☆ 4.4 Article

Practical Characterization Strategies for Comparison, Qualification, and Selection of Cell Viability Detection Methods for Cellular Therapeutic Product Development and Manufacturing

JOURNAL OF FLUORESCENCE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Chemistry, Multidisciplinary

Combinatorial physical methods for cellular therapy: Towards the future of cellular analysis?

Pulasta Chakrabarty et al.

Summary: The physical energy activated techniques for cellular delivery and analysis is a rapidly expanding research area in biological and biomedical studies. These techniques have been widely used for delivering biomolecules into different cell types, but individual methods have limitations. Recent studies have combined different membrane disruption techniques, resulting in enhanced transfection, lower delivery parameters, and high cell viability. These studies open up new avenues for understanding subcellular structure and developing novel therapeutic strategies.

JOURNAL OF CONTROLLED RELEASE (2023)

添加到收藏夹

Article Cell Biology

Comparison of Radiation Response between 2D and 3D Cell Culture Models of Different Human Cancer Cell Lines

Julia Raitanen et al.

Summary: Radiation therapy is an effective tool in cancer treatment, but its success rate varies. A study compared the radiation responses of 2D and 3D cell culture models of different human cancer cell lines. The results showed significant differences in radiation sensitivity between the two models, with 3D spheroids exhibiting higher resistance to radiation.

CELLS (2023)

添加到收藏夹

Review Engineering, Biomedical

Challenges in the clinical advancement of cell therapies for Parkinson's disease

Sophie Skidmore et al.

Summary: Cell therapies have shown potential as treatments for Parkinson's disease since the 1980s, but have faced challenges due to poor standardization and ethical constraints. Recent advances in stem-cell technologies and understanding of dopaminergic neuron development have enabled progress in preclinical studies. However, further work is needed to ensure safety screening, optimize cell products, and scale up manufacturing for clinical use.

NATURE BIOMEDICAL ENGINEERING (2023)

添加到收藏夹

Review Oncology

Chimeric Antigen Receptor T-Cell Therapy Current Perspective on T Cell-Intrinsic, T Cell-Extrinsic, and Therapeutic Limitations

Shawna K. K. Brookens et al.

Summary: Genetically engineered CAR T-cell therapy makes use of the immune system to eliminate tumors and redirect cytotoxic functions towards cells expressing specific tumor-restricted antigens. Despite FDA approval for 6 CAR T-cell therapies in hematological malignancies, there are limitations in the treatment of both liquid and solid tumors involving T cell-intrinsic, T cell-extrinsic, and therapeutic factors. This review discusses the core structure of CAR, the evolution of different CAR generations, limitations of CAR T-cell therapy, and current strategies to overcome barriers for successful therapy.

CANCER JOURNAL (2023)

添加到收藏夹

Article Biochemical Research Methods

Cross-platform immunophenotyping of human peripheral blood mononuclear cells with four high-dimensional flow cytometry panels

Alexander Heubeck et al.

Summary: This article highlights the importance of immunophenotyping using high dimensional flow cytometry and presents four high parameter flow cytometry panels for deep immunophenotyping of human PBMC. These panels include 64 cell surface markers and provide insights into immune compartment populations. The panels were developed using two different cytometers and produced comparable high quality flow cytometry data, demonstrating their suitability for immune profiling experiments.

CYTOMETRY PART A (2023)

添加到收藏夹

Article Oncology

Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor- Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors

Sanghyun P. Kim et al.

Summary: Adoptive cellular therapy (ACT) targeting TP53 mutations shared among different cancer types shows durable clinical responses, but limited efficacy. A library of 39 T-cell receptors (TCRs) targeting shared TP53 mutations in 7.3% of solid tumor patients was reported. Treatment with ex vivo-expanded autologous tumor-infiltrating lymphocytes (TILs) or autologous peripheral blood lymphocytes transduced with an allogeneic HLA-A*02-restricted TCR specific for p53R175H showed improved efficacy.

CANCER IMMUNOLOGY RESEARCH (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Observation and quantification of the morphological effect of trypan blue rupturing dead or dying cells

Leo Li-Ying Chan et al.

PLOS ONE (2020)

添加到收藏夹

Article Oncology

Synergistic Effects of Nobiletin and Sorafenib Combination on Metastatic Prostate Cancer Cells

Gamze Guney Eskiler et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2019)

添加到收藏夹

Review Oncology

Acridine Orange: A Review of Nove Applications for Surgical Cancer Imaging and Therapy

Vadim A. Byvaltsev et al.

FRONTIERS IN ONCOLOGY (2019)

添加到收藏夹

Review Endocrinology & Metabolism

Starvation, Stress Resistance, and Cancer

Roberta Buono et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Dual direction CRISPR transcriptional regulation screening uncovers gene networks driving drug resistance

Carlos le Sage et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Oncology

Bladder cancer cells re-educate TAMs through lactate shuttling in the microfluidic cancer microenvironment

Yang Zhao et al.

ONCOTARGET (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Morphological observation and analysis using automated image cytometry for the comparison of trypan blue and fluorescence-based viability detection method

Leo Li-Ying Chan et al.

CYTOTECHNOLOGY (2015)

添加到收藏夹

Article Biochemical Research Methods

Evaluation of Acridine Orange, LysoTracker Red, and Quinacrine as Fluorescent Probes for Long-Term Tracking of Acidic Vesicles

Agnieszka Pierzynska-Mach et al.

CYTOMETRY PART A (2014)

添加到收藏夹

Article Biochemical Research Methods

Accurate measurement of peripheral blood mononuclear cell concentration using image cytometry to eliminate RBC-induced counting error

Leo Li-Ying Chan et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2013)

添加到收藏夹

Article Biochemical Research Methods

Rapid Image-based Cytometry for Comparison of Fluorescent Viability Staining Methods

Leo L. Chan et al.

JOURNAL OF FLUORESCENCE (2012)

添加到收藏夹

Article Physics, Applied

Dose-dependent killing of leukemia cells by low-temperature plasma

N. Barekzi et al.

JOURNAL OF PHYSICS D-APPLIED PHYSICS (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

UV Light Killing Efficacy of Fluorescent Protein-Expressing Cancer Cells In Vitro and In Vivo

Hiroaki Kimura et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2010)

添加到收藏夹

Review Biochemistry & Molecular Biology

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

G. Kroemer et al.

CELL DEATH AND DIFFERENTIATION (2009)

添加到收藏夹

Article Engineering, Chemical

Fluorochrome and fluorescent in situ hybridization to monitor bioaerosols in swine buildings

MC Chi et al.

AEROSOL SCIENCE AND TECHNOLOGY (2005)

添加到收藏夹

Article Physics, Fluids & Plasmas

The effects of UV irradiation and gas plasma treatment on living mammalian cells and bacteria: A comparative approach

EA Sosnin et al.

IEEE TRANSACTIONS ON PLASMA SCIENCE (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.