Advances in autophagy modulation of natural products in cervical cancer

Review Biochemistry & Molecular Biology

Therapeutic Effects of Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis

Daniela Mokra et al.

Summary: （

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Biochemistry & Molecular Biology

Apigenin: A Therapeutic Agent for Treatment of Skin Inflammatory Diseases and Cancer

Ji Hye Yoon et al.

Summary: The skin acts as a protective barrier against external factors and prevents the entry of harmful agents into the body. Skin diseases can occur when there is an overreactive response to these agents. Apigenin, a flavonoid compound, has shown potential in reducing skin inflammation by targeting inflammatory markers and molecular pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Oncology

Image Guidance Volume-Modulated Arc Radiation Therapy Concurrently With Nab-Paclitaxel Plus Cisplatin for Patients With Locally Advanced Cervical Cancer: A Single-Arm Dose Escalation Trial

Ping Jiang et al.

Summary: The purpose of this study was to determine the maximal tolerated dose (MTD) and dose-limiting toxicity (DLT) of nab-paclitaxel plus cisplatin for locally advanced cervical cancer (LACC) using image guidance volume modulated arc therapy. The study found that the MTD of nab-paclitaxel was 50 mg/m2 and the complete response rate was 90.9%.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2023)

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Article Biochemistry & Molecular Biology

Natural Products from Leaves of the Ancient Iranian Medicinal Plant Echium amoenum Fisch. & C. A. Mey.

Mehdi Jafari Jamnani et al.

Summary: Echium amoenum leaves, an Iranian medicinal plant, have been used as tea for treating inflammation and other conditions. The nutritional value of E. amoenum tea is mainly due to its high content of water-soluble antioxidants. Previous research focused on natural products from E. amoenum flowers.

MOLECULES (2023)

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Article Oncology

Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results of the phase II PRIMMO study

Emiel A. De Jaeghere et al.

Summary: The PRIMMO study conducted a phase II trial on patients with pretreated persistent/recurrent/metastatic cervical or endometrial cancer. The study found that pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail had modest but durable antitumor activity, with acceptable but not negligible toxicity.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2023)

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Review Nutrition & Dietetics

Pharmacological and Molecular Insight on the Cardioprotective Role of Apigenin

Shilu Deepa Thomas et al.

Summary: Apigenin, a dietary flavonoid, has antioxidant, anti-inflammatory, anticancer, and antibacterial properties. It has shown potential therapeutic effects in the treatment of cardiovascular diseases such as atherosclerosis, stroke, hypertension, myocardial injury, and diabetic cardiomyopathy. This review focuses on the pharmacological mechanisms, therapeutic uses, and potential applications of apigenin in the treatment of cardiovascular disorders. Further research is needed to establish its safety and efficacy and explore its potential as a nutraceutical and therapeutic agent.

NUTRIENTS (2023)

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Review Medicine, Research & Experimental

Unraveling the therapeutic potential of natural products in the prevention and treatment of leukemia

Harsh Goel et al.

Summary: Leukemia is a heterogeneous group of hematological malignancies characterized by differentiation blockage and uncontrolled proliferation of myeloid or lymphoid progenitor cells. Traditional treatments such as chemotherapy and stem cell transplantation have severe side effects and drug resistance. Therefore, it is essential to develop novel therapeutic approaches using natural products, which have diverse bioactive compounds and have been proven to destroy leukemia cells through various mechanisms of action.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Review Medicine, Research & Experimental

Astragaloside IV: A promising natural neuroprotective agent for neurological disorders

Min Yao et al.

Summary: Neurological disorders pose a serious threat to human health, but effective treatment options are currently lacking. Chinese herbal medicine, particularly Astragali Radix, has shown promise in preventing and treating neurological disorders. Previous research suggests that astragaloside IV, found in Astragali Radix, may have neuroprotective effects through various mechanisms such as anti-inflammatory, anti-oxidative, and anti-apoptotic actions, as well as nerve regeneration promotion. Astragaloside IV has the potential to be a new natural neuroprotective agent for the treatment of neurological disorders.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Review Chemistry, Medicinal

A comprehensive review of emodin in fibrosis treatment

Xinhua Jia et al.

