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Potential applications of mesoporous silica nanoparticles for the treatment of neurological disorders

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2023)

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Article Pharmacology & Pharmacy

Mesoporous silica nanoparticles as carrier to overcome bacterial drug resistant barriers

Jie Zhuang et al.

Summary: Due to abuse of antibiotics, antibiotic resistance has become a global health threat. Many existing antibiotics have lost their effectiveness against drug-resistant bacteria, and the discovery of new antibiotics is becoming increasingly difficult. It is necessary to develop new strategies to combat antibiotic resistance. Nano-drug delivery systems, particularly mesoporous silica nano-particles (MSNs), have been extensively investigated as carriers of antibiotics. MSNs improve the delivery of antibiotics by reducing size, modifying surface, and regulating shapes. Furthermore, MSNs hybridized with metal ions or nanoparticles enhance the antibacterial effect by controlling the release of metal ions or increasing active oxygen species. Metal-capped MSNs can also load antibiotics to exert a synergistic antibacterial effect. This paper reviews the current application of various nanomaterials as antibacterial agents, with a focus on MSNs and approaches for improving their antibacterial effect.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

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Article Chemistry, Applied

Impact of porosity and surface functionalization of hard templates on the preparation of mesoporous silica microspheres

Fabio Fait et al.

Summary: Mesoporous silica microspheres (MPSMs) are prepared using p(GMA-co-EDMA) as hard templates with different porosity and surface functionalization. The incorporation of GMA into the template is determined by a PLS-R model based on FTIR spectra. Silica nanoparticles (SNPs) are deposited into the template and subsequently removed by calcination to form MPSMs with different pore parameters. The pore structure and separation properties of the silica particles are determined by the pore characteristics and functionalization of the template.

MICROPOROUS AND MESOPOROUS MATERIALS (2023)

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Article Chemistry, Multidisciplinary

Fast Microwave-Assisted Synthesis, Calcination and Functionalization of a Silica Mesoporous Nanomaterial: UVM-7

Borja Diaz de Grenu et al.

Summary: In this study, the use of a solid state microwave source for the synthesis, calcination and functionalization of a UVM-7 based hybrid mesoporous silica material was demonstrated. The synthesis of the material could be achieved in just 2 minutes at low power, while the calcination and functionalization processes only took 13 and 4 minutes respectively with microwave assisted procedures. The total synthesis time was significantly reduced compared to traditional methods, leading to significant time and energy savings.

CHEMSUSCHEM (2023)

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Article Pharmacology & Pharmacy

Nose-to-brain drug delivery for the treatment of Alzheimer's disease: current advancements and challenges

A. Prabakaran et al.

Summary: The nose-to-brain delivery approach shows great potential for the treatment of Alzheimer's disease by improving drug bioavailability in the brain. This review article explores the current facts and statistics of AD, barriers to brain delivery, and recent advancements in nose-to-brain delivery using various carrier systems. It emphasizes the potential of this approach to overcome limitations of current therapies and enhance therapeutic potency.

EXPERT OPINION ON DRUG DELIVERY (2022)

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Review Biology

Gap Junctions and Hemichannels Composed of Connexins and Pannexins Mediate the Secondary Brain Injury Following Intracerebral Hemorrhage

Yan Zhang et al.

Summary: Intracerebral hemorrhage (ICH) is a devastating disease that affects approximately 2 million patients worldwide annually. This review focuses on understanding the pathological roles of gap junctions and hemichannels in secondary brain injury following ICH, with the aim of identifying effective therapeutic strategies for ICH.

BIOLOGY-BASEL (2022)

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Review Biochemistry & Molecular Biology

Proteomics in Multiple Sclerosis: The Perspective of the Clinician

Daniel Sandi et al.

Summary: Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system and approximately 2.8 million people worldwide. Despite advancements in personalized medicine, there are still many unknown aspects of the disease that require further research. Proteomics, a rapidly evolving discipline, has shown promise in identifying molecular biomarkers for the diagnosis, differential diagnosis, and therapy of MS. This review highlights the utility of proteomics in MS research and its potential for important findings.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Chemistry, Multidisciplinary

Glioma diagnosis and therapy: Current challenges and nanomaterial-based solutions

Tianzhong Li et al.

Summary: Glioma, one of the most dreadful central nervous system tumors, has a high incidence rate and remains a significant challenge for treatment. However, the development of nanomedicine provides new opportunities for long-term therapy. Various obstacles, such as the blood-brain barrier permeation, hypoxia, and complex tumor microenvironment, hinder the development of novel therapeutics. Efforts have been made to explore nanoformulations to improve permeation and address these challenges. The article provides an overview of glioma classification, pathogenic factors, current therapeutic approaches, and innovative strategies, concluding with suggestions for future improvement in diagnosis and therapy.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Pharmacology & Pharmacy

Exploiting mesoporous silica, silver and gold nanoparticles for neurodegenerative diseases treatment

Tais C. Ribeiro et al.

Summary: Neurodegenerative diseases are a public health problem causing cognitive and behavioral impairments. Current drugs can only control symptoms but cannot prevent neural loss. Nanotechnology-based drug delivery systems have been developed to optimize treatment, especially for Alzheimer's and Parkinson diseases.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Review Chemistry, Physical

Recent trends in mesoporous silica nanoparticles of rode-like morphology for cancer theranostics: A review

Saman Sargazi et al.

