☆ 4.8 Article

Spray dried lipid nanoparticle formulations enable intratracheal delivery of mRNA

JOURNAL OF CONTROLLED RELEASE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Multidisciplinary

Spray drying siRNA-lipid nanoparticles for dry powder pulmonary delivery

Christoph M. Zimmermann et al.

Summary: This study verifies the successful spray drying procedure of LNP-siRNA systems maintaining their integrity and mediating strong gene silencing efficiency on mRNA and protein levels both in vitro and ex vivo. The successful spray drying procedure of LNP-siRNA formulations in 5% lactose solution creates a novel siRNA-based therapy option to target respiratory diseases such as lung cancer, asthma, COPD, cystic fibrosis and viral infections.

JOURNAL OF CONTROLLED RELEASE (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Self-assembled mRNA vaccines

Jeonghwan Kim et al.

Summary: mRNA vaccines, emerging as front-runners in the COVID-19 vaccine race, utilize advancements in RNA technology, vaccinology, and nanotechnology to design self-assembled nanoparticles for vaccine delivery, showing tremendous promise and readiness for clinical use.

ADVANCED DRUG DELIVERY REVIEWS (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Leucine enhances the dispersibility of trehalose-containing spray-dried powders on exposure to a high-humidity environment

Zheng Wang et al.

Summary: This study found that a formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after exposure to high humidity and temperature, demonstrating superior protection against moisture. Further investigations on trehalose/leucine combinations with different compositions revealed that higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

Linde Schoenmaker et al.

Summary: The current mRNA-lipid nanoparticle COVID-19 vaccines require storage at low temperatures due to instability. Improving mRNA nucleotide composition, understanding the impact of mRNA environment within LNPs, and exploring drying techniques can enhance vaccine stability.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

The dawn of mRNA vaccines: The COVID-19 case

Rein Verbeke et al.

Summary: In less than a year since the COVID-19 pandemic outbreak, mRNA vaccines have made significant progress, with two receiving emergency use authorization and one moving to phase 3 clinical testing. These mRNA vaccines represent a new class of vaccine products, encoding the SARS-CoV-2 Spike glycoprotein to deliver mRNA to cells. The review provides a detailed overview of the composition, clinical performance, and design considerations of the most advanced mRNA vaccines, highlighting new insights and areas for future research and optimization.

JOURNAL OF CONTROLLED RELEASE (2021)

添加到收藏夹

Review Engineering, Chemical

Designing enhanced spray dried particles for inhalation: A review of the impact of excipients and processing parameters on particle properties

Nasser Alhajj et al.

Summary: Spray drying is a beneficial manufacturing technique used to produce dry powder, especially for inhalable powder formulations. The complexity of drying kinetics and particle formation process, along with the specificity of physicochemical characteristics of inhalable particles, make this a fascinating research area.

POWDER TECHNOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Trileucine as a dispersibility enhancer of spray-dried inhalable microparticles

Mani Ordoubadi et al.

Summary: The study investigated the formation of trileucine-containing spray-dried microparticles for pulmonary delivery. It was found that adding a small amount of trileucine could significantly lower particle densities, and particle morphology and surface composition varied with different trileucine concentrations.

JOURNAL OF CONTROLLED RELEASE (2021)

添加到收藏夹

Article Engineering, Biomedical

Trileucine and Pullulan Improve Anti-Campylobacter Bacteriophage Stability in Engineered Spray-Dried Microparticles

Nicholas B. Carrigy et al.

ANNALS OF BIOMEDICAL ENGINEERING (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo

Khalid A. Hajj et al.

NANO LETTERS (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Piotr S. Kowalski et al.

MOLECULAR THERAPY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

Kimberly J. Hassett et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

Yingshan Qiu et al.

JOURNAL OF CONTROLLED RELEASE (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH

Khalid A. Hajj et al.

SMALL (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc et al.

NATURE NANOTECHNOLOGY (2019)

添加到收藏夹

Article Respiratory System

Critical Parameters for Particle-Based Pulmonary Delivery of Chemotherapeutics

Ali Dabbagh et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

Staci Sabnis et al.

MOLECULAR THERAPY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA

Rebecca L. Ball et al.

NANO LETTERS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

Marianna Yanez Arteta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

添加到收藏夹

Review Biotechnology & Applied Microbiology

An RNA toolbox for cancer immunotherapy

Fernando Pastor et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Determination of the Main Phase Transition Temperature of Phospholipids by Nanoplasmonic Sensing

Wen Chen et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Review Genetics & Heredity

Advances in the delivery of RNA therapeutics: from concept to clinical reality

James C. Kaczmarek et al.

GENOME MEDICINE (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery

Xinwei Cheng et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

添加到收藏夹

Review Chemistry, Physical

Control of particle morphology in the spray drying of colloidal suspensions

E. Lintingre et al.

SOFT MATTER (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Norbert Pardi et al.

JOURNAL OF CONTROLLED RELEASE (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

Kevin J. Kauffman et al.

NANO LETTERS (2015)

添加到收藏夹

Review Chemistry, Medicinal

Next Generation Drying Technologies for Pharmaceutical Applications

Robert H. Walters et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

添加到收藏夹

Review Genetics & Heredity

Non-viral vectors for gene-based therapy

Hao Yin et al.

NATURE REVIEWS GENETICS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

Kathryn A. Whitehead et al.

NATURE COMMUNICATIONS (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

Muthusamy Jayaraman et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

添加到收藏夹

Article Environmental Sciences

Aggravating Impact of Nanoparticles on Immune-Mediated Pulmonary Inflammation

Ken-Ichiro Inoue et al.

THESCIENTIFICWORLDJOURNAL (2011)

添加到收藏夹

Article Chemistry, Multidisciplinary

Optimized pulmonary gene transfection in mice by spray-freeze dried powder inhalation

Kohta Mohri et al.

JOURNAL OF CONTROLLED RELEASE (2010)

添加到收藏夹

Review Immunology

Immunity to Respiratory Viruses

Jacob E. Kohlmeier et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

添加到收藏夹

Review Chemistry, Multidisciplinary

Pharmaceutical particle engineering via spray drying

Reinhard Vehring

PHARMACEUTICAL RESEARCH (2008)

添加到收藏夹

Article Pharmacology & Pharmacy

Dry powder aerosol delivery of large hollow nanoparticulate aggregates as prospective carriers of nanoparticulate drugs: Effects of phospholipids

Kunn Hadinoto et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2007)

添加到收藏夹

Article Immunology

Suppression of RNA recognition by Toll-like receptors:: The impact of nucleoside modification and the evolutionary origin of RNA

K Karikó et al.

IMMUNITY (2005)

添加到收藏夹

Article Multidisciplinary Sciences

Trojan particles: Large porous carriers of nanoparticles for drug delivery

N Tsapis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.