Summary: Emodin, the main active component of rhubarb, has significant pharmacological effects and clinical efficacy. It has various therapeutic effects, such as anti-cancer and anti-fibrosis effects, and is commonly used for the treatment of encephalitis, diabetic cataract, and organ fibrosis. However, the mechanism of emodin in fibrosis treatment is complex and the evidence from some studies is conflicting. This paper reviews the mechanisms, pharmacokinetics, and toxicology of emodin in fibrosis treatment, and briefly discusses new formulations to improve its efficacy, providing a reference for future studies.

FITOTERAPIA (2023)

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Article Obstetrics & Gynecology

Final survival analysis of topotecan and paclitaxel for first-line treatment of advanced cervical cancer: An NRG oncology randomized study

Krishnansu S. Tewari et al.

GYNECOLOGIC ONCOLOGY (2023)

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Article Toxicology

Plumbagin downregulates UHRF1, p-Akt, MMP-2 and suppresses survival, growth and migration of cervical cancer CaSki cells

Harsimran Sidhu et al.

Summary: This study reveals that plumbagin inhibits the growth of cervical cancer cells by inducing apoptosis, inhibiting migration, and affecting the expression of specific proteins. Plumbagin also shows synergy with cisplatin, enhancing its anticancer effect.

TOXICOLOGY IN VITRO (2023)

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Review Cell Biology

Role of autophagy in aging: The good, the bad, and the ugly

Siamak Tabibzadeh

Summary: Autophagy is a crucial process for maintaining cellular metabolic demands and preventing aging, disease, and cancer. Genetic defects in autophagy genes and age-induced decline of autophagy can lead to various abnormalities and loss of cellular control.

AGING CELL (2023)

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Review Biochemistry & Molecular Biology

Enhancing Anti-Cancer Therapy with Selective Autophagy Inhibitors by Targeting Protective Autophagy

Min Ju Lee et al.

Summary: Autophagy is a process that maintains intracellular homeostasis by eliminating damaged or unnecessary proteins and organelles. Deregulation of autophagy is associated with various diseases, including cancer. The cytoprotective mechanism of autophagy has been extensively studied for overcoming resistance to cancer therapies, leading to the development of selective autophagy inhibitors for cancer treatment.

BIOMOLECULES & THERAPEUTICS (2023)

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Review Biotechnology & Applied Microbiology

Ursolic acid: a pentacyclic triterpenoid that exhibits anticancer therapeutic potential by modulating multiple oncogenic targets

Sardul Singh Sandhu et al.

Summary: The world is currently facing a global challenge against neoplastic diseases. Current research has focused on phytochemical compounds isolated from plants to treat deadly cancers. Ursolic acid (UA) and its derivative compounds have shown promising anticancer properties, including inhibiting cancer cell viability, preventing tumor angiogenesis, and regulating various cellular processes.

BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS (2023)

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Review Oncology

Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance

Wai-Jo Jocelin Chan et al.

Summary: Natural products, such as dietary supplements and health supplements, are commonly used by cancer patients to improve quality of life and reduce treatment side effects. However, there is concern that the concurrent use of these products with cancer treatments can lead to adverse effects and unintended treatment outcomes. Limited research suggests that some natural products may interact with common cancer treatments, while others may actually reduce side effects. Further investigation is needed in this area.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2023)

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Article Biochemistry & Molecular Biology

The cGAS-STING pathway: a therapeutic target in chromosomally unstable cancers

Haiyan Yan et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

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Review Cell Biology

The role of autophagy in viral infections

Tong Chen et al.

Summary: Autophagy is a cellular process that degrades virus particles and components during a viral infection. However, viruses have evolved various strategies to subvert autophagy and counteract cellular antiviral responses.

JOURNAL OF BIOMEDICAL SCIENCE (2023)

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Review Biochemistry & Molecular Biology

Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets

Feng Shu et al.

Summary: Autophagy has multifaceted physiological effects, acting as a protective mechanism against diseases while also having detrimental effects on normal cells. The dysregulation of autophagy-related regulators and proteins can lead to imbalanced autophagy flux, and epigenetic and post-translational modifications play a role in this process. Understanding the regulatory mechanisms of autophagy and its impact on therapeutic effectiveness is important for the development of potential targets for disease treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

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Article Oncology

Matrine exerts antitumor activity in cervical cancer by protective autophagy via the Akt/mTOR pathway in vitro and in vivo

Fan Zhang et al.

