A novel nanocomposite based on Collagen-raffinose hydrogel, embedded with carbon nitride nanosheets and ZnFe layered double hydroxides with less toxicity, antibacterial activity and enhanced mechanical properties

Article Plant Sciences

Raffinose positively regulates maize drought tolerance by reducing leaf transpiration

Ying Liu et al.

Summary: Overexpression of the ZmRAFS gene in maize increases raffinose content in leaves, reduces water loss, and enhances plant drought stress tolerance.

PLANT JOURNAL (2023)

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Article Nanoscience & Nanotechnology

Graphene Oxide-Carbamoylated Chitosan Hydrogels with Tunable Mechanical Properties for Biological Applications

Ratnika Gupta et al.

Summary: This study focuses on the formation of a nanocomposite hydrogel by adding graphene oxide (GO) nanofillers to carbamoylated chitosan (CH). The influences of chitosan molecular weight (Mw) and GO loading concentrations on hydrogel properties are studied. The results show that the physical properties of the hydrogels can be tuned by adjusting both the GO concentration and the Mw of chitosan. Rheological characterization reveals improvements in the mechanical properties of the synthesized CH-GO hydrogels with an increase in Mw and GO concentration. Human retinal pigmented epithelial-1 (RPE-1) cells exhibit good compatibility with the hydrogel scaffolds, with cell viability, adhesion, and spreading dependent on the Mw of chitosan and GO loading.

ACS APPLIED BIO MATERIALS (2023)

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Article Biochemistry & Molecular Biology

Collagen hydrogel with multiple antimicrobial mechanisms as anti-bacterial wound dressing

Xun Wang et al.

Summary: Wound infection by multidrug-resistant bacteria is a serious threat to human life. Chronic wounds, characterized by necrosis, persistent inflammation, and hypoxic tissue, pose significant challenges to anti-infection treatments. Therefore, a multifunctional hydrogel dressing has been developed to address these issues and promote wound healing. The hydrogel incorporates antimicrobial peptides, liposome-encapsulated oxygen carrier, and recombinant collagen, providing multiple antimicrobial mechanisms and improved healing for chronic wounds.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Chemistry, Multidisciplinary

Injectable Hydrogels Encapsulating Dual-Functional Au@Pt Core-Shell Nanoparticles Regulate Infarcted Microenvironments and Enhance the Therapeutic Efficacy of Stem Cells through Antioxidant and Electrical Integration

Wei Liu et al.

Summary: Significant progress has been made in the development of injectable functional biomaterials for cardiac regenerative therapy. The combination of natural alginate hydrogel and Au@Pt nanoparticles (Au@Pt/Alg hydrogel) as an injectable stem cell vector shows great potential. The Au@Pt/Alg hydrogel enhances the antioxidant and paracrine capabilities of stem cells and exhibits antioxidant, anti-inflammatory, and heart electrical integration effects in a rat myocardial infarction (MI) model. Moreover, it can effectively maintain the paracrine efficiency and pro-angiogenesis effects of stem cells in the infarcted area.

ACS NANO (2023)

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Article Engineering, Environmental

A conductive hydrogel based on nature polymer agar with self-healing ability and stretchability for flexible sensors

Zhen Nie et al.

Summary: In this work, a conductive hydrogel was constructed using dynamic crosslinking between agar and borax, along with hydrogen bonds between agar chains. The introduction of MXene nanosheets further improved the mechanical properties and ionic conductivity of the hydrogel. The assembled flexible sensor with Agar/Borax hydrogel and 0.15 wt% MXene exhibited a wide strain detection range, high sensitivity, and good stability.

CHEMICAL ENGINEERING JOURNAL (2023)

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Review Engineering, Multidisciplinary

Microfluidic Fabrication of Natural Polymer-Based Scaffolds for Tissue Engineering Applications: A Review

Elisabetta Rosellini et al.

Summary: Natural polymers have attracted significant attention as scaffold materials in tissue engineering due to their biocompatibility and biomimicry. Traditional scaffold fabrication methods have limitations in terms of structure homogeneity, pore size variability, and pore interconnectivity. Microfluidic platforms offer innovative and advanced production techniques that overcome these limitations, enabling the fabrication of scaffolds with precise geometry and uniform pore distribution and size. Additionally, microfluidics can provide a cost-effective manufacturing technique. This review discusses the microfluidic fabrication of microparticles, microfibers, and three-dimensional scaffolds based on natural polymers, as well as their applications in various tissue engineering fields.

