targets of Almonds (Xingren) in the prevention and treatment of COVID-19. It found that licochalcone B and PTGS2 may play important roles and provided a theoretical basis and reference for the development of new drugs.

JOURNAL OF FOOD BIOCHEMISTRY (2022)

添加到收藏夹

Article Plant Sciences

Re-Du-Ning injection ameliorates radiation-induced pneumonitis and fibrosis by inhibiting AIM2 inflammasome and epithelial-mesenchymal transition

Chenxi Yang et al.

Summary: The study found that Re-Du-Ning (RDN) injection can effectively alleviate radiation-induced lung injury (RILI) by inhibiting AIM2-mediated pyroptosis and suppressing the epithelial-mesenchymal transition (EMT) pathway to improve radiation pneumonitis (RP).

PHYTOMEDICINE (2022)

添加到收藏夹

Article Oncology

Prediction of the Mechanism of Sodium Butyrate against Radiation-Induced Lung Injury in Non-Small Cell Lung Cancer Based on Network Pharmacology and Molecular Dynamic Simulations and Molecular Dynamic Simulations

Xiao-zhen Zhang et al.

Summary: This study aimed to investigate the protective mechanisms of sodium butyrate (NaB) against radiation-induced lung injury (RILI) in non-small cell lung cancer (NSCLC) through network pharmacology, molecular docking, molecular dynamic simulations, and in vivo experiments. The results revealed that NaB may protect patients from RILI through multiple target genes including AKT1, TP53, NOTCH1, SIRT1, and PTEN, with multiple signaling pathways involving PI3K-Akt pathway, p53 pathway, and FOXO pathways. The findings provide a theoretical basis to further understand the mechanism of NaB in the treatment of RILI.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Review Oncology

Functional lung imaging in thoracic tumor radiotherapy: Application and progress

Pi-Xiao Zhou et al.

Summary: Radiotherapy plays a crucial role in thoracic tumor treatment, but radiation-induced lung injury limits the increase in target doses. The introduction of functional lung imaging allows for the design of a functional lung protection plan, reducing the impact of radiation on functional lung and decreasing the occurrence of radiation-induced lung injury.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Article Chemistry, Medicinal

Candesartan Attenuates Cisplatin-Induced Lung Injury by Modulating Oxidative Stress, Inflammation, and TLR-4/NF-κB, JAK1/STAT3, and Nrf2/HO-1 Signaling

Ahmed M. Atwa et al.

Summary: This study found that candesartan can prevent oxidative stress, inflammation, and lung injury induced by cisplatin. Candesartan can suppress the activity of TLR-4/NF-κB and JAK1/STAT3 signaling pathways, alleviating cisplatin-induced oxidative stress and inflammation.

PHARMACEUTICALS (2022)

添加到收藏夹

Article Plant Sciences

Re-Du-Ning injection ameliorates radiation-induced pneumonitis and fibrosis by inhibiting AIM2 inflammasome and epithelial-mesenchymal transition

Chenxi Yang et al.

Summary: The study found that RDN injection can significantly alleviate radiation-induced lung injury by inhibiting inflammatory cell infiltration and the expression of inflammatory cytokines. The potential mechanisms of RDN in ameliorating radiation pneumonitis were also predicted, including the inhibition of AIM2-mediated pyroptosis and EMT.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Review Nanoscience & Nanotechnology

Nanomedicine-Based Therapeutics to Combat Acute Lung Injury

Shuai Bian et al.

Summary: ALI and ARDS can cause life-threatening respiratory failure with a high mortality rate. Despite some clinical interventions, there is still no completely effective treatment for ALI. Recent advances in nanotechnology may provide new possibilities for the pharmacotherapy of ALI.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

添加到收藏夹

Article Oncology

Neoadjuvant Concurrent Radiotherapy and Chemotherapy in Early Breast Cancer Patients: Long-Term Results of a Prospective Phase II Trial

Diane Jornet et al.

Summary: This prospective study showed that combining radiation therapy and chemotherapy can increase breast conservation rate and allow for one-stage breast reconstructive surgery in breast cancer treatment. Long-term follow-up demonstrated high local control rates with limited side-effects.

CANCERS (2021)

添加到收藏夹

Review Plant Sciences

Aidi injection as adjunctive treatment to gemcitabine-based chemotherapy for advanced non-small cell lung cancer: a systematic review and meta-analysis

Sitong Guo et al.

Summary: The study included 54 RCTs with 4318 NSCLC patients, indicating that Aidi injection combined with GBC significantly improved efficacy and quality of life, while reducing toxicities.

PHARMACEUTICAL BIOLOGY (2021)

添加到收藏夹

Article Oncology

Grape Seed Proanthocyanidins play the roles of radioprotection on Normal Lung and radiosensitization on Lung Cancer via differential regulation of the MAPK Signaling Pathway

Yang Xu et al.

