期刊
JOURNAL OF DERMATOLOGICAL TREATMENT
卷 34, 期 1, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2023.2248311
关键词
jRCT-2080224657; >; Acetylcysteine (AC) gel; distal narrowed nail width; overcurvature-correcting device; pincer nail
类别
The efficacy and safety of treatment with acetylcysteine (AC) gel added to an overcurvature-correcting device for hallux pincer nail were evaluated in this study. The optimal AC concentration was found to be 10%. The addition of AC gel to the device showed earlier and sustained reductions in transverse curvature compared to using the device alone.
Background While pincer nails may be treated using overcurvature-correcting devices, it takes several months to achieve successful outcomes. Nail-softening drugs may reduce the treatment duration required. Objective To evaluate the efficacy and safety of treatment with acetylcysteine (AC) gel added to an overcurvature-correcting device, and define the optimal AC concentration. Methods In this investigator-blinded study, 70 patients with hallux pincer nail were fitted with an overcurvature-correcting device for 7 days and were randomly assigned to receive a single 24-h administration of a gel containing 10%, 20% or 30% AC or vehicle. Nail improvement was objectively evaluated by calculating the distal narrowed nail width (dNNW) ratio. Results All three AC concentrations plus device showed earlier sustained improvement of pincer nails versus vehicle plus device. There was no observable correlation between AC concentration and effectiveness. No clinically problematic adverse events were observed at any AC concentration, and we recommended AC gel at a concentration of 10%. Conclusions By adding AC gel application to an overcurvature-correcting device, early and sustained reductions in transverse curvature were produced compared with using a device alone (vehicle control). The dNNW ratio used in this study was an appropriate objective index for evaluating therapeutic effects.
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