BIOMIMETICS (2023)

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Article Chemistry, Multidisciplinary

Synthesis of hydrogels incorporating core-shell structured Fe3O4@ZIF-8 as bio-nanocomposite carriers for drug delivery

Pagasukon Mekrattanachai et al.

Summary: The Fe3O4@ZIF-8 hydrogel nanocomposite showed high biocompatibility and low cytotoxicity, making it a promising carrier for drug delivery systems. The core-shell structure of Fe3O4@ZIF-8 was confirmed through transmission electron microscopy, with a specific surface area of 821 m(2) g(-1) and a pore volume of 0.36 cm(3) g(-1). The incorporation of Fe3O4@ZIF-8 into a chitosan/pluronic F-127 hydrogel resulted in over 75% cell viability, indicating its safety for drug delivery applications.

AUSTRALIAN JOURNAL OF CHEMISTRY (2023)

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Review Food Science & Technology

Recent advances in the structure, synthesis, and applications of natural polymeric hydrogels

Khalid Gul et al.

Summary: This paper reviewed the design concepts, types, functionalities, and applications of hydrogels in food applications, with a focus on natural polymeric hydrogels. More research is needed to develop biomimetic hydrogels for different food applications.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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Review Chemistry, Multidisciplinary

Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

Yue Zhao et al.

Summary: Tissue engineering offers a promising approach for treating organ or tissue loss, with supramolecular adhesive hydrogels showing great potential due to their unique properties. This review comprehensively summarizes the design principles and applications of adhesive hydrogels, highlighting their efficacy in various tissue repair processes.

CHEMICAL REVIEWS (2022)

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Review Food Science & Technology

Advances and prospects in the food applications of pectin hydrogels

Padma Ishwarya S. et al.

Summary: Pectin hydrogel is a versatile material in the food industry, with applications in food ingredients, packaging, bioactive delivery, and health management. Its three-dimensional structure and adjustability make it an ideal choice for encapsulating biomolecules and cells, replacing fat, and inducing satiety. Coatings or composites with proteins and polysaccharides enhance its functionality.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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Article Multidisciplinary Sciences

Extension of human GCSF serum half-life by the fusion of albumin binding domain

Fatemeh Yadavar Nikravesh et al.

Summary: Fusing the albumin binding domain (ABD) to granulocyte colony stimulating factor (GCSF) can improve its pharmacokinetic properties, reduce mortality, and increase neutrophil count. Experimental results show that the ABD fusion does not significantly affect the structure of the GCSF molecule and can increase the half-life in the blood.

SCIENTIFIC REPORTS (2022)

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Article Nanoscience & Nanotechnology

Hofmeister Effect Mediated Strong PHEMA-Gelatin Hydrogel Actuator

Jian Li et al.

Summary: Hybrid hydrogels with high mechanical performance and stimuli response were achieved by utilizing the Hofmeister effect. The bicontinuous phase separation structure and the interaction between different polymer components contribute to the significant enhancement of mechanical performance. The synergy of phase separation and Hofmeister effect enables the hydrogel to contract with an enhanced modulus in high-concentration salt solutions and exhibit an ionic stimulus response and shape memory properties.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Engineering, Biomedical

Alginate-Based Hydrogels and Tubes, as Biological Macromolecule-Based Platforms for Peripheral Nerve Tissue Engineering: A Review

Walid Kamal Abdelbasset et al.

Summary: Unlike the central nervous system, the peripheral nervous system has the ability to regenerate. Autologous nerve grafting is commonly used to repair large nerve defects where direct reconnection of nerve stumps is not possible. Neural guidance channels (NGCs) and hydrogel-based drug delivery systems have been developed to address the challenges of autologous nerve grafting. Alginate, a naturally occurring polysaccharide, has shown promising results in the repair of peripheral nervous system injuries.

ANNALS OF BIOMEDICAL ENGINEERING (2022)

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Article Biochemistry & Molecular Biology

Biocompatible Synthetic Polymers for Tissue Engineering Purposes

Zoi Terzopoulou et al.

Summary: Synthetic polymers have been an integral part of modern society since the early 1960s, with applications in packaging, construction, textiles, electronics, and the field of medicine. Research on polymeric materials, stem cells, and three-dimensional printing has contributed to the rapid progress of tissue engineering and regenerative medicine. This perspective discusses the role of synthetic polymers in tissue engineering, their design and properties, and outlines recent achievements in the field.