Summary: The shape of nanoparticles is crucial for drug delivery efficiency. Rod-shaped mesoporous silica nanoparticles (RMSNs) have shown advantages over spherical MSNs in targeted drug delivery. RMSNs have desirable properties such as biocompatibility, low toxicity, large surface area, and stability, making them a perfect nanostructure. They have been utilized in various applications including bioimaging, cancer treatment, and drug/gene delivery.

JOURNAL OF MOLECULAR STRUCTURE (2022)

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Review Pharmacology & Pharmacy

Key Parameters for the Rational Design, Synthesis, and Functionalization of Biocompatible Mesoporous Silica Nanoparticles

Marta Florensa et al.

Summary: Research on silica nanoparticles, particularly mesoporous silica nanoparticles (MSNs), has rapidly increased in recent years. MSNs have been widely studied as nanocarriers for the treatment of various diseases due to their physicochemical properties and biocompatibility. This review provides an overview of recent advances in the field of silica nanoparticles, focusing on the synthesis of functional MSNs and their biomedical applications. The review also highlights the importance of synthesis conditions in determining the properties and behavior of MSNs.

PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Evaluation of the therapeutic effect of mesoporous silica nanoparticles loaded with Gallic acid on reserpine-induced depression in Wistar rats

Heba M. Fahmy et al.

Summary: This study evaluated the antidepressant effect of free gallic acid (GA) and GA-loaded mesoporous silica nanoparticles (MSNs) in a rat model of depression caused by reserpine. It was found that GA-loaded MSNs can selectively target specific brain areas and regulate oxidative stress biomarkers and monoamine neurotransmitter levels more effectively.

BMC PHARMACOLOGY & TOXICOLOGY (2022)

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Article Materials Science, Multidisciplinary

Novel lactoferrin-functionalized manganese-doped silica hollow mesoporous nanoparticles loaded with resveratrol for the treatment of ischemic stroke

Zhiru Zou et al.

Summary: This study aimed to design lactoferrin functionalized hollow mesoporous manganese doped silica nanoparticles (LHMMSN) for the delivery of insoluble drug resveratrol (RES) to reduce inflammation and protect nerve cells in stroke. In vitro and in vivo experiments showed that LHMMSN-RES increased antioxidant enzyme activity, reduced reactive oxygen species, increased expression of anti-inflammatory and anti-apoptotic factors, and decreased expression of pro-inflammatory and pro-apoptotic factors in brain tissue, promoting the recovery of motor function in a stroke rat model.

MATERIALS TODAY ADVANCES (2022)

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Article Pharmacology & Pharmacy

Gefitinib-loaded polydopamine-coated hollow mesoporous silica nanoparticle for gastric cancer application

Ali Jadidi et al.

Summary: This study developed a pH-sensitive drug delivery system for the treatment of gastric cancer. The system showed selective cytotoxicity towards gastric cancer cells, sustained release, and high mucoadhesive properties.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Review Biotechnology & Applied Microbiology

Recent advances in mesoporous silica nanoparticle-based targeted drug-delivery systems for cancer therapy

Ying Li et al.

Summary: Mesoporous silica nanoparticles (MSNs) have been extensively studied and applied in targeted drug-delivery systems for tumor therapy. They possess outstanding features, such as high surface area, large pore volume, tunable pore size, easy surface modification, and stable framework. This review covers the advances, challenges, and prospects of MSN-based targeted drug-delivery systems for anticancer treatment, providing new insights for researchers in this field.

NANOMEDICINE (2022)

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Review Pharmacology & Pharmacy

Mesoporous silica nanoparticles: synthesis methods and their therapeutic use-recent advances

Mohsen Ghaferi et al.

Summary: Mesoporous silica nanoparticles (MSNPs) are innovative nanomaterials used for drug delivery systems with the potential to deliver therapeutic agents, mitigate disease progression, and improve cancer treatment. The properties, characteristics, and therapeutic applications of MSNPs have been studied, along with their potential for diagnosis and disease management. Emerging trends and future advancements of MSNPs as carriers have also been discussed.

JOURNAL OF DRUG TARGETING (2021)

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Review Engineering, Biomedical

Advances in regulating physicochemical properties of mesoporous silica nanocarriers to overcome biological barriers

Yumei Wang et al.

Summary: Mesoporous silica nanoparticles (MSNs) have been proven to be an excellent platform for drug delivery, but biological barriers present challenges. The physicochemical parameters of MSNs affect their ability to cross biological barriers, and surface modification is an important strategy for achieving rapid transport.

ACTA BIOMATERIALIA (2021)

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Article Biochemistry & Molecular Biology

Angiopep-2 modi fi ed lipid-coated mesoporous silica nanoparticles for glioma targeting therapy overcoming BBB

Jingjing Zhu et al.

Summary: This study developed a novel nanomedicine for treating glioma, which achieved better drug targeting effect and showed significant improvement in treatment efficacy and survival time in animal experiments.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

A Tauopathy-Homing and Autophagy-Activating Nanoassembly for Specific Clearance of Pathogenic Tau in Alzheimer's Disease

Heng Sun et al.

Summary: The study introduces a promising nanotechnology-based strategy for tauopathy-homing and autophagy-mediated specific removal of pathogenic tau in Alzheimer's disease (AD), showing selective accumulation in cells undergoing tauopathy and promoting clearance of pathogenic tau accumulation, consequently improving neuron viability and cognitive functions in AD rats.

ACS NANO (2021)

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Article Chemistry, Applied

Mesoporous silica nanoparticle: Heralding a brighter future in cancer nanomedicine

Milad Abbasi et al.

