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Review
Chemistry, Multidisciplinary
Pragyan Ray et al.
Summary: Membrane technology plays a crucial role in cutting-edge innovations in the biomedical field, particularly in surface engineering for enhanced membrane longevity, efficient separation, and better throughput. Various chemical-based surface modifications and physical micro/nanotopographies are employed to improve cellular attachment, directional migration, and communication, as well as enhance diffusional transport of nutrients, gases, and waste across the membrane. These modifications not only enhance functional efficiency but also address fouling issues, biofilm formation, and infection incidences. This comprehensive review discusses different types of membranes, their fabrication and surface modifications, antifouling/antibacterial strategies, and their applications in tissue engineering, bioseparation, extracorporeal membrane devices, wound healing, and more.
Article
Nanoscience & Nanotechnology
Lanlan Wang et al.
Summary: Multifunctional hydrogel wound dressings with high adhesive, self-healing, antioxidant, and antibacterial activity were designed and fabricated for treating skin injuries in clinical care.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Yi-Ming Gao et al.
Summary: Inventions of materials with biocompatibility, bioadhesion, and easy manufacturing are urgently needed for wound healing in clinical treatment. This study reports the fabrication of a hybrid double-network polydopamine-HA (PDA-HA) hydrogel with enhanced adhesiveness compared to HA hydrogel. The PDA-HA hydrogel can be vacuum-dried to form a patch for convenient storage and distribution. When applied on wounds, the PDA-HA patch quickly rehydrates and tightly adheres to the wound, promoting wound healing and increasing healing rates.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Xifeng Liu et al.
Summary: A porous click organic-inorganic nanohybrid (PO-click-ON) cement was developed in this study through metal-free biorthogonal click chemistry and particulate leaching. The strain-promoted click reaction enabled fast and efficient crosslinking without any toxic initiator or catalyst. The resulting PO-click-ON implants showed exceptional stem cell adhesion, osteogenic differentiation, and bone formation, making it a promising platform for bone tissue engineering applications.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Yashika Tomar et al.
Summary: Nanotechnology has developed nanostructure-based drug delivery approaches, particularly nanofibers for topical delivery of therapeutics. Nanofibers, which are fabricated using various polymers, have unique structures and require a multimethod approach for studying their morphology and characterization parameters. They show potential as drug delivery carriers for various skin disorders, but large-scale production remains challenging. This review provides insights into the fabrication strategies, applications, clinical trials, and patents of nanofibers for different skin disorders, along with case studies for a better understanding.
Article
Engineering, Environmental
Faxing Zou et al.
Summary: This study developed a novel multifunctional dressing for synergistic treatment of chronic wounds, including absorption of exudate, antibacterial properties, and immune regulation. The dressing features self-negative pressure, a comfortable microenvironment, antibacterial properties, and promotion of tissue regeneration, providing a promising strategy for chronic wound management.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Jiaqi Liu et al.
Summary: Long-term recurrent infections hinder the healing of chronic diabetic wounds, posing a significant clinical challenge. In this study, Janus hydrogel dressings were developed with the ability to adjust the wound microenvironment to promote healing. These dressings had an antifouling surface to prevent bacterial adhesion and an adhesive surface for wound fixation. The incorporation of gentamicin sulfate-modified hyaluronic acid allowed intelligent release of antibiotics in response to the infected wound's acidic environment. In vivo results demonstrated that the Janus hydrogel dressings effectively inhibited inflammation, accelerated tissue regeneration, and facilitated wound healing. This multifunctional dressing holds promise for clinical application in chronic wound healing.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Nanoscience & Nanotechnology
Shannon McLoughlin et al.
Summary: Thinmembranous tissues (TMTs) are complex anatomical structures consisting of multiple stratified cell layers less than 100 μm in thickness. The fabrication of biomimetic TMTs is challenging due to their microscale architecture. Tissue engineering has emerged as a popular strategy to replace damaged TMTs, overcoming limitations of autologous and allogeneic tissue sources. This Review provides an overview of existing TMT fabrication strategies, their resolution and material capabilities, and the advantages and disadvantages of each technique.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Changgi Hong et al.
Summary: This study presents a hydrogel-nanofiber composite wound dressing composed of GelMA and poly(caprolactone) (PCL)/gelatin nanofiber, which can systematically manage the skin regeneration process with enhanced mechanical property and micropatterned surface. The composite material promotes wound healing, stimulates reepithelialization and collagen deposition. It also regulates the morphology, proliferation, and collagen synthesis of fibroblasts, as well as the expression of alpha-SMA, TGF-beta, and collagen I and III during the wound healing process both in vitro and in vivo.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Lianxu Chen et al.