Summary: This study showed that matrine can inhibit the proliferation of cervical cancer cells and induce autophagy by inhibiting the Akt/mTOR signaling pathway. Additionally, the combination of matrine and cisplatin was more effective in suppressing the proliferation of cervical cancer cells both in vitro and in vivo.

ONCOLOGY LETTERS (2022)

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Article Chemistry, Medicinal

Overexpression of ARHI increases the sensitivity of cervical cancer cells to paclitaxel through inducing apoptosis and autophagy

Yang Wang et al.

Summary: This study investigated the role of ARHI in cervical cancer and found that high expression of ARHI can decrease MDR1 expression, promote apoptosis and activate autophagy, thus increasing sensitivity to paclitaxel in a pathway dependent on AKT/mTOR inactivation.

DRUG DEVELOPMENT RESEARCH (2022)

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Review Genetics & Heredity

Current and future direction in treatment of HPV-related cervical disease

Niloofar Khairkhah et al.

Summary: This review provides a detailed overview of the current treatment options for HPV-related cervical precancerous and cancerous diseases, including therapeutic vaccines and the use of genome-editing CRISPR/Cas system. Although the development of vaccines has been slow, recent trials have shown promising results.

JOURNAL OF MOLECULAR MEDICINE-JMM (2022)

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Review Pharmacology & Pharmacy

Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases

Erika Plazas et al.

Summary: Complex diseases such as neurodegenerative disorders and cancer pose a significant public health problem. The traditional pharmacotherapy based on a single target has been insufficient, and the emerging multi-target approach shows promise in the search for new drug candidates. Plant-derived isoquinoline alkaloids offer a vast source of multimodal agents with unique structural diversity and a wide range of pharmacological activities. This review provides a comprehensive compilation of the pharmacological relevance and multi-target potential of natural isoquinolines, emphasizing their promising activity in complex diseases.

PHARMACOLOGICAL RESEARCH (2022)

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Article Oncology

Punicalagin promotes autophagic degradation of human papillomavirus E6 and E7 proteins in cervical cancer through the ROS-JNK-BCL2 pathway

Xialin Xie et al.

Summary: This study revealed that punicalagin downregulates the levels of HPV oncoproteins E6 and E7 in cervical cancer cells through the autophagy-lysosome system. It activates the ROS-JNK pathway and induces autophagy. The degradation of E6 and E7 by punicalagin depends on autophagy. In vivo studies demonstrate that punicalagin efficiently inhibits cervical cancer growth.

TRANSLATIONAL ONCOLOGY (2022)

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Review Biotechnology & Applied Microbiology

Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine

Rui Sun et al.

Summary: Triptolide (TP) is a natural product with various biological activities, but its narrow therapeutic window, poor water solubility, and fast metabolism limit its clinical application. To overcome these limitations, targeted drug delivery systems (TDDS) based on nanomaterials have been developed. This review summarizes recent studies on TDDS combined with TP, highlighting the potential of TDDS as a multifunctional and efficient method for delivering TP.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Nutrition & Dietetics

Potential Role of Ginger (Zingiber officinale Roscoe) in the Prevention of Neurodegenerative Diseases

Raul Arcusa et al.

Summary: Ginger is a plant that contains multiple bioactive compounds, including gingerol and shogaol, which have antioxidant, anti-inflammatory, and potentially neuroprotective effects. These compounds may improve symptoms and pathological conditions of neurodegenerative diseases by modulating cell death or cell survival signaling molecules.

FRONTIERS IN NUTRITION (2022)

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Review Biochemistry & Molecular Biology

Ursolic Acid Analogs as Potential Therapeutics for Cancer

Siva S. Panda et al.

Summary: Ursolic acid (UA) is a pentacyclic triterpene with diverse pharmacological properties, including anti-inflammatory, antimicrobial, antiviral, antioxidant, and anti-proliferative activities. It holds promise as a cancer preventive and therapeutic agent due to its relatively non-toxic properties against normal cells but its activities against cancer cells. However, its low bioavailability limits its clinical applications. Researchers have been designing and developing synthetic analogs of UA to overcome this limitation and utilize its importance.

