Modified Xiaoyao San reverses lipopolysaccharide-induced depression-like behavior through suppressing microglia M1 polarization via enhancing autophagy involved in PI3K/Akt/mTOR pathway in mice

Article Plant Sciences

Xiaoyao San attenuates hepatic steatosis through estrogen receptor α pathway in ovariectomized ApoE-/- mice

Tianhui Hu et al.

Summary: Research findings indicate that Xiaoyao San inhibits hepatic steatosis in postmenopausal animal models by reducing the expression of genes related to triglyceride synthesis through the estrogen receptor alpha pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation

Guiqin Bai et al.

Summary: The study showed that Jiao-Tai-Wan may ameliorate neuronal damage in depression mice by inhibiting CSF1R-mediated microglia activation and pro-inflammatory response.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Neurosciences

Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance

Mai Sakai et al.

Summary: This study explores the changes in autophagy signaling in the prefrontal cortex (PFC) under repeated social defeat (RSD) and their potential involvement in behavioral changes induced by stress. The results suggest that enhanced autophagy may alleviate stress-induced depression, and microglial autophagy plays a role in stress-induced behavioral changes.

NEURAL PLASTICITY (2022)

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Article

Macrophage and microglia polarization: focus on autophagy-dependent reprogramming

Svetlana G. Zubova et al.

Frontiers in Bioscience - Scholar (2022)

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Review Plant Sciences

Canonical Chinese medicine formula Danzhi-Xiaoyao-San for treating depression: A systematic review and meta-analysis

Xiao-Le Wang et al.

Summary: This systematic review and meta-analysis found that Danzhi-Xiaoyao-San (DXS) had a similar effect to antidepressants in terms of clinical comprehensive effect and decrease in Self-Rating Depression Scale scores, but had a lower effect in Hamilton Depression Scale scores. Furthermore, the combination of DXS and antidepressants showed significant improvement in clinical comprehensive effect and decrease in Hamilton Depression Scale scores compared to pure antidepressants.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Review Plant Sciences

A review of the ethnopharmacology, phytochemistry, pharmacology and toxicology of Fructus Gardeniae (Zhi-zi)

Jingzhuo Tian et al.

Summary: Fructus Gardeniae (FG), dried fruit of Gardenia jasminoides Ellis, has a long history of use in traditional Chinese medicine as both medicine and food. FG's main active ingredients have various pharmacological properties, but may also cause multiple organ injury, especially hepatotoxicity and nephrotoxicity, requiring caution in clinical use.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Baihe Dihuang (Lilium Henryi Baker and Rehmannia Glutinosa) decoction attenuates somatostatin interneurons deficits in prefrontal cortex of depression via miRNA-144-3p mediated GABA synthesis and release

Xiaoyan Xue et al.

Summary: Baihe Dihuang Decoction (LBRD) is a traditional Chinese medicine prescription with nourishing yin and clearing heat properties. This study found that LBRD can ameliorate GABA deficits in depression by regulating miRNA-144-3p mediated GABA synthesis and release, improving the SST-positive neuron deficits.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Natural products for the treatment of stress-induced depression: Pharmacology, mechanism and traditional use

Wei Dai et al.

Summary: This review provides insights into the pathological mechanism and animal models of stress-induced depression, as well as natural products with antidepressant activity, shedding light on the potential therapeutic effects and clinical potential of these compounds. Natural products also hold promise as a vital source for future antidepressant drug discovery.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Clinical Neurology

Ketamine Regulates the Autophagy Flux and Polarization of Microglia through the HMGB1-RAGE Axis and Exerts Antidepressant Effects in Mice

Meng Wu et al.

Summary: In this study, the role of the HMGB1-RAGE pathway in LPS-induced depression-like behavior and microglial autophagy flux, neuroinflammation, and polarization was explored. Ketamine was found to improve depression-like behavior, inhibit the upregulation of HMGB1 and RAGE, and regulate microglial autophagy flux through the HMGB1-RAGE pathway and microglial polarization. These findings suggest that ketamine may be a new therapeutic target for preventing and treating depression.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2022)

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Review Neurosciences

Prefrontal cortex and depression

Diego A. Pizzagalli et al.

Summary: Dissecting depressive phenotypes into biologically more tractable dimensions provides an opportunity to integrate clinical findings with mechanistic evidence from preclinical models, promising to enhance our understanding of major depressive disorder.