Summary: In recent years, clinical oncology has been focused on designing targeted delivery technologies to optimize the medical response to tumor disease by delivering antitumor medicines and diagnostic agents to tumor sites. Localized delivery of medicines and diagnostic agents is essential to enhance treatment effectiveness and minimize adverse effects in cancer therapy.

MICROPOROUS AND MESOPOROUS MATERIALS (2021)

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Review Chemistry, Medicinal

A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease

Yash Pal Singh et al.

Summary: Alzheimer's disease is an age-related neurodegenerative disorder characterized by central cholinergic neuronal loss leading to cognitive dysfunction and impaired motor activity. Current therapies only offer symptomatic relief without addressing the underlying factors, and there is no drug to slow down disease progression. Researchers are investigating new hybrid compounds, such as ferulic acid-based derivatives, as potential treatments for Alzheimer's disease.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Pharmacology & Pharmacy

Role of natural products for the treatment of Alzheimer's disease

Tayebeh Noori et al.

Summary: Negative psychological and physiological consequences of neurodegenerative disorders, especially Alzheimer's disease, affect millions of people globally. Current treatments focus on symptom management, with natural products showing promise in preventing and alleviating symptoms of AD.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives

Kehinde D. Fasae et al.

Summary: Alzheimer's disease is the leading cause of cognitive impairment and dementia globally, with various hypotheses on its pathobiology but no confirmed diagnostics or approved cure. Studies suggest that imbalances in biometal ions and metal-amyloid interactions play crucial roles in AD pathogenesis, highlighting the importance of therapeutic chelation strategies in reducing cerebral metal burden and inhibiting A beta aggregation. Developments in multi-target ligands as potential anti-AD drug candidates show promise in addressing the limitations of current drug candidates and improving chelation-based therapeutics for AD.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Drug Delivery Challenges in Brain Disorders across the Blood-Brain Barrier: Novel Methods and Future Considerations for Improved Therapy

Aneesha Achar et al.

Summary: Various strategies have been researched to overcome the blood-brain barrier (BBB) for use in treating conditions like epilepsy, stroke, brain cancer, and traumatic brain injury. Interventions using technological and mechanical tools have been designed to enhance drug bioavailability in the treatment of severe brain disorders.

BIOMEDICINES (2021)

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Review Pharmacology & Pharmacy

Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect

Alex N. Frickenstein et al.

Summary: Mesoporous silica nanoparticles (MSNs) are being extensively researched for their theragnostic potential in treating and diagnosing various malignancies, showing significant efficacy in preclinical models. Understanding the characteristics of effective MSNs is crucial for their successful translation into clinical practice and improving clinical outcomes.

PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

A Noninvasive Gut-to-Brain Oral Drug Delivery System for Treating Brain Tumors

Yang-Bao Miao et al.

Summary: An oral prodrug delivery system has been developed to target gliomas by overcoming the intestinal epithelial barrier and the blood-brain barrier. The prodrug specifically targets intestinal M cells, crosses the barriers, and releases the active drug at the tumor site for improved therapeutic efficacy.

ADVANCED MATERIALS (2021)

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Article Materials Science, Ceramics

Biodegradability of mesoporous silica nanoparticles

Yao Hu et al.

Summary: Understanding and controlling the biodegradability of mesoporous silica nanoparticles (MSN) is crucial for enhancing their bioapplications. Research has shown that physicochemical properties such as specific surface area, morphology, and pore size play a role in MSN biodegradation. Strategies including doping with metal ions and organic species have been introduced to improve the biodegradability of MSN.

CERAMICS INTERNATIONAL (2021)

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Review Cardiac & Cardiovascular Systems

Intracranial Hemorrhage During Dual Antiplatelet Therapy JACC Review Topic of the Week

Andrew C. T. Ha et al.

Summary: Dual antiplatelet therapy (DAPT) is widely used for cardiovascular disease patients, but it may increase the risk of bleeding; patients with a history of stroke or transient ischemic attack may face a higher risk of intracranial hemorrhage when treated with DAPT; currently, there are no reversal agents that can rapidly and effectively reverse the effect of P2Y12 inhibitors.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Review Medicine, Research & Experimental

Targeting receptor-ligand chemistry for drug delivery across blood-brain barrier in brain diseases

Danielle Paige Anthony et al.

Summary: The blood-brain barrier is a complex structure composed of endothelial cells with tight junctions and regulated by various cells like astrocytes and neurons. While traditional drug delivery methods pose challenges for treating brain diseases, receptor-mediated drug delivery is considered an efficient and safe strategy that exploits the internalization of ligands by specific receptors on the blood-brain barrier.

LIFE SCIENCES (2021)

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Review Biotechnology & Applied Microbiology

Biomedical applications of metal oxide nanoparticles in aging and age-associated diseases

Somu Yadav et al.

Summary: Metal oxide nanoparticles possess unique properties such as catalyzing the neutralization of reactive oxygen species and have been increasingly utilized in diagnostics and therapeutics for age-related disorders. These nanoparticles play a critical role in reducing oxidative stress and inflammation, thus contributing to the prevention and treatment of aging-related diseases.

3 BIOTECH (2021)

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Article Materials Science, Biomaterials

Alternative Activation of Macrophages through Interleukin-13-Loaded Extra-Large-Pore Mesoporous Silica Nanoparticles Suppresses Experimental Autoimmune Encephalomyelitis

Jiyeon Park et al.