Summary: The study found that grape seed proanthocyanidins have radioprotective effects on normal lung and radiosensitizing effects on lung cancer cells, enhancing the killing effect of radiotherapy. These two-way effects may be related to the regulation of the MAPK signaling pathway by GSP.

JOURNAL OF CANCER (2021)

添加到收藏夹

Article Immunology

Quercetin, a pneumolysin inhibitor, protects mice against Streptococcus pneumoniae infection

Qianghua Lv et al.

MICROBIAL PATHOGENESIS (2020)

添加到收藏夹

Article Respiratory System

Quercetin Attenuates Acute Lung Injury Caused by Cigarette Smoke Both In Vitro and In Vivo

Natalia Pereira da Silva Araujo et al.

COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2020)

添加到收藏夹

Article Integrative & Complementary Medicine

Mechanism of Dayuanyin in the treatment of coronavirus disease 2019 based on network pharmacology and molecular docking

Xiaofeng Ruan et al.

CHINESE MEDICINE (2020)

添加到收藏夹

Article Oncology

Candidate genes and potential mechanisms for chemoradiotherapy sensitivity in locally advanced rectal cancer

Chunsheng Li et al.

ONCOLOGY LETTERS (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1/Th2 Imbalance in RP Rats

Yuan Yang et al.

BIOMED RESEARCH INTERNATIONAL (2019)

添加到收藏夹

Article Food Science & Technology

Quercetin attenuates the hyperoxic lung injury in neonatal mice: Implications for Bronchopulmonary dysplasia (BPD)

Paramahamsa Maturu et al.

FOOD AND CHEMICAL TOXICOLOGY (2018)

添加到收藏夹

Article Cell Biology

Protective Effect of Quercetin in LPS-Induced Murine Acute Lung Injury Mediated by cAMP-Epac Pathway

Xue-feng Wang et al.

INFLAMMATION (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Anticancer activity of polysaccharide from Glehnia littoralis on human lung cancer cell line A549

Jun Wu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Alveolar Micromechanics in Bleomycin-induced Lung Injury

Lars Knudsen et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

添加到收藏夹

Article Medicine, General & Internal

Pretreated Glehnia littoralis Extract Prevents Neuronal Death Following Transient Global Cerebral Ischemia through Increases of Superoxide Dismutase 1 and Brain-derived Neurotrophic Factor Expressions in the Gerbil Hippocampal Cornu Ammonis 1 Area

Joon Ha Park et al.

CHINESE MEDICAL JOURNAL (2017)

添加到收藏夹

Article Oncology

Genetic variants in PI3K/AKT pathway are associated with severe radiation pneumonitis in lung cancer patients treated with radiation therapy

Yang Tang et al.

CANCER MEDICINE (2016)

添加到收藏夹

Article Cell Biology

Protective Effects of Myrtol Standardized Against Radiation-Induced Lung Injury

De-yun Zhao et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)

添加到收藏夹

Article Pathology

Inhibition of endogenous glucocorticoid synthesis aggravates lung injury triggered by septic shock in rats

Erika K. Incerpi et al.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2015)

添加到收藏夹

Article Integrative & Complementary Medicine

Authentication of commercial processed Glehniae Radix (Beishashen) by DNA barcodes

Xunzhi Zhu et al.

CHINESE MEDICINE (2015)

添加到收藏夹

Review Radiology, Nuclear Medicine & Medical Imaging

New era of radiotherapy: An update in radiation-induced lung disease

M. F. K. Benveniste et al.

CLINICAL RADIOLOGY (2013)

添加到收藏夹

Article Oncology

Postmastectomy Hypofractionated and Accelerated Radiation Therapy With (and Without) Subcutaneous Amifostine Cytoprotection

Michael I. Koukourakis et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2013)

添加到收藏夹

Article Oncology

Quercetin liposomes protect against radiation-induced pulmonary injury in a murine model

Hao Liu et al.

ONCOLOGY LETTERS (2013)

添加到收藏夹

Article Immunology

Anti-inflammatory effects of Glehnia littoralis extract in acute and chronic cutaneous inflammation

Taesook Yoon et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2010)

添加到收藏夹

Article Medicine, Research & Experimental

Protective effect of quercetin against paraquat-induced lung injury in rats

Hee K. Park et al.

LIFE SCIENCES (2010)

添加到收藏夹

Article Oncology

American Society of Clinical Oncology 2008 Clinical Practice Guideline Update: Use of Chemotherapy and Radiation Therapy Protectants

Martee L. Hensley et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

添加到收藏夹

Article Respiratory System

Efeitos da quercetina na lesão pulmonar induzida por bleomicina: um estudo preliminar

José Antônio Baddini Martinez et al.

Jornal Brasileiro de Pneumologia (2008)

添加到收藏夹

Article Critical Care Medicine

All-trans-retinoic acid prevents radiation- or bleomycin-induced pulmonary fibrosis

Chiharu Tabata et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.