Navigating chimeric antigen receptor-engineered natural killer cells as drug carriers via three-dimensional mapping of the tumor microenvironment

Article Cell Biology

CAR NK-92 cells targeting DLL3 kill effectively small cell lung cancer cells in vitro and in vivo

Manting Liu et al.

Summary: In this study, DLL3-specific NK-92 cells were developed and it was found that they have potential therapeutic effects on SCLC.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

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Article Multidisciplinary Sciences

In vivo imaging of nanoparticle-labeled CAR T cells

Louise Kiru et al.

Summary: The study introduces a new approach to label CAR T cells with iron oxide nanoparticles, enabling noninvasive detection of the CAR T cells in solid tumors. The results show that labeled CAR T cells could locate to osteosarcomas and off-target sites, while unlabeled cells were not visible. This study provides a new method for monitoring the location of CAR T cells in solid tumors.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Review Cell Biology

2022 update on the scientific premise and clinical trials for IL-15 agonists as cancer immunotherapy

Yingjun Peng et al.

Summary: This review outlines the potential and applications of IL-15 in cancer immunotherapy, discussing its role in regulating immune cells and providing prospects for future therapeutic designs.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

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Article Biophysics

Visualization of natural killer cell-mediated killing of cancer cells at single-cell resolution in live zebrafish

Hongmei Yang et al.

Summary: Tumor immunotherapy, especially NK cell-based therapy, has gained attention due to its effectiveness with fewer side effects. This study establishes a 3D coculture model using fluorescence resonance energy transfer (FRET) and zebrafish, allowing real-time visualization of the interaction and killing process of NK cells against cancer cells at single-cell resolution. The findings demonstrate the potential of NK cell therapy and provide a valuable in vivo tool for its development and evaluation.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Multidisciplinary Sciences

Remodelling of tumour microenvironment by microwave ablation potentiates immunotherapy of AXL-specific CAR T cells against non-small cell lung cancer

Bihui Cao et al.

Summary: The complex immunosuppressive tumor microenvironment and lack of tumor-specific targets hinder the application of CAR T cell therapy in solid tumors. AXL, highly expressed in NSCLC but not in normal tissues, might be a target for CAR T cell therapy. Combining microwave ablation and AXL-CAR T cells shows superior antitumor efficacy.

NATURE COMMUNICATIONS (2022)

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Review Oncology

Current Progress of CAR-NK Therapy in Cancer Treatment

Zhaojun Pang et al.

Summary: CAR-NK therapy, as a promising cancer treatment, attracts attention due to its lack of adverse effects observed in CAR-T therapies and its effectiveness in killing cancer cells. However, CAR-NK therapy faces challenges such as difficulties in transduction and expansion of NK cells, as well as time, cost, and potential biohazard issues.

CANCERS (2022)

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Review Biochemistry & Molecular Biology

Recent advances in organotypic tissue slice cultures for anticancer drug development

Lin He et al.

Summary: Organotypic tissue slice culture has numerous advantages in anticancer drug development, including the preservation of cell repertoire, quick assessment of therapeutic efficacy, and the ability to select personalized treatment regimens. It is expected to become a potent platform for individualized drug screening.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Review Oncology

NK cell-based cancer immunotherapy: from basic biology to clinical development

Sizhe Liu et al.

Summary: NK cells, as a specialized immune effector cell type, play a critical role in immune activation against abnormal cells. Unlike T cell activation, NK cell activation is governed by interactions between NK receptors and target cells, leading to significant attention in cancer immunotherapy. Many efforts are focused on developing and engineering NK cell-based cancer immunotherapy.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Review Multidisciplinary Sciences

Engineering approaches for studying immune-tumor cell interactions and immunotherapy

Sarah E. Shelton et al.

Summary: Recent research using advanced 3D in vitro models and engineering approaches has enhanced our understanding of the role of immune cells in the tumor microenvironment (TME). Reconstruction of the TME with engineered 3D models allows detailed observation of cell interactions and identification of new biological targets and personalized medicine strategies.

ISCIENCE (2021)

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Article Oncology

Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes

Jie Liu et al.

Summary: The study demonstrates that using B7-H3 CAR-T cells and B7-H3/CD16 BiKE can effectively inhibit NSCLC tumor growth, and direct CD16 signaling can significantly increase NK cell activity and target cell death. Additionally, inhibition of B7-H3 may alter tumor glucose metabolism via the reactive oxygen species-mediated pathway.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Oncology

Imaging CAR T-cell kinetics in solid tumors: Translational implications

Matthew S. Skovgard et al.

Summary: Success in solid tumor chimeric antigen receptor (CAR) T-cell therapy requires overcoming several barriers, including lung sequestration, inefficient accumulation within the tumor, and target-antigen heterogeneity. Understanding CAR T-cell kinetics can assist in the interpretation of therapy response and limitations and thereby facilitate developing successful strategies to treat solid tumors. The study suggests the need to develop a T-cell reporter gene for repeated imaging to address the limitations identified.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Article Medicine, Research & Experimental

Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform

Fuqiang Xing et al.

Summary: The study developed a 3D tumor slice culture platform for predicting drug efficacy, screening high-efficacy candidates, preserving immune components of original tumors, and accelerating drug discovery and efficacy evaluation for cancer treatment.