Summary: The study demonstrates the therapeutic potential of IL-13-loaded XL-MSNs for MS patients by stabilizing cytokine delivery to the central nervous system and improving symptoms.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Materials Science, Biomaterials

Lipid-Coated MCM-41 Mesoporous Silica Nanoparticles Loaded with Berberine Improved Inhibition of Acetylcholine Esterase and Amyloid Formation

Anurag Kumar Singh et al.

Summary: The study developed brain-targeted lipid-coated mesoporous silica nanoparticles containing berberine for the effective treatment of Alzheimer's disease, showing significant inhibition of amyloid fibrillation and reduction of free radicals.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Materials Science, Biomaterials

l-Dopa release from mesoporous silica nanoparticles engineered through the concept of drug-structure-directing agents for Parkinson's disease

V Morales et al.

Summary: Parkinson's disease is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons. Mesoporous silica nanoparticles were synthesized to achieve sustained release of levodopa for symptom relief.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Physical

Immunostimulatory silica nanoparticle boosts innate immunity in brain tumors

Peter A. Bielecki et al.

Summary: The study focused on using an immunostimulatory mesoporous silica nanoparticle, termed immuno-MSN, to boost the local innate immune compartment of GBM and enhance the antitumor immune response, resulting in elevated pro-inflammatory effects.

NANOSCALE HORIZONS (2021)

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Article Chemistry, Multidisciplinary

Mesoporous Silica Nanoparticles for Drug Delivery

Miguel Manzano et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Biochemistry & Molecular Biology

Quercetin in Animal Models of Alzheimer's Disease: A Systematic Review of Preclinical Studies

Xiao-Wen Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Neurosciences

Translational research on chemical nerve agents

David A. Jett et al.

NEUROBIOLOGY OF DISEASE (2020)

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Review Clinical Neurology

The global burden of neurological disorders: translating evidence into policy

Valery L. Feigin et al.

LANCET NEUROLOGY (2020)

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Article Nanoscience & Nanotechnology

A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain

Jianan Liu et al.

NATURE NANOTECHNOLOGY (2020)

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Review Chemistry, Multidisciplinary

Nanoarchitectured Structure and Surface Biofunctionality of Mesoporous Silica Nanoparticles

Ranjith Kumar Kankala et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application

Nurul Syahira Zaharudin et al.

JOURNAL OF SAUDI CHEMICAL SOCIETY (2020)

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Review Pharmacology & Pharmacy

Nose-to-brain delivery of antipsychotics using nanotechnology: a review

Madeleine S. A. Tan et al.

EXPERT OPINION ON DRUG DELIVERY (2020)

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Review Chemistry, Multidisciplinary

Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting

Mukta Agrawal et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Multidisciplinary Sciences

Non-Invasive MRI of Blood-Cerebrospinal Fluid Barrier Function

P. G. Evans et al.

NATURE COMMUNICATIONS (2020)

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Review Chemistry, Multidisciplinary

Recent Progress of Microwave-Assisted Synthesis of Silica Materials

Borja Diaz de Grenu et al.

NANOMATERIALS (2020)

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Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents

Yasmine Alyassin et al.

DRUG DISCOVERY TODAY (2020)

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Phenytoin - An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology

Jiri Patocka et al.

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Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors

Evgenii Belykh et al.

FRONTIERS IN ONCOLOGY (2020)

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Review Pharmacology & Pharmacy

Multimodal Decorations of Mesoporous Silica Nanoparticles for Improved Cancer Therapy

Sugata Barui et al.

PHARMACEUTICS (2020)

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Review Engineering, Biomedical

Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology

Rui Huang et al.

ACTA BIOMATERIALIA (2020)

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Review Chemistry, Multidisciplinary

Recent Trends in Morphology-Controlled Synthesis and Application of Mesoporous Silica Nanoparticles

Nabanita Pal et al.

NANOMATERIALS (2020)

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Article Materials Science, Biomaterials

Effect of Nanoparticle Composition, Size, Shape, and Stiffness on Penetration Across the Blood-Brain Barrier

Tyler D. Brown et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Biochemistry & Molecular Biology

Modified magnetic core-shell mesoporous silica nano-formulations with encapsulated quercetin exhibit anti-amyloid and antioxidant activity

Eleftherios Halevas et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2020)

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Article Toxicology

Cardiac Collapse Secondary to Phenytoin Toxicity in a Neonate Treated with Extracorporeal Membrane Oxygenation Support (ECMO)

Michelle Knecht et al.

JOURNAL OF MEDICAL TOXICOLOGY (2020)

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Review Pharmacology & Pharmacy

Mesoporous silica nanoparticles: synthesis, classification, drug loading, pharmacokinetics, biocompatibility, and application in drug delivery

Zhe Li et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

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Review Pharmacology & Pharmacy

Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology

Rui Pedro Moura et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

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Review Medical Laboratory Technology

Neuro-inflammation and anti-inflammatory treatment options for Alzheimer's disease

Tomris Ozben et al.

CLINICAL BIOCHEMISTRY (2019)

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Article Medicine, Research & Experimental

Targeting of Thymoquinone-loaded mesoporous silica nanoparticles to different brain areas: In vivo study

Heba M. Fahmy et al.

LIFE SCIENCES (2019)

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Review Nanoscience & Nanotechnology

Recent expansions of novel strategies towards the drug targeting into the brain

Amit Alexander et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Pharmacology & Pharmacy

Development of MCM-41 mesoporous silica nanoparticles as a platform for pramipexole delivery

Borislav Tzankov et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2019)

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Review Chemistry, Multidisciplinary

Survey of Clinical Translation of Cancer Nanomedicines-Lessons Learned from Successes and Failures

Hongliang He et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Review Chemistry, Physical

Multidisciplinary Role of Mesoporous Silica Nanoparticles in Brain Regeneration and Cancers: From Crossing the Blood-Brain Barrier to Treatment

Shruti Mendiratta et al.