Summary: With the emergence of more and more superbugs, reducing antibiotic abuse and finding nonantibiotic antimicrobial methods to counter infections are urgently needed for accelerating wound healing. This study developed an injectable drug-releasing hydrogel wound dressing by encapsulating Chinese medicinal monomer paeoniflorin in mesoporous zinc oxide nanoparticles (mZnO) and forming a hydrogel from oxidized konjac glucomannan and carboxymethyl chitosan. The dressing has demonstrated good biocompatibility and superior antibacterial properties, promoting wound healing and tissue regeneration by enhancing angiogenesis and collagen production.
ACS APPLIED BIO MATERIALS
(2023)
Review
Nanoscience & Nanotechnology
Lantian Ma et al.
Summary: Biomineralization is a process in which minerals nucleate and form specific crystal structures by regulating biomacromolecules. It occurs in bones and teeth, where collagen acts as a template for hydroxyapatite crystals. Silk proteins can also serve as templates for inorganic substances. Biomineralization enhances the properties of silk-based materials and has promising biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jingxia Han et al.
Summary: In this study, echinacoside-zinc coordination polymers (ECH-Zn) were synthesized and further wrapped in hyaluronic acid/poly(ethylenimine) (HA-PEI) nanoparticles to obtain HA-PEI-coated ECH-Zn (PPZn) nanoparticles. The PPZn nanoparticles showed better antiglycation effects in the skin and enhanced the uptake and utilization of ECH-Zn. Mechanistic studies revealed that MDM2 can interact with STAT2 to promote RAGE transcriptional activation, while PPZn can inhibit the expression and interaction of the MDM2/STAT2 complex, leading to the suppression of RAGE transcriptional activation and exerting antiglycation effects.
Article
Biochemistry & Molecular Biology
Qinghua Hou et al.
Summary: Bacterial infection, prolonged inflammation, and insufficient angiogenesis are the main challenges for effective wound repair. In this study, a stretchable, remodeling, self-healing, and antibacterial multifunctional composite hydrogel was developed for infected wound healing. The hydrogel was prepared using tannic acid (TA) and phenylboronic acid-modified gelatin (Gel-BA) through hydrogen bonding and borate ester bonds and incorporated iron-containing bioactive glasses (Fe-BGs) to achieve GTB composite hydrogels. Animal experiments showed that the GTB hydrogels remarkably accelerated infected wound healing by improving granulation tissue formation, collagen deposition, and the formation of nerves and blood vessels while decreasing inflammation. This hydrogel holds immense potential for wound dressing applications.
Article
Engineering, Biomedical
Zhipeng Zhou et al.
Summary: Diabetic foot ulcers (DFUs) are a severe and rapidly growing diabetic complication. A natural adhesive from snail mucus has been discovered to promote skin wound healing. A double-network hydrogel biomaterial composed of snail glycosaminoglycan (AFG) and methacrylated gelatin (GelMA) was developed, which exhibited strong tissue adhesion, anti-inflammatory activity, and biocompatibility. The AFG/GelMA hydrogel effectively promoted chronic wound healing.
Article
Materials Science, Multidisciplinary
Zhengchao Yuan et al.
Summary: Skin burns commonly cause edema pain, infection, slow tissue regeneration, and severe scar formation, which significantly affect wound healing. We developed multifunctional electrospun P/G-based dressings incorporated with peppermint essential oil, burn ointment, and Oregano essential oil (P/G@TBO) to promote skin regeneration. P/G@TBO showed sustained release of bioactive cues, increased cell migration, angiogenic effect, antibacterial and anti-inflammatory properties. It also facilitated fast wound healing, pain and itching relief, and scarless healing in different animal models. Harnessing the therapeutic benefits of T, B, and O in fibrous dressings holds promise for burn wound healing.
ADVANCED FIBER MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Yi Chen et al.
Summary: The researchers developed intelligent multifunctional scaffolds that can recruit VEGF and promote wound healing through angiogenesis and immunomodulation. The scaffolds showed promising results in promoting regeneration in rat wounds, with improved skin appendage neogenesis, sensory function, and collagen remodeling.
ADVANCED FIBER MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Muhammad Tayyab Noman et al.
Summary: This review focuses on the photocatalytic activity of ZnO nanostructures and their applications in various industries, with thorough characterization using analytical tools and in-depth discussion on synthesis routes and process variables affecting performance.
CRITICAL REVIEWS IN SOLID STATE AND MATERIALS SCIENCES
(2022)
Article
Engineering, Biomedical
Zhengchao Yuan et al.
Summary: This study developed VEGF-binding aligned electrospun PCL/Gel scaffolds by incorporating BP sequence and demonstrated their potential in promoting ligament regeneration. The functionalized scaffolds accumulated VEGF, enhanced tubular formation of HUVECs and wound healing in vitro, and facilitated the regeneration of matured collagen in patellar ligament in vivo.
ACTA BIOMATERIALIA
(2022)
Article
Biotechnology & Applied Microbiology
Fan Wu et al.