MOLECULES (2022)

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Article Biophysics

A cationic amino acid polymer nanocarrier synthesized in supercritical CO2 for co-delivery of drug and gene to cervical cancer cells

K. V. Kavya et al.

Summary: This study explores the ability of a drug-loaded polymer to inhibit cervical cancer cells. The results show that the polymer treatment activates cell death mechanisms and disrupts the cell membrane. Further experiments demonstrate that the polymer treatment effectively suppresses a protein and simulates a cellular pathway. This combination therapy approach has the potential to enhance treatment efficacy and overcome chemosensitivity issues.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Review Immunology

Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy

Cuipeng Zhu et al.

Summary: Berberine (BBR), an alkaloid extracted from Coptidis Rhizoma, has various pharmacological properties including anti-inflammatory, antibacterial, antioxidant, anti-obesity, and even antitumor effects. Recent studies have also focused on the modulatory effects of BBR on nutritional immune responses. This mini-review summarizes the latest research on the inflammation, gut microbes, macrophage polarization, and immune responses related to BBR's tools in the pathogenesis and therapy of ulcerative colitis and cancer in the past 5 years. The therapeutic efficacy and anti-inflammatory actions of BBR are also discussed for future clinical applications.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Infectious Diseases

How has mass drug administration with dihydroartemisinin-piperaquine impacted molecular markers of drug resistance? A systematic review

Sophie Moss et al.

Summary: Surveillance of molecular markers of resistance to anti-malarial drugs is recommended by WHO, but its implementation following mass drug administration (MDA) is not common. Limited studies suggest that the impact of MDA with DHA-PPQ on molecular markers of drug resistance may vary, but standardized monitoring methods are lacking.

MALARIA JOURNAL (2022)

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Article Oncology

Green Tea Polyphenols Cause Apoptosis and Autophagy in HPV-16 Subgene-Immortalized Human Cervical Epithelial Cells via the Activation of the Nrf2 Pathway

Yi Tang et al.

Summary: Green tea polyphenol (GTP) induces autophagy and apoptosis in HPV-16-positive cells through regulating the Nrf2 pathway, alleviating HPV infection and associated precancerous lesions.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2022)

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Review Nutrition & Dietetics

Promising bioactive properties of quercetin for potential food applications and health benefits: A review

Irtiqa Shabir et al.

Summary: Quercetin and its derivatives are naturally occurring phytochemicals with promising biological properties, including anticancer, antidiabetic, and antibacterial effects. They can be found in fruits, vegetables, and coffee, and consuming them as part of a meal or as a supplement may benefit one's health.

FRONTIERS IN NUTRITION (2022)

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Review Food Science & Technology

Therapeutic application of carvacrol: A comprehensive review

Muhammad Imran et al.

Summary: Carvacrol, a natural component found in aromatic plants, possesses various biological activities such as antioxidant, anticancer, and antimicrobial properties. It has the potential to promote health through multiple pathways.

FOOD SCIENCE & NUTRITION (2022)

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Review Pharmacology & Pharmacy

Ginsenosides: Allies of gastrointestinal tumor immunotherapy

Yutao Feng et al.

Summary: This article summarizes the research on the use of ginsenosides in immunotherapy of gastrointestinal tumors and discusses their potential future applications.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Oncology

Recurrent or primary metastatic cervical cancer: current and future treatments

C. Gennigens et al.

Summary: Despite existing screening programs and human papillomavirus vaccines, there is still a significant number of women with primary metastatic cervical cancer and recurrent cases with poor prognosis. Previous standard treatments include cisplatin-based therapies, but the addition of bevacizumab to chemotherapy has shown promise. Recent interest has focused on using immunotherapeutic drugs, such as immune checkpoint inhibitors and antibody-drug conjugates, to achieve durable responses and improve overall survival. However, the identification of potent biomarkers and targeted therapies is crucial for personalized treatment strategies.

ESMO OPEN (2022)

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Article Chemistry, Medicinal

In Vitro, Molecular Docking and In Silico ADME/Tox Studies of Emodin and Chrysophanol against Human Colorectal and Cervical Carcinoma

Wasim Ahmad et al.