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (2019)

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Article Biotechnology & Applied Microbiology

Recombinant expressing angiopep-2 fused anti-VEGF single chain Fab (scFab) could cross blood-brain barrier and target glioma

Xuemei Ji et al.

AMB EXPRESS (2019)

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Article Nanoscience & Nanotechnology

Polyethylenimine Hybrid Thin-Shell Hollow Mesoporous Silica Nanoparticles as Vaccine Self-Adjuvants for Cancer Immunotherapy

Qianqian Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Materials Science, Biomaterials

Evaluation of biomimetically synthesized mesoporous silica nanoparticles as drug carriers: Structure, wettability, degradation, biocompatibility and brain distribution

Heran Li et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Medicine, Research & Experimental

Angiopep-2-Conjugated Core-Shell Hybrid Nanovehicles for Targeted and pH-Triggered Delivery of Arsenic Trioxide into Glioma

Jiaoyang Tao et al.

MOLECULAR PHARMACEUTICS (2019)

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Review Engineering, Biomedical

Recent advancements in mesoporous silica nanoparticles towards therapeutic applications for cancer

Tingting Li et al.

ACTA BIOMATERIALIA (2019)

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Article Chemistry, Multidisciplinary

Delivery of drugs into brain tumors using multicomponent silica nanoparticles

O. Turan et al.

NANOSCALE (2019)

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Article Nanoscience & Nanotechnology

pH-Triggered Charge-Reversal Mesoporous Silica Nanoparticles Stabilized by Chitosan Oligosaccharide/Carboxymethyl Chitosan Hybrids for Effective Intracellular Delivery of Doxorubicin

Lan Cui et al.

ACS APPLIED BIO MATERIALS (2019)

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Review Clinical Neurology

Economic Evaluation of Interventions in Parkinson's Disease: A Systematic Literature Review

Nafsika Afentou et al.

MOVEMENT DISORDERS CLINICAL PRACTICE (2019)

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Article Pharmacology & Pharmacy

Treatment of Glioblastoma Using Multicomponent Silica Nanoparticles

Oguz Turan et al.

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Article Chemistry, Physical

Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage

Bong Geun Cha et al.

NANO RESEARCH (2018)

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Article Nanoscience & Nanotechnology

Design and Development of Graphene Oxide Nanoparticle/Chitosan Hybrids Showing pH-Sensitive Surface Charge-Reversible Ability for Efficient Intracellular Doxorubicin Delivery

Xubo Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Pharmacology & Pharmacy

Perspectives on the past, present, and future of cancer nanomedicine

Yu Seok Youn et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Article Clinical Neurology

Demand for neurological services in Central Eastern Europe: a 10-year national survey in Hungary

F. Oberfrank et al.

EUROPEAN JOURNAL OF NEUROLOGY (2018)

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Review Pharmacology & Pharmacy

Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region

Mukta Agrawal et al.

EXPERT OPINION ON DRUG DELIVERY (2018)

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Article Chemistry, Multidisciplinary

Enhanced oral absorption and anticancer efficacy of cabazitaxel by overcoming intestinal mucus and epithelium barriers using surface polyethylene oxide (PEO) decorated positively charged polymer-lipid hybrid nanoparticles

Tianyang Ren et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Review Chemistry, Multidisciplinary

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

Mukta Agrawal et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Chemistry, Applied

Tailoring of ordered mesoporous silica COK-12: Room temperature synthesis of mesocellular foam and multilamellar vesicles

Maria Gracia Colmenares et al.

MICROPOROUS AND MESOPOROUS MATERIALS (2018)

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Review Medicine, Research & Experimental

Current Strategies for Brain Drug Delivery

Xiaowei Dong

THERANOSTICS (2018)

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Review Biochemistry & Molecular Biology

P2X7 Receptor: A Potential Therapeutic Target for Depression?

Jan M. Deussing et al.

TRENDS IN MOLECULAR MEDICINE (2018)

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Article Multidisciplinary Sciences

Lipid-Coated Mesoporous Silica Nanoparticles for the Delivery of the ML336 Antiviral to Inhibit Encephalitic Alphavirus Infection

Annette E. LaBauve et al.

SCIENTIFIC REPORTS (2018)

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Review Psychiatry

Genetics Factors in Major Depression Disease

Maria Shadrina et al.

FRONTIERS IN PSYCHIATRY (2018)

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Review Pharmacology & Pharmacy

Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

Reema Narayan et al.

PHARMACEUTICS (2018)

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Review Neurosciences

Evaluation of intranasal delivery route of drug administration for brain targeting

Franciska Erdo et al.

BRAIN RESEARCH BULLETIN (2018)

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Article Pharmacology & Pharmacy

RGD conjugated liposome-hollow silica hybrid nanovehicles for targeted and controlled delivery of arsenic trioxide against hepatic carcinoma

Weidong Fei et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Clinical Neurology

Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

Valery L. Feigin et al.

LANCET NEUROLOGY (2017)

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Review Materials Science, Biomaterials

Preferential binding of positive nanoparticles on cell membranes is due to electrostatic interactions: A too simplistic explanation that does not take into account the nanoparticle protein corona

Valerie Forest et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Biochemistry & Molecular Biology

The role of multidrug resistance protein (MRP-1) as an active efflux transporter on blood-brain barrier (BBB) permeability

Karthik Lingineni et al.