THERANOSTICS (2021)

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Article Biochemistry & Molecular Biology

Development of mesothelin-specific CAR NK-92 cells for the treatment of gastric cancer

Bihui Cao et al.

Summary: The study demonstrated that MSLN-CAR NK cells exhibit strong antitumor activity and can effectively kill MSLN-positive gastric cancer cells, showing promising therapeutic potential for gastric cancer treatment. Moreover, MSLN-CAR NK cells also significantly prolonged the survival of tumor-bearing mice in both subcutaneous and intraperitoneal tumor models, indicating their potent antitumor effects in vivo. Additionally, the observations of potent antitumor effects and significant NK cell infiltration in patient-derived xenografts treated with MSLN-CAR NK cells further supported the therapeutic efficacy of MSLN-CAR NK cells for gastric cancer.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Letter Biochemistry & Molecular Biology

Administration of B7-H3 targeted chimeric antigen receptor-T cells induce regression of glioblastoma

Xin Tang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biotechnology & Applied Microbiology

Imaging CAR T Cell Trafficking with eDHFR as a PET Reporter Gene

Mark A. Sellmyer et al.

MOLECULAR THERAPY (2020)

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Article Medicine, General & Internal

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

Enli Liu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Pharmacology & Pharmacy

Targeting B7-H3 Immune Checkpoint With Chimeric Antigen Receptor-Engineered Natural Killer Cells Exhibits Potent Cytotoxicity Against Non-Small Cell Lung Cancer

Shuo Yang et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Cell Biology

Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors

Emmanuel Donnadieu et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

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Review Medicine, General & Internal

CAR-NK cells: A promising cellular immunotherapy for cancer

Guozhu Xie et al.

EBIOMEDICINE (2020)

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Editorial Material Oncology

The ongoing trends of patient-derived xenograft models in oncology

Jianyong Zhuo et al.

CANCER COMMUNICATIONS (2020)

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Article Oncology

Emergence of spatio-temporal variations in chemotherapeutic drug efficacy: in-vitro and in-Silico 3D tumour spheroid studies

M. V. Sheraton et al.

BMC CANCER (2020)

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Review Chemistry, Multidisciplinary

Immune cells as tumor drug delivery vehicles

Francis Combes et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Biochemistry & Molecular Biology

3D model for CAR-mediated cytotoxicity using patient-derived colorectal cancer organoids

Theresa E. Schnalzger et al.

EMBO JOURNAL (2019)

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Review Oncology

The role of mouse tumour models in the discovery and development of anticancer drugs

Christopher R. Ireson et al.

BRITISH JOURNAL OF CANCER (2019)

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Article Multidisciplinary Sciences

Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice

Matthias Mulazzani et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Biotechnology & Applied Microbiology

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

Ana S. Nunes et al.

BIOTECHNOLOGY AND BIOENGINEERING (2019)

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Article Oncology

Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment

Steve Seung-Young Lee et al.

MOLECULAR CANCER THERAPEUTICS (2019)

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Review Hematology

Novel chimeric antigen receptor T cells based on T-cell receptor-like antibodies

Qi Zhao

BLOOD SCIENCE (2019)

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Article Chemistry, Multidisciplinary

Targeting immune checkpoint B7-H3 antibody-chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy

Lipeng Zhu et al.

CHEMICAL COMMUNICATIONS (2019)

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Review Immunology

Building Potent Chimeric Antigen Receptor T Cells With CRISPR Genome Editing

Jie Liu et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Loading of Indocyanine Green within Polydopamine-Coated Laponite Nanodisks for Targeted Cancer Photothermal and Photodynamic Therapy

Fanli Xu et al.

NANOMATERIALS (2018)

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Article Chemistry, Multidisciplinary

Photosensitization Priming of Tumor Microenvironments Improves Delivery of Nanotherapeutics via Neutrophil Infiltration

Dafeng Chu et al.

ADVANCED MATERIALS (2017)

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Article Medicine, Research & Experimental

Longitudinal PET imaging demonstrates biphasic CAR T cell responses in survivors

Yogindra Vedvyas et al.

JCI INSIGHT (2016)

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Article Chemistry, Multidisciplinary

Elucidating the Fundamental Mechanisms of Cell Death Triggered by Photothermal Therapy

Jilian R. Melamed et al.

ACS NANO (2015)

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Article Biochemistry & Molecular Biology

Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3

Mahiuddin Ahmed et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Article Oncology

Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential

Q. Zhao et al.

LEUKEMIA (2015)

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Review Surgery

Recent advances in near-infrared fluorescence-guided imaging surgery using indocyanine green

Tsutomu Namikawa et al.

SURGERY TODAY (2015)

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Article Medicine, General & Internal

Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia

Stephan A. Grupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Biochemical Research Methods

Imaging morphodynamics of human blood cells in vivo with video-rate third harmonic generation microscopy

Chien-Kuo Chen et al.

BIOMEDICAL OPTICS EXPRESS (2012)

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Article Multidisciplinary Sciences

Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy

MJ Miller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Navigating chimeric antigen receptor-engineered natural killer cells as drug carriers via three-dimensional mapping of the tumor microenvironment

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