BIOMACROMOLECULES (2022)

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Article Chemistry, Physical

Separation of halloysite/kaolinite mixtures in water controlled by sucrose addition: The influence of the attractive forces on the sedimentation behavior

Martina Maria Calvino et al.

Summary: This study presents a simple strategy for separating halloysite/kaolinite mixtures in sucrose aqueous solution. Experimental results showed that sucrose concentration influences the dynamic behavior of halloysite nanotubes, while the addition of sucrose has minimal effect on the zeta potential of the nanoparticles. By analyzing sedimentation kinetics and behaviors of kaolinite and halloysite dispersions, it was confirmed that optimal separation may be achieved in 10 wt% sucrose solution. The efficiency of the separation protocol was determined through thermogravimetric experiments on the separated material and composites with variable composition.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2022)

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Article Biochemistry & Molecular Biology

Optimization of chitosan/tannic acid@ ZnFe layered double hydroxide bionanocomposite film for removal of reactive blue 4 using a response surface methodology

Shadpour Mallakpour et al.

Summary: In this study, bio-nanocomposite films containing chitosan, tannic acid, and layered double hydroxides were fabricated and applied for the removal of reactive blue 4. The effect of operating parameters on dye removal was investigated using a response surface methodology, and an optimized condition was obtained. The results also showed that the film had good adsorption performance and thermodynamic properties.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Sepabeads EC-EP immobilized α-galactosidase: Immobilization, characterization and application in the degradation of raffinose-type oligosaccharides

Evran Bicak Celem et al.

Summary: The immobilized alpha-galactosidase can effectively hydrolyze RFOs in soymilk, thus improving its nutritional value.

PROCESS BIOCHEMISTRY (2022)

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Article Engineering, Chemical

Fabrication of PSf nanocomposite membranes incorporated with ZnFe layered double hydroxide for separation and antifouling aspects

Cigdem Balcik et al.

Summary: This study investigated the effects of blending ZnFe layered double hydroxide on the filtration, antifouling, and antibacterial performances of Polysulfone nanocomposite membranes. The results showed that the incorporation of ZnFe LDH led to improved hydrophilicity, porosity, water flux, rejection ratios, and antifouling properties, as well as enhanced antibacterial properties compared to pristine PSf membranes.

SEPARATION AND PURIFICATION TECHNOLOGY (2022)

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Review Engineering, Biomedical

Hydrogel Combined with Phototherapy in Wound Healing

Yinglin Xu et al.

Summary: Combining hydrogels with phototherapy shows great potential for wound healing, overcoming the shortcomings of traditional treatment methods. Phototherapy can effectively treat bacterial infections, while hydrogels provide a moist environment for wound healing.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Chemistry, Applied

Co-delivery of hydrophobic astaxanthin and hydrophilic phycocyanin by a pH-sensitive water-in-oil-in-water double emulsion-filled gellan gum hydrogel

Hongjin Yu et al.

Summary: In this study, a pH-sensitive double emulsion-filled gellan gum hydrogel was prepared for intestinal targeted delivery of food bioactive ingredients. The double emulsions remained stable during storage and maintained their microstructure under acidic conditions. The gellan gum hydrogel showed high encapsulation efficiency and intestinal targeted release ability.

FOOD HYDROCOLLOIDS (2022)

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Review Chemistry, Physical

Advances in LDH coatings on Mg alloys for biomedical applications: A corrosion perspective

Jesslyn K. E. Tan et al.

Summary: This review discusses the potential of layered double hydroxide (LDH) films as protective coatings for magnesium (Mg) alloys in implant applications. LDH films are considered to delay corrosion of Mg alloys due to their tunable crystal structure and corrosion inhibiting properties. The biodegradability and biocompatibility of LDH films make them a promising coating for next generation implant applications.

APPLIED CLAY SCIENCE (2021)

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Article Nanoscience & Nanotechnology

Utilization of residual zinc-iron-layered double hydroxide after methyl orange management as a new sorbent for wastewater treatment

Doaa Moustafa et al.

Summary: In this study, Zn-Fe LDH with nitrate as the interlayer anions was prepared via the co-precipitation technique and tested for the remediation of wastewater containing anionic methyl orange. The results showed that Zn-Fe LDH had a high adsorption capacity for methyl orange, with pH 7 being the optimum value for adsorption. The adsorption kinetics followed pseudo-first and -second order models, while the equilibrium data fit Langmuir model. Additionally, the recycled adsorbent was effective in managing another dye, methylene blue.

APPLIED NANOSCIENCE (2021)

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Article Chemistry, Physical