MOLECULAR DIVERSITY (2017)

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Article Chemistry, Multidisciplinary

A polymeric temozolomide nanocomposite against orthotopic glioblastoma xenograft: tumor-specific homing directed by nestin

Suma Prabhu et al.

NANOSCALE (2017)

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Article Biochemistry & Molecular Biology

Gpr124 is essential for blood-brain barrier integrity in central nervous system disease

Junlei Chang et al.

NATURE MEDICINE (2017)

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Article Oncology

Global incidence of malignant brain and other central nervous system tumors by histology, 2003-2007

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NEURO-ONCOLOGY (2017)

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Review Chemistry, Multidisciplinary

Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer

Anna Watermann et al.

NANOMATERIALS (2017)

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Article Materials Science, Biomaterials

Overcoming Multidrug Resistance through the Synergistic Effects of Hierarchical pH-Sensitive, ROS-Generating Nanoreactors

Ranjith Kumar Kankala et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

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Article Materials Science, Biomaterials

Overcoming Multidrug Resistance through the Synergistic Effects of Hierarchical pH-Sensitive, ROS-Generating Nanoreactors

Ranjith Kumar Kankala et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

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Review Chemistry, Multidisciplinary

Form Follows Function: Nanoparticle Shape and Its Implications for Nanomedicine

Calum Kinnear et al.

CHEMICAL REVIEWS (2017)

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Article Materials Science, Ceramics

Synthesis of mesoporous silica nanoparticles by sol-gel as nanocontainer for future delivery applications

Naiara I. Vazquez et al.

BOLETIN DE LA SOCIEDAD ESPANOLA DE CERAMICA Y VIDRIO (2017)

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Article Biophysics

Nose to brain delivery in rats: Effect of surface charge of rhodamine B labeled nanocarriers on brain subregion localization

A. Bonaccorso et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Article Engineering, Biomedical

Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles

Yue Yan et al.

ACTA BIOMATERIALIA (2017)

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Article Chemistry, Medicinal

Mesoporous silica nanoparticles for efficient rivastigmine hydrogen tartrate delivery into SY5Y cells

Mahmonir Karimzadeh et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2017)

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Article Chemistry, Multidisciplinary

Enzyme-Controlled Nanodevice for Acetylcholine-Triggered Cargo Delivery Based on Janus Au-Mesoporous Silica Nanoparticles

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CHEMISTRY-A EUROPEAN JOURNAL (2017)

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Review Clinical Neurology

Crossing the Blood-Brain Barrier: Recent Advances in Drug Delivery to the Brain

Mayur M. Patel et al.

CNS DRUGS (2017)

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Article Nanoscience & Nanotechnology

Tailoring Particle Size of Mesoporous Silica Nanosystem To Antagonize Glioblastoma and Overcome Blood-Brain Barrier

Jianbin Mo et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Engineering, Biomedical

Intrinsic immunogenicity of rapidly-degradable polymers evolves during degradation

James I. Andorko et al.

ACTA BIOMATERIALIA (2016)

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Article Neurosciences

Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis

Alessandro Colasanti et al.

BIOLOGICAL PSYCHIATRY (2016)

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Review Chemistry, Inorganic & Nuclear

Recent progress in multifunctional metal chelators as potential drugs for Alzheimer's disease

M. Amelia Santos et al.

COORDINATION CHEMISTRY REVIEWS (2016)

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Article Pharmacology & Pharmacy

Phytochemical-loaded mesoporous silica nanoparticles for nose-to-brain olfactory drug delivery

Shital Lungare et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

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Review Chemistry, Multidisciplinary

Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases

Claudia Saraiva et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Chemistry, Multidisciplinary

Rapid-releasing of HI-6 via brain-targeted mesoporous silica nanoparticles for nerve agent detoxification

Jun Yang et al.

NANOSCALE (2016)

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Review Biotechnology & Applied Microbiology

From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery

William A. Banks

NATURE REVIEWS DRUG DISCOVERY (2016)

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Review Chemistry, Multidisciplinary

Advances in Peptide Functionalization on Mesoporous Silica Nanoparticles for Controlled Drug Release

Jing-Jing Hu et al.

SMALL (2016)

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Article Chemistry, Multidisciplinary

Implications for blood-brain-barrier permeability, in vitro oxidative stress and neurotoxicity potential induced by mesoporous silica nanoparticles: effects of surface modification

Ming Zhou et al.

RSC ADVANCES (2016)

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Review Microbiology

Neurological Sequelae Resulting from Encephalitic Alphavirus Infection

Shannon E. Ronca et al.

FRONTIERS IN MICROBIOLOGY (2016)

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Article Materials Science, Biomaterials

Tailored mesoporous silica nanosystem with enhanced permeability of the blood-brain barrier to antagonize glioblastoma

Yuanyuan You et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

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Article Chemistry, Multidisciplinary

Facile Synthesis of Large-Pore Bicontinuous Cubic Mesoporous Silica Nanoparticles for Intracellular Gene Delivery

Anand Kumar Meka et al.

CHEMNANOMAT (2016)

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Article Chemistry, Multidisciplinary

Reduction of Acute Inflammatory Effects of Fumed Silica Nanoparticles in the Lung by Adjusting Silanol Display through Calcination and Metal Doping

Bingbing Sun et al.