NEUROPSYCHOPHARMACOLOGY (2022)

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Article Chemistry, Applied

Simultaneous determination of multiple components in formula and preparations of Xiaoyaosan

Haibo Su et al.

Summary: Xiaoyaosan is a well-known traditional Chinese medicine formula for liver, spleen, and blood deficiency syndrome. A new ultra-performance liquid chromatography method has been established to accurately and rapidly quantify multiple components in Xiaoyaosan preparations, providing a reliable reference for quality evaluation during manufacture, administration, and clinical application.

NATURAL PRODUCT RESEARCH (2021)

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Review Neurosciences

Neuroinflammation and depression: A review

Romain Troubat et al.

Summary: Neuroinflammation interacts with key neurobiological factors of depression, potentially presenting a crucial therapeutic target for future treatments. This interaction may impact serotonin levels, HPA axis regulation, and hippocampal neurogenesis, leading to the pathophysiological cascade of increased glutamate levels and altered neurotransmission. It can be triggered by chronic inflammatory conditions or primary brain neuroinflammation, highlighting the importance of addressing neuroinflammation in the treatment of major depressive disorder.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

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Review Biology

Microglia in depression: current perspectives

Xiaoning Jia et al.

Summary: This review focuses on the role of microglia in the etiology of depression, discussing the dynamic states of microglia, the correlative and causal evidence of microglial abnormalities in depression, possible mechanisms of how microglia sense depression-related stress and modulate depression state, and how antidepressive therapies affect microglia. Understanding the role of microglia in depression may lead to new treatment strategies for fighting against this mental illness.

SCIENCE CHINA-LIFE SCIENCES (2021)

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Article Plant Sciences

Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation

Yunfeng Zhou et al.

Summary: Radix Polygalae (RP) demonstrated remarkable antidepressant activity in behavioral despair mice and chronic restraint stress (CRS)-induced rats, possibly by promoting autophagy and inhibiting neuroinflammation.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia

Sung Hee Park et al.

Summary: Fluoxetine has regulatory effects on microglial function, reducing the production of proinflammatory cytokines and oxidative stress, while enhancing phagocytosis and autophagy in microglia.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Plant Sciences

Paeoniflorin exerts antidepressant-like effects through enhancing neuronal FGF-2 by microglial inactivation

Jie Cheng et al.

Summary: The study demonstrated that paeoniflorin exhibits neuroprotective and antidepressant effects in mice by activating neuronal FGF-2/FGFR1 signaling pathway and inhibiting microglial activation in the hippocampus, suggesting its potential therapeutic application for depression.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

The interaction between autophagy and neuroinflammation in major depressive disorder: From pathophysiology to therapeutic implications

Mimi Tang et al.

Summary: Neuroinflammation has been identified as an important mechanism of major depressive disorder, with the NLRP3 inflammasome playing a critical role in its pathogenesis. The autophagy signaling pathway is essential for regulating NLRP3 inflammasome activity, preventing excessive activation and release of inflammatory cytokines.

PHARMACOLOGICAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Autophagy Modulators and Neuroinflammation

Kyoung Sang Cho et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Article Behavioral Sciences

SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice

Chun-Mei Duan et al.

BEHAVIOURAL BRAIN RESEARCH (2020)

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Article Immunology

Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation

Xiaoxia Ye et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Endocrinology & Metabolism

Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation

Tahir Ali et al.

JOURNAL OF PINEAL RESEARCH (2020)

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Article Pharmacology & Pharmacy

An Integrated Pharmacology-Based Analysis for Antidepressant Mechanism of Chinese Herbal Formula Xiao-Yao-San

Naijun Yuan et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Pharmacology & Pharmacy

Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer's Disease

Shi-Yu Chen et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Microglia: A Central Player in Depression

Si-long Deng et al.

CURRENT MEDICAL SCIENCE (2020)

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Review Neurosciences

The Bidirectional Relationship of Depression and Inflammation: Double Trouble

Eleonore Beurel et al.

NEURON (2020)

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Article Psychiatry

Effects of Xiaoyaosan on Depressive-Like Behaviors in Rats With Chronic Unpredictable Mild Stress Through HPA Axis Induced Astrocytic Activities

Ming Song et al.

