期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 89, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jddst.2023.105038
关键词
Collagen; Raffinose; Layered double hydroxides; Biocompatible; Antibacterial
Coll-Raff hydrogel/g-C3N4/ZnFe LDH nanobiocomposite was prepared using collagen and raffinose as natural polymers, and g-C3N4 and MnFe LDH were added to enhance its mechanical properties and antibacterial activity. Characteristic investigations and biological assessments showed that this nanobiocomposite has high cell viability and antibacterial activity against P. aeruginosa, making it a potential candidate for wound healing and tissue engineering applications.
Recently, natural-based hydrogels with three dimensional networks have been investigated significantly due to their unique properties such as swelling capacity, biocompatibility, biodegradability, tunable mechanical properties and chemical stability. Other than natural polymers, natural macromolecules can be also used for preparation of natural hydrogels. In this study, two of the most studied natural polymers and macromolecules, collagen and raffinose were used to prepare collagen-raffinose hydrogel. In following, in order to enhance the hydrogels mechanical properties and adding antibacterial properties, g-C3N4 and MnFe LDH were added to the structure and the Coll-Raff hydrogel/g-C3N4/ZnFe LDH nanobiocomposite was prepared. This nanobiocomposite was subjected to TGA, EDX, FE-SEM, FT-IR and XRD characteristic investigations and biological assessments of MTT and anti-biofilm activity assays. Mechanical properties of the Coll-Raff hydrogel/g-C3N4/ZnFe LDH was also studied. 95.61%, 91.25% and 86.21% cell viability were obtained within 24h, 48h and 72h, respectively. Also, a viscoelastic material was observed with antibacterial activity against P. aeruginosa, showing this nano-biocomposite capability as a good candidate for wound healing and tissue engineering applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据