Light-responsive layer-by-layer assembled nanofibers for sequential drug release

Sequential release-based drug delivery systems, which often rely on various micro- or nanocarriers, may be the key to treating many complex diseases. In this study, we investigated a layer-by-layer assembled nanofiber platform consisting of two different drugs, i.e., camptothecin (CPT) encapsulated in nanofibers and positively charged doxorubicin (DOX) in layers. Gold nanorods with near-infrared (NIR) absorbance were inserted into the nanofibers to generate local heating via plasmon resonance upon exposure to NIR. Consequently, heat responsive polymers can shrink and swell for a controlled drug release. Linear polyethylenimine, a polycation, was used as the first layer, and poly (sodium 4-styrenesulfonate), a polyanion, was used as a simple compensation for the positively charged surface of the preceding layer. Initially, DOX was released to a lesser extent at pH 7.4, and a slightly higher release was observed at pH 6. Upon near-infrared irradiation, CPT was sequentially released in a controlled manner with further release of DOX. This study provides a flexible framework for regulated, sequential, and safe drug delivery in specific areas that can be used to treat various topical diseases.

Automated summary

Sequential release-based drug delivery systems with layer-by-layer assembled nanofiber platform were investigated in this study, which can provide a flexible framework for regulated, sequential, and safe drug delivery in specific areas.