Summary: In this study, anthraquinone derivatives chrysophanol (Chr) and emodin (EM) showed strong anti-cancer effects and had better binding energies than the FDA-approved anticancer drug fluorouracil, according to molecular docking studies. In vitro experiments confirmed the promising anticancer activity of Chr and EM in HCT-116 and HeLa cells, laying the foundation for their potential use in the treatment of human colorectal and cervical carcinomas.

PHARMACEUTICALS (2022)

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Review Oncology

HPV vaccination and HPV-related malignancies: impact, strategies and optimizations toward global immunization coverage

Gaia Giannone et al.

Summary: HPV vaccination plays a crucial role in eliminating cervical cancer and other HPV-related malignancies. The global strategy aims to vaccinate 90% of young girls worldwide by 2030, requiring optimization of vaccination programs, increased financial support, and awareness.

CANCER TREATMENT REVIEWS (2022)

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Article Biochemistry & Molecular Biology

Ursolic Acid Derivative UA232 Promotes Tumor Cell Apoptosis by Inducing Endoplasmic Reticulum Stress and Lysosomal Dysfunction

Wenfeng Gou et al.

Summary: UA232, a derivative of ursolic acid, demonstrates anti-tumor effects against breast and cervical cancer cells by inducing apoptosis and promoting autophagy. The compound exerts its pharmacological effects through triggering endoplasmic reticulum stress and lysosomal dysfunction, making it a promising candidate for cancer treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Biochemistry & Molecular Biology

20(S)-Ginsenoside Rh2-induced apoptosis and protective autophagy in cervical cancer cells by inhibiting AMPK/mTOR pathway

Shuai Bian et al.

Summary: 20(S)-GRh2 inhibits proliferation and induces apoptosis in HeLa cells by activating intrinsic apoptotic pathway and causing mitochondrial dysfunction, while enhancing autophagy by promoting AMPK phosphorylation and suppressing mTOR activity. The use of autophagy inhibitors enhances 20(S)-GRh2-induced apoptosis, while autophagy inducers promote cell survival. Additionally, the protective autophagy induced by 20(S)-GRh2 inhibits the AMPK/mTOR pathway, promoting apoptosis in cervical cancer cells.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2022)

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Article Chemistry, Applied

Three new steroidal components from the roots of reineckia carnea

Linfeng Zheng et al.

Summary: A new coprostanol glycoside and a new C-22 steroidal lactone saponin, along with two known pregnane glycosides, were isolated from the roots of Reineckia carnea. Compound 1 showed weak cytotoxic effect against tumor cells.

NATURAL PRODUCT RESEARCH (2021)

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Article Medicine, General & Internal

Dihydroartemisinin and its anticancer activity against endometrial carcinoma and cervical cancer: involvement of apoptosis, autophagy and transferrin receptor

Tian Tang et al.

Summary: The study demonstrates that DHA alone or in combination with cisplatin can induce cell death in endometrial carcinoma and cervical cancer cells, and inhibiting autophagy enhances the cytotoxicity of DHA towards tumor cells. DHA is also involved in anticancer mechanisms by regulating apoptosis, the autophagy pathway, and levels of transferrin receptor.

SINGAPORE MEDICAL JOURNAL (2021)

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Article Cell Biology

Proteasomal dysfunction and ER stress triggers 2′-hydroxy-retrochalcone-induced paraptosis in cancer cells

Divya Nedungadi et al.

Summary: The study found that 2'-hydroxy-retrochalcone (HRC) was the most effective in inducing paraptosis in malignant breast and cervical cancer cells, with a non-apoptotic nature and ER stress involvement. HRC was also shown to inhibit proteasomal activity, collapse mitochondrial membrane potential, and deplete ATP to trigger cell death. Thiol antioxidants and cycloheximide were able to inhibit this programmed cell death, suggesting HRC as a potential lead molecule for anticancer therapy.

CELL BIOLOGY INTERNATIONAL (2021)

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Review Virology

Regulation of autophagy by high- and low-risk human papillomaviruses

Ana Karina Aranda-Rivera et al.