Summary: The synergistic effect of ZnO nanoparticles and liraglutide plays a crucial role in the treatment of infected wounds, providing simultaneous antibacterial, hemostatic, and vascularization effects.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2022)
Article
Chemistry, Applied
Xiaokun Shi et al.
Summary: A novel wound dressing with rapid hemostasis and antibacterial activity has been developed, which can achieve dual response through white light and NIR irradiation. The dressing exhibits excellent biocompatibility and has promising applications in first-aid hemostasis and wound healing.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Muhammad Umar Aslam Khan et al.
Summary: This study developed a nanosystem with enhanced antibacterial and anticancer activities and fabricated porous bioactive scaffolds. The results showed that the increase in zinc content in the scaffold led to larger pore size, increased hydrophilicity, enhanced swelling capacity, and increased degradation in phosphate-buffered saline solution. Additionally, the nanosystem exhibited exceptional antimicrobial and anticancer activities.
ACS APPLIED BIO MATERIALS
(2022)
Review
Materials Science, Multidisciplinary
Longfei Li et al.
Summary: This article presents the development of versatile strategies to construct electrospun fiber-based drug delivery systems for tissue regeneration and cancer therapy. It discusses various methods for controlling drug delivery using electrospun fibers, focusing on the design of stimuli-responsive drug delivery systems. The article summarizes recent progress in controlling drug delivery with electrospun fiber scaffolds for tissue engineering and cancer therapy, and provides insights into future development directions and challenges.
ADVANCED FIBER MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Gurvinder Kaur et al.
Summary: Skin tissue wound healing involves four stages, namely hematoma formation, inflammation, neo-tissue formation, and tissue remodeling. Advanced biomaterials play a crucial role in these stages by providing functional advantages and serving as carriers for proteins/drug molecules/growth factors. Nanomaterial-based constructs and 3D bioprinting technique are emerging as promising approaches in wound healing.
ACS APPLIED BIO MATERIALS
(2022)
Article
Engineering, Biomedical
Qiang Zhang et al.
Summary: The study successfully grafted dHAM with MA to form dHAMMA, then blended with GelMA and photocrosslinked to create GelMA-dHAMMA composite hydrogel. GelMA-dHAMMA exhibited promising properties in promoting skin wound healing and regeneration.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Zhanrong Jia et al.
Summary: Conductive silk microfibers were fabricated using a bioinspired method in this study, which were then used to make a conductive flexible silk fibroin patch for monitoring physiological signals and promoting chronic diabetic wound healing with excellent performance.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Randolph Stone et al.
Summary: This preclinical trial evaluated the use of omega-3-rich acellular fish skin graft (FSG) or fetal bovine dermis (FBD) in treating deep partial thickness burns. The results showed that FSG was more effective in stimulating granulated tissue formation than FBD, and it accelerated re-epithelialization and wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Mechanical
Rudranarayan Kandi et al.
Summary: This paper discusses the successful fabrication of customized tubular scaffolds for tracheal tissue engineering using solvent-based extrusion 3D printing. The approach was found to be flexible and accurate, with good miscibility of the PCL/PU blend and comparable mechanical properties to the human trachea. The scaffolds were biocompatible and promoted cell adhesion and proliferation in vitro, showing potential for use in tissue engineering applications.
RAPID PROTOTYPING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Yifan Shen et al.
Summary: The study developed bilayered thiolated alginate/PEG diacrylate (BSSPD) hydrogels for sequential release of different types of sEVs to promote wound healing. The results showed that phased release of sEVs can achieve scarless wound healing more quickly and effectively.
Article
Chemistry, Multidisciplinary
Lin Teng et al.
Summary: Two kinds of coordinated and covalent glycopolypeptide hydrogels with tunable tissue adhesion strength and microporous structure were fabricated. The microporous size mainly controls hemostasis, with hydrogels with larger pores achieving the fastest hemostasis and lowest blood loss. Overall, the glycopolypeptide hydrogels showed superior healing functions in animal models, with full wound closure and regeneration of dermis and epidermis with hair follicles.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Applied
Sajed Amjadi et al.
CARBOHYDRATE POLYMERS
(2020)
Article
Biochemistry & Molecular Biology
Mahjoub Jabli
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Multidisciplinary
Shenqiang Wang et al.
Review
Chemistry, Physical
Alexandra Elena Stoica et al.
Article
Engineering, Biomedical
He Zhao et al.
Article
Materials Science, Biomaterials
Muyu Yu et al.
BIOMATERIALS SCIENCE
(2020)
Article
Biochemical Research Methods
Yiqun Du et al.
IET NANOBIOTECHNOLOGY
(2019)
Review
Cell & Tissue Engineering
Alejandro A. Gorustovich et al.
TISSUE ENGINEERING PART B-REVIEWS
(2010)