ACS NANO (2015)

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Review Pharmacology & Pharmacy

Overcoming the blood-brain tumor barrier for effective glioblastoma treatment

O. van Tellingen et al.

DRUG RESISTANCE UPDATES (2015)

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Review Biochemistry & Molecular Biology

The dynamic blood-brain barrier

James Keaney et al.

FEBS JOURNAL (2015)

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Review Oncology

Current status of intratumoral therapy for glioblastoma

Ankit I. Mehta et al.

JOURNAL OF NEURO-ONCOLOGY (2015)

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Article Chemistry, Multidisciplinary

A New Insight into Growth Mechanism and Kinetics of Mesoporous Silica Nanoparticles by in Situ Small Angle X-ray Scattering

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LANGMUIR (2015)

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Article Chemistry, Physical

Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer's disease

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NANO RESEARCH (2015)

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Review Neurosciences

Compromised autophagy and neurodegenerative diseases

Fiona M. Menzies et al.

NATURE REVIEWS NEUROSCIENCE (2015)

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Article Geriatrics & Gerontology

Comparative analysis of autophagy and tauopathy related markers in cerebral ischemia and Alzheimer's disease animal models

Javier G. Villamil-Ortiz et al.

FRONTIERS IN AGING NEUROSCIENCE (2015)

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Article Nanoscience & Nanotechnology

Facile Synthesis of Size Controllable Dendritic Mesoporous Silica Nanoparticles

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ACS APPLIED MATERIALS & INTERFACES (2014)

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Article Chemistry, Multidisciplinary

Electrically Controlled Drug Delivery from Graphene Oxide Nanocomposite Films

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ACS NANO (2014)

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Review Pharmacology & Pharmacy

Insights into direct nose to brain delivery: current status and future perspective

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DRUG DELIVERY (2014)

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Synthesis and surface modification of mesoporous silica nanoparticles and its application as carriers for sustained drug delivery

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DRUG DELIVERY (2014)

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Article Pharmacology & Pharmacy

Development of a dual nanocarrier system as a potential stratagem against amyloid- induced toxicity

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EXPERT OPINION ON DRUG DELIVERY (2014)

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Article Chemistry, Multidisciplinary

Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution

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JOURNAL OF CONTROLLED RELEASE (2014)

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Article Chemistry, Medicinal

Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus

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JOURNAL OF MEDICINAL CHEMISTRY (2014)

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Article Chemistry, Applied

Development of thioflavin-modified mesoporous silica framework for amyloid fishing

Vivekanandan Viswanathan et al.

MICROPOROUS AND MESOPOROUS MATERIALS (2014)

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Review Chemistry, Multidisciplinary

Mesoporous Silica Nanoparticle Nanocarriers: Biofunctionality and Biocompatibility

Derrick Tarn et al.

ACCOUNTS OF CHEMICAL RESEARCH (2013)

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Review Biochemistry & Molecular Biology

Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

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Review Medicine, General & Internal

Glioblastoma and Other Malignant Gliomas A Clinical Review

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

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Article Chemistry, Applied

Study of amino-functionalized mesoporous silica nanoparticles (NH2-MSN) and polyamide-6 nanocomposites co-incorporated with NH2-MSN and organo-montmorillonite

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MICROPOROUS AND MESOPOROUS MATERIALS (2013)

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Review Chemistry, Multidisciplinary

Mesoporous silica nanoparticles as antigen carriers and adjuvants for vaccine delivery

Karishma T. Mody et al.

NANOSCALE (2013)

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Article Chemistry, Multidisciplinary

Drug Release from Electric-Field-Responsive Nanoparticles

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Article Engineering, Biomedical

Effect of size on the cellular endocytosis and controlled release of mesoporous silica nanoparticles for intracellular delivery

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BIOMEDICAL MICRODEVICES (2012)

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Review Chemistry, Multidisciplinary

Bioinorganic Chemistry of Alzheimer's Disease

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CHEMICAL REVIEWS (2012)

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Article Pharmacology & Pharmacy

Penetratin-functionalized PEG-PLA nanoparticles for brain drug delivery

Huimin Xia et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

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Article Chemistry, Multidisciplinary

Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells

Wendy W. J. Unger et al.

JOURNAL OF CONTROLLED RELEASE (2012)

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Review Biotechnology & Applied Microbiology

Nanobiotechnology-based strategies for crossing the blood-brain barrier

Kewal K. Jain

NANOMEDICINE (2012)

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Article Geriatrics & Gerontology

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

Siva Sundara Kumar Durairajan et al.

NEUROBIOLOGY OF AGING (2012)

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Article Medicine, Research & Experimental

Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells

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LIFE SCIENCES (2011)

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Article Clinical Neurology

Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration

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MULTIPLE SCLEROSIS JOURNAL (2011)

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Article Materials Science, Multidisciplinary

Controlled release of phenytoin for epilepsy treatment from titania and silica based materials

Tessy Lopez et al.

MATERIALS CHEMISTRY AND PHYSICS (2011)

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Review Neurosciences

Fighting neurodegeneration with rapamycin: mechanistic insights

Jordi Bove et al.

NATURE REVIEWS NEUROSCIENCE (2011)

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Article Multidisciplinary Sciences

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

Jorge Ivan Alvarez et al.

SCIENCE (2011)

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Article Chemistry, Physical

Molecular ordering of mixed surfactants in mesoporous silicas: A solid-state NMR study

Takeshi Kobayashi et al.

SOLID STATE NUCLEAR MAGNETIC RESONANCE (2011)

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Article Chemistry, Multidisciplinary

Biofunctionalized Phospholipid-Capped Mesoporous Silica Nanoshuttles for Targeted Drug Delivery: Improved Water Suspensibility and Decreased Nonspecific Protein Binding

Li-Sheng Wang et al.