Summary: Research has shown that high-risk HPV infection is associated with the development of various cancers, while low-risk HPV infection mainly causes genital warts. High-risk HPV promotes tumor development by altering the expression of cellular proteins, while the oncogenic potential of low-risk HPV is relatively lower.

REVIEWS IN MEDICAL VIROLOGY (2021)

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Article Nutrition & Dietetics

6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway

Xiao-Dong Pei et al.

Summary: 6-Shogaol, an active compound from ginger, inhibits cell proliferation and migration in cervical cancer cells, induces cell cycle arrest at G2/M phase, and triggers apoptosis through the mitochondrial pathway by downregulating expression levels of related proteins.

EUROPEAN JOURNAL OF NUTRITION (2021)

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Article Biochemistry & Molecular Biology

The potential antitumor effect of chrysophanol in relation to cervical cancer cells

Wojciech Trybus et al.

Summary: The study demonstrates that chrysophanol exerts anti-tumor activity on cervical cancer cells by inhibiting cell viability, inducing apoptosis, causing DNA damage, and affecting cellular degradation processes and organelle structures, particularly mitochondria, possibly through increasing free radical levels. The observed effects varied depending on the concentration of anthraquinone tested.

JOURNAL OF CELLULAR BIOCHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

ATG 4B Serves a Crucial Role in RCE-4-Induced Inhibition of the Bcl-2-Beclin 1 Complex in Cervical Cancer Ca Ski Cells

Fang-Fang You et al.

Summary: RCE-4, a steroidal saponin isolated from Reineckia carnea, exhibits promising anti-cervical cancer properties by inducing programmed cell death in Ca Ski cells. The study targeting the Bcl-2-Beclin 1 complex revealed that RCE-4 inhibited its formation in Ca Ski cells, enhancing its sensitivity through various pathways. Additionally, ATG 4B proteins played a key role in this process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Synergistic Effect of Apigenin and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa Cells

Sera Kayacan et al.

Summary: The combination of apigenin and curcumin increased the expression levels of genes related to cell death in HeLa cells and showed a synergistic anti-tumor effect via cross-talk between processes leading to apoptosis and autophagic cell death.

ANTICANCER RESEARCH (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Effect of berberine nanoemulsion Photodynamic therapy on cervical carcinoma cell line

Barbara Freitas Floriano et al.

Summary: Berberine, a natural compound derived from plants, has shown potential as a photosensitizing agent in photodynamic therapy for cervical carcinoma. When combined with nanoemulsions, it demonstrated significant phototoxicity in cancer cell lines, indicating its promise for future clinical applications.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

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Article Oncology

Biology of HPV Mediated Carcinogenesis and Tumor Progression

Pippa F. Cosper et al.

Summary: The article provides an overview of HPV virus classification, genetic structure, life cycle, and its role in cancer. The virus promotes tumorigenesis through integration into host genome, regulating cell cycle and apoptosis, and suppressing immune response.

SEMINARS IN RADIATION ONCOLOGY (2021)

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Review Virology

Persistent Human Papillomavirus Infection

Ashley N. Della Fera et al.

Summary: Persistent infection with oncogenic human papillomavirus (HPV) types contributes to approximately 5% of human cancers. The HPV infectious cycle and viral proteins manipulate cellular proliferation and differentiation, increasing the risk of carcinogenesis in infected cells.

VIRUSES-BASEL (2021)

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Article Pharmacology & Pharmacy

Roles of autophagy in relation to mitochondrial stress responses of HeLa cells to lamellarin cytotoxicity

Pattarawut Sopha et al.

Summary: The study reveals that lamellarins and their analogs induce apoptosis, mitochondrial stress responses, and autophagy in HeLa cancer cells, showcasing their potential as prospective anti-cancer agents. Additionally, the modulation of cellular autophagy flux by lamellarins affects the number of apoptotic cells induced by these compounds, highlighting the complex interplay between apoptosis and autophagy in cancer cell death.

TOXICOLOGY (2021)

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Review Pharmacology & Pharmacy

Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer

Yuan Cai et al.

Summary: Alantolactone, a natural compound from Chinese traditional medicine, shows therapeutic potential in treating various cancers by affecting cancer-associated signaling pathways and regulatory factors. Studies suggest promising strategies to enhance its oral bioavailability, such as combining with other herbs or using nanostructured carriers.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Nujiangexanthone A Inhibits Cervical Cancer Cell Proliferation by Promoting Mitophagy

Jiling Feng et al.