FRONTIERS IN PSYCHIATRY (2020)

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Review Chemistry, Medicinal

Polygalae Radix: A review of its traditional uses, phytochemistry, pharmacology, toxicology, and pharmacokinetics

Xin Zhao et al.

FITOTERAPIA (2020)

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Article Immunology

Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia

Tingting He et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Clinical Neurology

Modified Xiaoyaosan reverses aberrant brain regional homogeneity to exert antidepressive effects in mice

Yanmeng Bi et al.

NEUROPATHOLOGY (2019)

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Review Pharmacology & Pharmacy

Molecular aspects of depression: A review from neurobiology to treatment

Gustavo Roberto Villas Boas et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Review Immunology

Role of inflammation in depression relapse

Chun-Hong Liu et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Article Immunology

Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

Li-Ting Guo et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Article Nutrition & Dietetics

The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice

Huiling Chen et al.

NUTRIENTS (2019)

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Review Psychiatry

Is There a Role of Autophagy in Depression and Antidepressant Action?

Nils C. Gassen et al.

FRONTIERS IN PSYCHIATRY (2019)

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Article Immunology

Activation of GPR55 induces neuroprotection of hippocampal neurogenesis and immune responses of neural stem cells following chronic, systemic inflammation

Jeremy D. Hill et al.

BRAIN BEHAVIOR AND IMMUNITY (2019)

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Article Plant Sciences

Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat

Jiajia Wang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2018)

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Article Pharmacology & Pharmacy

Modified Xiaoyaosan (MXYS) Exerts Anti-depressive Effects by Rectifying the Brain Blood Oxygen Level-Dependent fMRI Signals and Improving Hippocampal Neurogenesis in Mice

Lei Gao et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Neurosciences

Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder

Lijuan Zhang et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Geriatrics & Gerontology

A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration

Meng-meng Jin et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

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Article Neurosciences

Spared Nerve Injury Increases the Expression of Microglia M1 Markers in the Prefrontal Cortex of Rats and Provokes Depression-Like Behaviors

Ning Xu et al.

FRONTIERS IN NEUROSCIENCE (2017)

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Article Neurosciences

Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway

Francis L. Pazini et al.

MOLECULAR NEUROBIOLOGY (2016)

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Article Behavioral Sciences

Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway

Weiwei Tao et al.

BEHAVIOURAL BRAIN RESEARCH (2016)

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Article Immunology

Depression-like behaviors and heme oxygenase-1 are regulated by Lycopene in lipopolysaccharide-induced neuroinflammation

Fang Zhang et al.

JOURNAL OF NEUROIMMUNOLOGY (2016)

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Review Neurosciences

THE ROLE OF AUTOPHAGY IN MODULATION OF NEUROINFLAMMATION IN MICROGLIA

P. Su et al.

NEUROSCIENCE (2016)

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Review Integrative & Complementary Medicine

Prescription of Chinese Herbal Medicine in Pattern-Based Traditional Chinese Medicine Treatment for Depression: A Systematic Review

Wing-Fai Yeung et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015)

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Article Plant Sciences

Danzhi Xiaoyao San ameliorates depressive-like behavior by shifting toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase

Xiaoxia Zhu et al.

JOURNAL OF ETHNOPHARMACOLOGY (2015)

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Article Plant Sciences

Effects of the total flavonoid extract of Xiaobuxin-Tang on depression-like behavior induced by lipopolysaccharide and proinflammatory cytokine levels in mice

Lei An et al.

JOURNAL OF ETHNOPHARMACOLOGY (2015)

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Review Integrative & Complementary Medicine

Effect of Xiaoyaosan on major depressive disorder

Lin-Lin Jing et al.

CHINESE MEDICINE (2015)

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Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

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Review Chemistry, Analytical

Recent analytical approaches in quality control of traditional Chinese medicines-A review

Yong Jiang et al.

ANALYTICA CHIMICA ACTA (2010)

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Article Plant Sciences

Metabolomics study on the anti-depression effect of xiaoyaosan on rat model of chronic unpredictable mild stress

Yuntao Dai et al.

JOURNAL OF ETHNOPHARMACOLOGY (2010)

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Modified Xiaoyao San reverses lipopolysaccharide-induced depression-like behavior through suppressing microglia M1 polarization via enhancing autophagy involved in PI3K/Akt/mTOR pathway in mice

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