ACS NANO (2010)

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Article Chemistry, Physical

Facile Synthesis of Monodisperse Spherical MCM-48 Mesoporous Silica Nanoparticles with Controlled Particle Size

Tae-Wan Kim et al.

CHEMISTRY OF MATERIALS (2010)

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Review Neurosciences

Curcumin and Alzheimer's Disease

Tsuyoshi Hamaguchi et al.

CNS NEUROSCIENCE & THERAPEUTICS (2010)

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Review Biochemistry & Molecular Biology

Sol Gel-Derived SBA-16 Mesoporous Material

Eric M. Rivera-Munoz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2010)

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Article Chemistry, Multidisciplinary

Impacts of Mesoporous Silica Nanoparticle Size, Pore Ordering, and Pore Integrity on Hemolytic Activity

Yu-Shen Lin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

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Review Chemistry, Multidisciplinary

Effect of Surface Properties on Nanoparticle-Cell Interactions

Ayush Verma et al.

SMALL (2010)

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Article Chemistry, Physical

Synthesis of Mesoporous Silica Nanoparticles via Controlled Hydrolysis and Condensation of Silicon Alkoxide

Zhen-An Qiao et al.

CHEMISTRY OF MATERIALS (2009)

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Article Chemistry, Applied

Microwave-assisted synthesis of periodic mesoporous organosilicas with ethane and disulfide groups

Bogna E. Grabicka et al.

MICROPOROUS AND MESOPOROUS MATERIALS (2009)

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Review Chemistry, Physical

Understanding biophysicochemical interactions at the nano-bio interface

Andre E. Nel et al.

NATURE MATERIALS (2009)

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Article Chemistry, Multidisciplinary

Size Effect on Cell Uptake in Well-Suspended, Uniform Mesoporous Silica Nanoparticles

Fang Lu et al.

SMALL (2009)

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Review Chemistry, Multidisciplinary

Cytotoxicity of nanoparticles

Nastassja Lewinski et al.

SMALL (2008)

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Review Pharmacology & Pharmacy

Serotonin and depression: pathophysiological mechanism or marketing myth?

Philip J. Cowen

TRENDS IN PHARMACOLOGICAL SCIENCES (2008)

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Article Chemistry, Multidisciplinary

Mesoporous silica particles induce size dependent effects on human dendritic cells

Helen Vallhov et al.

NANO LETTERS (2007)

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Article Virology

Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection

Slobodan Paessler et al.

VIROLOGY (2007)

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Review Chemistry, Multidisciplinary

Drug targeting to the brain

William M. Pardridge

PHARMACEUTICAL RESEARCH (2007)

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Article Chemistry, Physical

Template removal and thermal stability of organically functionalized mesoporous silica nanoparticles

Rajeev Kumar et al.

CHEMISTRY OF MATERIALS (2006)

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Review Chemistry, Multidisciplinary

Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan - a review

Meera George et al.

JOURNAL OF CONTROLLED RELEASE (2006)

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Article Chemistry, Applied

Synthesis of micro-mesoporous bimodal silica nanoparticles using lyotropic mixed surfactant liquid-crystal templates

H Mori et al.

MICROPOROUS AND MESOPOROUS MATERIALS (2006)

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Article Medicine, General & Internal

Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial

RA Patchell et al.

LANCET (2005)

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Article Multidisciplinary Sciences

Mechanics of receptor-mediated endocytosis

HJ Gao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Chemistry, Multidisciplinary

Template-assisted synthesis of mesoporous magnetic nanocomposite particles

PG Wu et al.

ADVANCED FUNCTIONAL MATERIALS (2004)

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Article Geriatrics & Gerontology

Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

A Dedeoglu et al.

EXPERIMENTAL GERONTOLOGY (2004)

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Review Clinical Neurology

Combination therapy in Alzheimer's disease - A review of current evidence

B Schmitt et al.

CNS DRUGS (2004)

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Article Neurosciences

Method for measuring neurotoxicity of aggregating polypeptides with the MTT assay on differentiated neuroblastoma cells

Z Datki et al.

BRAIN RESEARCH BULLETIN (2003)

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Article Biochemistry & Molecular Biology

Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro:: implications for the prevention and therapeutics of Alzheimer's disease

K Ono et al.

JOURNAL OF NEUROCHEMISTRY (2003)

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Review Neurosciences

The metallobiology of Alzheimer's disease

AI Bush

TRENDS IN NEUROSCIENCES (2003)

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Review Biochemistry & Molecular Biology

Antioxidant treatment in Alzheimer's disease - Current state

Y Gilgun-Sherki et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2003)

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Review Genetics & Heredity

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

M Stefani et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2003)

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Article Pharmacology & Pharmacy

Regulation of blood-brain tumor barrier permeability by calcium-activated potassium channels

NS Ningaraj et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)

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Article Oncology

Improved efficacy of chemotherapy for glioblastoma by radiation-induced opening of blood-brain barrier: Clinical results

DX Qin et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2001)

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Article Neurosciences

Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice

RA Cherny et al.

NEURON (2001)

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Article Chemistry, Physical

A new property of MCM-41:: Drug delivery system

M Vallet-Regi et al.

CHEMISTRY OF MATERIALS (2001)

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Article Chemistry, Physical

Morphological control of highly ordered mesoporous silica SBA-15

DY Zhao et al.

CHEMISTRY OF MATERIALS (2000)

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