Summary: NJXA can induce cell death in HeLa cells by promoting mitophagy, degrading mitochondrial membrane proteins, downregulating Parkin, stabilizing PINK1, and inducing lysosome degradation. This shows a cytotoxic effect on cervical cancer cells.

MOLECULES (2021)

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Article Multidisciplinary Sciences

Alantolactone inhibits cervical cancer progression by downregulating BMI1

Xiaodong Sun et al.

Summary: This study highlights the significant role of BMI1 in cervical cancer, with high expression associated with poor differentiation, high clinical grade, and poor prognosis. Furthermore, alantolactone shows promising effects in reducing proliferation, migration, and invasion of cervical cancer cells, as well as promoting autophagy and mitochondrial damage.

SCIENTIFIC REPORTS (2021)

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Review Chemistry, Medicinal

Natural and Synthetic Naphthoquinones as Potential Anti-Infective Agents

Eyra Ortiz-Perez et al.

Summary: Naphthoquinones are aromatic compounds with antibacterial, antifungal, and antiprotozoal properties, which can be obtained from both natural and synthetic sources. Research on naphthoquinones and their derivatives contributes to the development of new chemotherapeutic agents against parasitic diseases.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Autophagy in major human diseases

Daniel J. Klionsky et al.

Summary: Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.

EMBO JOURNAL (2021)

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Article Oncology

Effects of photodynamic therapy mediated by emodin in cervical carcinoma cells

Ana Emilia Brumatti Galiardi-Campoy et al.

Summary: The combination of emodin with photodynamic therapy showed significant cytotoxic effects on cervical carcinoma cell lines, leading to cell death through increased ROS production resulting in apoptosis and autophagy. Fluorescence microscopy images demonstrated efficient cellular uptake of emodin and the overexpression of multiple target genes in SiHa cells following treatment.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

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Review Virology

Human Papillomaviruses Target the DNA Damage Repair and Innate Immune Response Pathways to Allow for Persistent Infection

Elona Gusho et al.

Summary: Persistent infection with high-risk HPVs is a major risk factor for anogenital and oropharyngeal cancers. HPV replication depends on the activation of DNA damage repair pathways and evasion of immune surveillance. Targeting these processes with antiviral therapies may offer treatment opportunities for HPV-induced cancers.

VIRUSES-BASEL (2021)

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Article Cell Biology

Physcion Induces Potential Anticancer Effects in Cervical Cancer Cells

Wojciech Trybus et al.

Summary: Physcion exerts antitumor effects by inducing oxidative stress, autophagy, and apoptosis in HeLa cells, resulting in decreased cell viability, G0/G1 phase cell cycle arrest, and activation of the lysosomal system.

CELLS (2021)

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Article Biochemistry & Molecular Biology

Ginsenoside CK induces apoptosis of human cervical cancer HeLa cells by regulating autophagy and endoplasmic reticulum stress

Qi Yin et al.

Summary: This study revealed that Ginsenoside CK (GCK) inhibits proliferation, induces cell cycle arrest, alters ROS levels, promotes apoptosis, and affects multiple pathways in cervical cancer HeLa cells. It suggests that GCK could be a potential natural product for treating cervical cancer.

FOOD & FUNCTION (2021)

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Article Virology

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Neferine, an alkaloid from lotus seed embryo targets HeLa and SiHa cervical cancer cells via pro-oxidant anticancer mechanism

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Anti-Tumor Xanthones from Garcinia nujiangensis Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells

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Rosmarinic Acid Methyl Ester Regulates Ovarian Cancer Cell Migration and Reverses Cisplatin Resistance by Inhibiting the Expression of Forkhead Box M1

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Emodin Induces Death in Human Cervical Cancer Cells Through Mitotic Catastrophe

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Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling

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Cardiac Glycoside Compound Isolated from Helleborus thibetanus Franch Displays Potent Toxicity against HeLa Cervical Carcinoma Cells through ROS-Independent Autophagy

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Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy

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Licochalcone A isolated from licorice suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice

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